Insl6 insulin-like 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Insl6provided by MGI
Official Full Name: insulin-like 6provided by MGI
Primary source: MGI:MGI:1351595
See related: Ensembl:ENSMUSG00000050957 AllianceGenome:MGI:1351595
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: RIF1
Summary: Predicted to enable hormone activity. Acts upstream of or within several processes, including flagellated sperm motility; male gonad development; and spermatid development. Predicted to be located in extracellular region. Is expressed in several structures, including colon; gonad; heart; hemolymphoid system gland; and liver. Orthologous to human INSL6 (insulin like 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in testis adult (RPKM 98.8), large intestine adult (RPKM 7.8) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 19 C1; 19 23.82 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (29298754..29302718, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (29321354..29325318, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TNF-Polarized Macrophages Produce Insulin-like 6 Peptide to Stimulate Bone Formation in Rheumatoid Arthritis in Mice.
Title: TNF-Polarized Macrophages Produce Insulin-like 6 Peptide to Stimulate Bone Formation in Rheumatoid Arthritis in Mice.
Endogenous Insl6 protein inhibits cardiac systolic dysfunction and cardiac fibrosis in angiotensin II- and isoproterenol-induced cardiac stress models.
Title: Relaxin Family Member Insulin-Like Peptide 6 Ameliorates Cardiac Fibrosis and Prevents Cardiac Remodeling in Murine Heart Failure Models.
Data indicate that Insl6 is an injury-regulated myokine that functions as a myogenic regenerative factor.
Title: Insulin-like 6 is induced by muscle injury and functions as a regenerative factor.
results suggest that INSL6 modulates two different processes related to fertility, spermatogenesis, and sperm motility.
Title: Inactivation of insulin-like factor 6 disrupts the progression of spermatogenesis at late meiotic prophase.
Insl6 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia.
Title: Tissue expression patterns identify mouse cilia genes.
The presence of immunoreactive INSL6 in discrete populations of hypothalamic and brainstem neurons and in Leydig cells of the testis suggests a diverse biological function of this novel peptide.
Title: Insulin-like 6 immunoreactivity in the mouse brain and testis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

General gene information

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Markers

RH135780 (e-PCR)
- UniSTS:158735

NoName (e-PCR)
- UniSTS:237917

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables hormone activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of ectopic germ cell programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within fertilization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within flagellated sperm motility	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within male gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of developmental process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of reproductive process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within spermatid development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: insulin-like peptide INSL6

Names: insulin-like peptide 6; relaxin/insulin-like factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013754.1 → NP_038782.1 insulin-like peptide INSL6 precursor

See identical proteins and their annotated locations for NP_038782.1

Status: PROVISIONAL

Source sequence(s)

AF143807

Consensus CDS

CCDS29732.1

UniProtKB/Swiss-Prot

Q9QY05

UniProtKB/TrEMBL

Q545M1

Related

ENSMUSP00000054488.4, ENSMUST00000052380.5

Conserved Domains (2) summary

cd00101
Location:32 → 52

IlGF_like; Insulin/insulin-like growth factor/relaxin family; insulin family of proteins. Members include a number of active peptides which are evolutionary related including insulin, relaxin, prorelaxin, insulin-like growth factors I and II, mammalian Leydig ...

cd04365
Location:148 → 185

IlGF_relaxin_like; IlGF_like family, relaxin_like subgroup, specific to vertebrates. Members include a number of active peptides including (pro)relaxin, mammalian Leydig cell-specific insulin-like peptide (gene INSL3), early placenta insulin-like peptide (ELIP; gene INSL4), ...