U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Pald1 phosphatase domain containing, paladin 1 [ Mus musculus (house mouse) ]

Gene ID: 27355, updated on 21-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Pald1provided by MGI
Official Full Name
phosphatase domain containing, paladin 1provided by MGI
Primary source
MGI:MGI:1351623
See related
Ensembl:ENSMUSG00000020092 AllianceGenome:MGI:1351623
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pald; MMPAL; mKIAA1274
Summary
Predicted to enable protein tyrosine phosphatase activity. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in several structures, including cardiovascular system; central nervous system; jaw; lung; and urinary system. Orthologous to human PALD1 (phosphatase domain containing paladin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 28.7), ovary adult (RPKM 19.2) and 26 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
10 B4; 10 32.19 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (61155435..61219325, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (61319656..61383546, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L27A, pseudogene 1 Neighboring gene perforin 1 (pore forming protein) Neighboring gene STARR-seq mESC enhancer starr_26836 Neighboring gene STARR-seq mESC enhancer starr_26839 Neighboring gene STARR-seq mESC enhancer starr_26844 Neighboring gene nodal growth differentiation factor Neighboring gene eukaryotic translation initiation factor 4E binding protein 2

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Paladin is a phosphoinositide phosphatase regulating endosomal VEGFR2 signalling and angiogenesis. Nitzsche A, et al. EMBO Rep, 2021 Feb 3. PMID 33369848, Free PMC Article
  2. Negative regulators of insulin signaling revealed in a genome-wide functional screen. Huang SM, et al. PLoS One, 2009 Sep 3. PMID 19727444, Free PMC Article
  3. Female mice lacking Pald1 exhibit endothelial cell apoptosis and emphysema. Egaña I, et al. Sci Rep, 2017 Nov 13. PMID 29133847, Free PMC Article
  4. Paladin (X99384) is expressed in the vasculature and shifts from endothelial to vascular smooth muscle cells during mouse development. Wallgard E, et al. Dev Dyn, 2012 Apr. PMID 22354871
  5. Integrated microarray and ChIP analysis identifies multiple Foxa2 dependent target genes in the notochord. Tamplin OJ, et al. Dev Biol, 2011 Dec 15. PMID 22008794

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Paladin is a phosphoinositide phosphatase regulating endosomal VEGFR2 signalling and angiogenesis.
    Title: Paladin is a phosphoinositide phosphatase regulating endosomal VEGFR2 signalling and angiogenesis.
  2. Study describes the phenotype of Pald1 +/- and Pald1 -/- mice and characterize lung defects linking Pald1 to sex-specific endothelial cell apoptosis, development of emphysema and chronic obstructive pulmonary disease-like changes in females.
    Title: Female mice lacking Pald1 exhibit endothelial cell apoptosis and emphysema.
  3. Paladin, a novel putative phosphatase, displays a dynamic expression pattern in the vasculature; During embryonic stages it is broadly expressed in endothelial cells, while in the adult it is selectively expressed in arterial smooth muscle cells
    Title: Paladin (X99384) is expressed in the vasculature and shifts from endothelial to vascular smooth muscle cells during mouse development.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC169319

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
paladin

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001372378.1 → NP_001359307.1  paladin isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC122197, AC151895
    UniProtKB/TrEMBL
    B7ZMW4, B7ZMW5
    Conserved Domains (2) summary
    cd17659
    Location:94 → 386
    PTP_paladin_1; protein tyrosine phosphatase-like domain of paladin, repeat 1
    cd17660
    Location:480 → 737
    PTP_paladin_2; protein tyrosine phosphatase-like domain of paladin, repeat 2

  2. NM_013753.3 → NP_038781.2  paladin isoform 1

    See identical proteins and their annotated locations for NP_038781.2

    Status: VALIDATED

    Source sequence(s)
    AC122197, AC151895
    Consensus CDS
    CCDS23877.1
    UniProtKB/TrEMBL
    A0A0R4J007, B7ZMW5
    Related
    ENSMUSP00000020289.9, ENSMUST00000020289.10
    Conserved Domains (2) summary
    cd17659
    Location:94 → 385
    PTP_paladin_1; protein tyrosine phosphatase-like domain of paladin, repeat 1
    cd17660
    Location:479 → 736
    PTP_paladin_2; protein tyrosine phosphatase-like domain of paladin, repeat 2

RNA

  1. NR_190530.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC122197, AC151895

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    61155435..61219325 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513706.5 → XP_006513769.1  paladin isoform X1

    See identical proteins and their annotated locations for XP_006513769.1

    UniProtKB/TrEMBL
    B7ZMW4, B7ZMW5
    Conserved Domains (2) summary
    cd17659
    Location:94 → 386
    PTP_paladin_1; protein tyrosine phosphatase-like domain of paladin, repeat 1
    cd17660
    Location:480 → 737
    PTP_paladin_2; protein tyrosine phosphatase-like domain of paladin, repeat 2

RNA

  1. XR_004936190.1 RNA Sequence

  2. XR_380400.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P70261.1 GenPept UniProtKB/Swiss-Prot:P70261

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous