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RPS6KA6 ribosomal protein S6 kinase A6 [ Homo sapiens (human) ]

Gene ID: 27330, updated on 5-Mar-2024

Summary

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Official Symbol
RPS6KA6provided by HGNC
Official Full Name
ribosomal protein S6 kinase A6provided by HGNC
Primary source
HGNC:HGNC:10435
See related
Ensembl:ENSG00000072133 MIM:300303; AllianceGenome:HGNC:10435
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RSK4; RSK-4; p90RSK6; PP90RSK4; S6K-alpha-6
Summary
This gene encodes a member of ribosomal S6 kinase family, serine-threonine protein kinases which are regulated by growth factors. The encoded protein may be distinct from other members of this family, however, as studies suggest it is not growth factor dependent and may not participate in the same signaling pathways. [provided by RefSeq, Jan 2010]
Expression
Broad expression in thyroid (RPKM 5.0), kidney (RPKM 2.6) and 17 other tissues See more
Orthologs
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Genomic context

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See RPS6KA6 in Genome Data Viewer
Location:
Xq21.1
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (84058346..84188499, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (82493471..82624675, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (83313354..83443207, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene TERF1 pseudogene 4 Neighboring gene cylicin 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:83239627-83240128 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:83240129-83240628 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:83298980-83299480 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrX:83301391-83301957 Neighboring gene microRNA 548i-4 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chrX:83643706-83644905 Neighboring gene highly divergent homeobox

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. High RSK4 expression constitutes a predictor of poor prognosis for patients with clear cell renal carcinoma. Ma J, et al. Pathol Res Pract, 2021 Nov. PMID 34649054
  2. RSK4: a new prognostic factor in glioma. Chen L, et al. Pathol Res Pract, 2020 Aug. PMID 32703488
  3. Ribosomal S6 protein kinase 4 promotes radioresistance in esophageal squamous cell carcinoma. Li MY, et al. J Clin Invest, 2020 Aug 3. PMID 32396532, Free PMC Article
  4. Overexpression of RSK4 reverses doxorubicin resistance in human breast cancer cells via PI3K/AKT signalling pathway. Mei Y, et al. J Biochem, 2020 Jun 1. PMID 31960922
  5. Effect of RSK4 on biological characteristics of colorectal cancer. Ye Q, et al. World J Surg Oncol, 2018 Dec 22. PMID 30579335, Free PMC Article

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RSK4 promotes the macrophage recruitment and M2 polarization in esophageal squamous cell carcinoma.
    Title: RSK4 promotes the macrophage recruitment and M2 polarization in esophageal squamous cell carcinoma.
  2. Ribosomal S6 kinase 4 (RSK4) tumor suppressor gene promoter methylation status in ovarian cancer.
    Title: Ribosomal S6 kinase 4 (RSK4) tumor suppressor gene promoter methylation status in ovarian cancer.
  3. High RSK4 expression constitutes a predictor of poor prognosis for patients with clear cell renal carcinoma.
    Title: High RSK4 expression constitutes a predictor of poor prognosis for patients with clear cell renal carcinoma.
  4. RSK4: a new prognostic factor in glioma.
    Title: RSK4: a new prognostic factor in glioma.
  5. Hypermethylation of the RSK4 promoter associated with BRAF V600E promotes papillary thyroid carcinoma.
    Title: Hypermethylation of the RSK4 promoter associated with BRAF V600E promotes papillary thyroid carcinoma.
  6. Ribosomal S6 protein kinase 4 promotes radioresistance in esophageal squamous cell carcinoma.
    Title: Ribosomal S6 protein kinase 4 promotes radioresistance in esophageal squamous cell carcinoma.
  7. Overexpression of RSK4 reverses doxorubicin resistance in human breast cancer cells via PI3K/AKT signalling pathway.
    Title: Overexpression of RSK4 reverses doxorubicin resistance in human breast cancer cells via PI3K/AKT signalling pathway.
  8. E2 signaling may therefore act upstream of RSK4 to promote cancer progression. The results obtained in the current study suggested that RSK4 inhibited breast cancer cell invasiveness and that RSK4 promoter hypomethylation may serve as a novel prognostic marker for patients with breast cancer.
    Title: RSK4 inhibits breast cancer cell proliferation and invasion in vitro, and is correlated with estrogen receptor upregulation in breast cancer.
  9. High expression of RSK4 is associated with colorectal cancer.
    Title: Effect of RSK4 on biological characteristics of colorectal cancer.
  10. RSK4 constitutes a putative tumor suppressor gene for non-small cell lung carcinoma.
    Title: A Pilot Study of RSK4 Expression in Patients with Human Non-Small Cell Lung Carcinoma.
Submit: New GeneRIF Correction See all GeneRIFs (29)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity TAS
Traceable Author Statement
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables ribosomal protein S6 kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in central nervous system development TAS
Traceable Author Statement
more info
 PubMed 
involved_in negative regulation of ERK1 and ERK2 cascade ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of embryonic development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of mesoderm development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in fibrillar center IDA
Inferred from Direct Assay
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
ribosomal protein S6 kinase alpha-6
Names
90 kDa ribosomal protein S6 kinase 6
S6K-alpha 6
p90-RSK 6
ribosomal S6 kinase 4
ribosomal protein S6 kinase, 90kDa, polypeptide 6
NP_001317441.1
NP_055311.1
XP_011529219.1
XP_011529221.1
XP_011529222.1
XP_016884912.1
XP_016884913.1
XP_016884914.1
XP_047297952.1
XP_047297953.1
XP_054182821.1
XP_054182822.1
XP_054182823.1
XP_054182824.1
XP_054182825.1
XP_054182826.1
XP_054182827.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016340.1 RefSeqGene

    Range
    4737..134586
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001330512.1 → NP_001317441.1  ribosomal protein S6 kinase alpha-6 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes isoform 1.
    Source sequence(s)
    AL354653, AL389887, BC143648
    Consensus CDS
    CCDS83480.1
    UniProtKB/Swiss-Prot
    Q9UK32
    Conserved Domains (2) summary
    cd05582
    Location:77 → 391
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14177
    Location:421 → 715
    STKc_RSK4_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 4 (also called Ribosomal protein S6 kinase alpha-6 or 90kDa ribosomal protein S6 kinase 6)

  2. NM_014496.5 → NP_055311.1  ribosomal protein S6 kinase alpha-6 isoform 2

    See identical proteins and their annotated locations for NP_055311.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (2) is the same length as isoform 1, but has a distinct N-terminus.
    Source sequence(s)
    AF184965, AK313240, AL354653, AL389887, BQ448025
    Consensus CDS
    CCDS14451.1
    UniProtKB/Swiss-Prot
    B2R854, B7ZL90, Q6FHX2, Q8WX28, Q9H4S6, Q9UK32
    Related
    ENSP00000262752.2, ENST00000262752.5
    Conserved Domains (2) summary
    cd05582
    Location:77 → 391
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14177
    Location:421 → 715
    STKc_RSK4_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 4 (also called Ribosomal protein S6 kinase alpha-6 or 90kDa ribosomal protein S6 kinase 6)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    84058346..84188499 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047441997.1 → XP_047297953.1  ribosomal protein S6 kinase alpha-6 isoform X3

  2. XM_011530919.3 → XP_011529221.1  ribosomal protein S6 kinase alpha-6 isoform X4

    Conserved Domains (4) summary
    smart00220
    Location:1 → 227
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05582
    Location:1 → 288
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14177
    Location:318 → 612
    STKc_RSK4_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 4 (also called Ribosomal protein S6 kinase alpha-6 or 90kDa ribosomal protein S6 kinase 6)
    pfam00069
    Location:323 → 580
    Pkinase; Protein kinase domain

  3. XM_017029425.2 → XP_016884914.1  ribosomal protein S6 kinase alpha-6 isoform X1

  4. XM_047441996.1 → XP_047297952.1  ribosomal protein S6 kinase alpha-6 isoform X3

  5. XM_011530917.3 → XP_011529219.1  ribosomal protein S6 kinase alpha-6 isoform X2

    See identical proteins and their annotated locations for XP_011529219.1

    UniProtKB/Swiss-Prot
    Q9UK32
    Conserved Domains (2) summary
    cd05582
    Location:77 → 391
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14177
    Location:421 → 715
    STKc_RSK4_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 4 (also called Ribosomal protein S6 kinase alpha-6 or 90kDa ribosomal protein S6 kinase 6)

  6. XM_017029424.2 → XP_016884913.1  ribosomal protein S6 kinase alpha-6 isoform X1

  7. XM_017029423.2 → XP_016884912.1  ribosomal protein S6 kinase alpha-6 isoform X1

    Related
    ENSP00000483896.1, ENST00000620340.4

  8. XM_011530920.3 → XP_011529222.1  ribosomal protein S6 kinase alpha-6 isoform X5

    Conserved Domains (4) summary
    smart00220
    Location:1 → 209
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14177
    Location:300 → 594
    STKc_RSK4_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 4 (also called Ribosomal protein S6 kinase alpha-6 or 90kDa ribosomal protein S6 kinase 6)
    pfam00069
    Location:305 → 562
    Pkinase; Protein kinase domain
    cl21453
    Location:1 → 270
    PKc_like; Protein Kinases, catalytic domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    82493471..82624675 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054326851.1 → XP_054182826.1  ribosomal protein S6 kinase alpha-6 isoform X4

  2. XM_054326848.1 → XP_054182823.1  ribosomal protein S6 kinase alpha-6 isoform X1

  3. XM_054326850.1 → XP_054182825.1  ribosomal protein S6 kinase alpha-6 isoform X3

  4. XM_054326849.1 → XP_054182824.1  ribosomal protein S6 kinase alpha-6 isoform X2

  5. XM_054326847.1 → XP_054182822.1  ribosomal protein S6 kinase alpha-6 isoform X1

  6. XM_054326846.1 → XP_054182821.1  ribosomal protein S6 kinase alpha-6 isoform X1

  7. XM_054326852.1 → XP_054182827.1  ribosomal protein S6 kinase alpha-6 isoform X5

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UK32.1 GenPept UniProtKB/Swiss-Prot:Q9UK32

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