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ZNF544 zinc finger protein 544 [ Homo sapiens (human) ]

Gene ID: 27300, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF544provided by HGNC
Official Full Name
zinc finger protein 544provided by HGNC
Primary source
HGNC:HGNC:16759
See related
Ensembl:ENSG00000198131 AllianceGenome:HGNC:16759
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 3.1), testis (RPKM 3.0) and 25 other tissues See more
Orthologs
all
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Genomic context

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Location:
19q13.43
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (58228914..58277455)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (61325370..61373860)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (58740280..58788821)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372479 Neighboring gene ribosomal protein S15a pseudogene 36 Neighboring gene zinc finger protein 436 pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:58740156-58740982 Neighboring gene ZNF8 divergent transcript Neighboring gene ZNF8-ERVK3-1 readthrough (NMD candidate) Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15181 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15182 Neighboring gene zinc finger protein 8 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15183 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:58816949-58817449 Neighboring gene Sharpr-MPRA regulatory region 7439 Neighboring gene endogenous retrovirus group K3 member 1 Neighboring gene uncharacterized LOC105372480

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations. Lasky-Su J, et al. Am J Med Genet B Neuropsychiatr Genet, 2008 Dec 5. PMID 18821565
  2. HENA, heterogeneous network-based data set for Alzheimer's disease. Sügis E, et al. Sci Data, 2019 Aug 14. PMID 31413325, Free PMC Article
  3. SUMOylation of DDX39A Alters Binding and Export of Antiviral Transcripts to Control Innate Immunity. Shi P, et al. J Immunol, 2020 Jul 1. PMID 32393512
  4. Next-generation sequencing to generate interactome datasets. Yu H, et al. Nat Methods, 2011 Jun. PMID 21516116, Free PMC Article
  5. Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. Fei T, et al. Proc Natl Acad Sci U S A, 2017 Jun 27. PMID 28611215, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 544

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001320767.2 → NP_001307696.1  zinc finger protein 544 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-3 and 21-13 all encode the same isoform (1).
    Source sequence(s)
    AC020915, AL833618, BC067271, DA193549, DA342047
    Consensus CDS
    CCDS12973.1
    UniProtKB/Swiss-Prot
    A8K6J1, Q6NX49, Q9UEX4
    Conserved Domains (4) summary
    smart00349
    Location:14 → 73
    KRAB; krueppel associated box
    COG5048
    Location:406 → 699
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:494 → 514
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:370 → 391
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001320769.2 → NP_001307698.1  zinc finger protein 544 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-3 and 21-13 all encode the same isoform (1).
    Source sequence(s)
    AC020915, BC018980, DC310430
    Consensus CDS
    CCDS12973.1
    UniProtKB/Swiss-Prot
    A8K6J1, Q6NX49, Q9UEX4
    Conserved Domains (4) summary
    smart00349
    Location:14 → 73
    KRAB; krueppel associated box
    COG5048
    Location:406 → 699
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:494 → 514
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:370 → 391
    zf-H2C2_2; Zinc-finger double domain

  3. NM_001320770.2 → NP_001307699.1  zinc finger protein 544 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks an alternate in-frame exon in the coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1. Variants 4-6 all encode the same isoform (2).
    Source sequence(s)
    AK316446, AL833618, BC067271, DA193549
    Consensus CDS
    CCDS82413.1
    UniProtKB/TrEMBL
    J3KQC8
    Related
    ENSP00000472721.1, ENST00000600044.5
    Conserved Domains (5) summary
    smart00349
    Location:14 → 61
    KRAB; krueppel associated box
    COG5048
    Location:378 → 671
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:466 → 486
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:14 → 53
    KRAB; KRAB box
    pfam13465
    Location:450 → 475
    zf-H2C2_2; Zinc-finger double domain

  4. NM_001320771.2 → NP_001307700.1  zinc finger protein 544 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an alternate in-frame exon in the coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1. Variants 4-6 all encode the same isoform (2).
    Source sequence(s)
    AK296846, AL833618, BC067271, DA193549
    Consensus CDS
    CCDS82413.1
    UniProtKB/TrEMBL
    J3KQC8
    Related
    ENSP00000471684.1, ENST00000600220.5
    Conserved Domains (5) summary
    smart00349
    Location:14 → 61
    KRAB; krueppel associated box
    COG5048
    Location:378 → 671
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:466 → 486
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:14 → 53
    KRAB; KRAB box
    pfam13465
    Location:450 → 475
    zf-H2C2_2; Zinc-finger double domain

  5. NM_001320773.2 → NP_001307702.1  zinc finger protein 544 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and lacks an alternate in-frame exon in the coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1. Variants 4-6 all encode the same isoform (2).
    Source sequence(s)
    AC020915, AK296846, AL833618, BC018980, BC067271, DC310430
    Consensus CDS
    CCDS82413.1
    UniProtKB/TrEMBL
    J3KQC8
    Conserved Domains (5) summary
    smart00349
    Location:14 → 61
    KRAB; krueppel associated box
    COG5048
    Location:378 → 671
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:466 → 486
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:14 → 53
    KRAB; KRAB box
    pfam13465
    Location:450 → 475
    zf-H2C2_2; Zinc-finger double domain

  6. NM_001320774.2 → NP_001307703.1  zinc finger protein 544 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and uses an alternate in-frame splice site in the 3' terminal exon, compared to variant 1. It encodes isoform 3, which is shorter than isoform 1. Variants 7 and 24 both encode the same isoform (3).
    Source sequence(s)
    AC020915, BC018980, DC310430
    Conserved Domains (4) summary
    smart00349
    Location:14 → 73
    KRAB; krueppel associated box
    COG5048
    Location:171 → 464
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:259 → 279
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:135 → 156
    zf-H2C2_2; Zinc-finger double domain

  7. NM_001320776.2 → NP_001307705.1  zinc finger protein 544 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) has multiple differences compared to variant 1. These differences result in distinct 5' and 3' UTRs and cause translation initiation at an alternate start site, compared to variant 1. The encoded protein (isoform 4) is shorter and has distinct N- and C-termini, compared to isoform 1.
    Source sequence(s)
    AC020915, AK291656, BU626073, DA193549
    UniProtKB/Swiss-Prot
    Q6NX49
    Conserved Domains (3) summary
    smart00349
    Location:68 → 107
    KRAB; krueppel associated box
    pfam01352
    Location:68 → 107
    KRAB; KRAB box
    pfam13900
    Location:130 → 151
    GVQW; Putative domain of unknown function

  8. NM_001320777.2 → NP_001307706.1  zinc finger protein 544 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) has multiple differences compared to variant 1. These differences result in distinct 5' and 3' UTRs and cause translation initiation at an alternate start site, compared to variant 1. The encoded protein (isoform 5) is shorter and has distinct N- and C-termini, compared to isoform 1.
    Source sequence(s)
    AC020915, AL833618, BC067271, DA193549, DB200767
    UniProtKB/Swiss-Prot
    Q6NX49
    Conserved Domains (2) summary
    smart00349
    Location:68 → 107
    KRAB; krueppel associated box
    pfam01352
    Location:68 → 107
    KRAB; KRAB box

  9. NM_001320780.2 → NP_001307709.1  zinc finger protein 544 isoform 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) contains an alternate 3' terminal exon, compared to variant 1. It encodes a shorter isoform (6) which has a distinct C-terminus, compared to isoform 1. Variants 10, 25, and 26 all encode the same isoform (6).
    Source sequence(s)
    AC020915, AK291656, BU626073, DA193549
    UniProtKB/Swiss-Prot
    Q6NX49
    Conserved Domains (1) summary
    smart00349
    Location:14 → 73
    KRAB; krueppel associated box

  10. NM_001320781.2 → NP_001307710.1  zinc finger protein 544 isoform 7

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11) has multiple differences compared to variant 1. These differences result in distinct 5' and 3' UTRs and cause translation initiation at an alternate start site, compared to variant 1. The encoded protein (isoform 7) is shorter and has distinct N- and C-termini, compared to isoform 1. Variants 11 and 27 both encode the same isoform (7).
    Source sequence(s)
    AC020915, BC018980, DC310430
    Conserved Domains (1) summary
    smart00349
    Location:68 → 107
    KRAB; krueppel associated box

  11. NM_001320782.3 → NP_001307711.1  zinc finger protein 544 isoform 8

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12) contains an alternate 3' terminal exon, compared to variant 1. It encodes a shorter isoform (8) which has a distinct C-terminus, compared to isoform 1. Variants 12, 29, 30, and 33 all encode the same isoform (8).
    Source sequence(s)
    AC020915
    Consensus CDS
    CCDS82411.1
    UniProtKB/TrEMBL
    M0QX86, M0QZM7
    Related
    ENSP00000470645.1, ENST00000596929.5
    Conserved Domains (1) summary
    smart00349
    Location:14 → 73
    KRAB; krueppel associated box

  12. NM_001320783.2 → NP_001307712.1  zinc finger protein 544 isoform 9

    Status: VALIDATED

    Description
    Transcript Variant: This variant (13) has multiple differences compared to variant 1. These differences result in distinct 5' and 3' UTRs and cause translation initiation at an alternate start site, compared to variant 1. The encoded protein (isoform 9) is shorter and has distinct N- and C-termini, compared to isoform 1. Variants 13 and 28 both encode the same isoform (9).
    Source sequence(s)
    AC020915, AK291656, BU626073
    UniProtKB/Swiss-Prot
    Q6NX49
    Conserved Domains (1) summary
    smart00349
    Location:14 → 53
    KRAB; krueppel associated box

  13. NM_001320785.2 → NP_001307714.1  zinc finger protein 544 isoform 10

    Status: VALIDATED

    Description
    Transcript Variant: This variant (14) uses alternate splice sites in the penultimate and 3' terminal exons, compared to variant 1. It encodes isoform 10 which is shorter and has a distinct C-terminus, compared to isoform 1. Variants 14-16 and 35 all encode the same isoform (10).
    Source sequence(s)
    AL833618, BC067271, DA193549, DB200767
    UniProtKB/TrEMBL
    A0A1B0GV72
    Conserved Domains (1) summary
    smart00349
    Location:14 → 53
    KRAB; krueppel associated box

  14. NM_001320786.2 → NP_001307715.1  zinc finger protein 544 isoform 10

    Status: VALIDATED

    Description
    Transcript Variant: This variant (15) differs in the 5' UTR and uses alternate splice sites in the penultimate and 3' terminal exons, compared to variant 1. It encodes isoform 10 which is shorter and has a distinct C-terminus, compared to isoform 1. Variants 14-16 and 35 all encode the same isoform (10).
    Source sequence(s)
    AC020915, AL833618, BC067271, DA193549, DB200767
    UniProtKB/TrEMBL
    A0A1B0GV72
    Conserved Domains (1) summary
    smart00349
    Location:14 → 53
    KRAB; krueppel associated box

  15. NM_001320787.2 → NP_001307716.1  zinc finger protein 544 isoform 10

    Status: VALIDATED

    Description
    Transcript Variant: This variant (16) differs in the 5' UTR and uses alternate splice sites in the penultimate and 3' terminal exons, compared to variant 1. It encodes isoform 10 which is shorter and has a distinct C-terminus, compared to isoform 1. Variants 14-16 and 35 all encode the same isoform (10).
    Source sequence(s)
    AC020915, BC018980, DC310430
    UniProtKB/TrEMBL
    A0A1B0GV72
    Conserved Domains (1) summary
    smart00349
    Location:14 → 53
    KRAB; krueppel associated box

  16. NM_001320788.2 → NP_001307717.1  zinc finger protein 544 isoform 11

    Status: VALIDATED

    Description
    Transcript Variant: This variant (17) uses an alternate splice site in the penultimate exon, compared to variant 1. It encodes isoform 11 which is shorter and has a distinct C-terminus, compared to isoform 1. Variants 17-20, 36, and 37 all encode the same isoform (11).
    Source sequence(s)
    AC020915, AL833618, DA193549
    Consensus CDS
    CCDS82412.1
    UniProtKB/TrEMBL
    A0A1B0GV72, M0R2F0
    Related
    ENSP00000471480.1, ENST00000599227.5
    Conserved Domains (1) summary
    smart00349
    Location:14 → 53
    KRAB; krueppel associated box

  17. NM_001320789.2 → NP_001307718.1  zinc finger protein 544 isoform 11

    Status: VALIDATED

    Description
    Transcript Variant: This variant (18) differs in the 5' UTR and uses an alternate splice site in the penultimate exon, compared to variant 1. It encodes isoform 11 which is shorter and has a distinct C-terminus, compared to isoform 1. Variants 17-20, 36, and 37 all encode the same isoform (11).
    Source sequence(s)
    AC020915, BC018980, DC310430
    Consensus CDS
    CCDS82412.1
    UniProtKB/TrEMBL
    A0A1B0GV72, M0R2F0
    Related
    ENSP00000472512.1, ENST00000596825.5
    Conserved Domains (1) summary
    smart00349
    Location:14 → 53
    KRAB; krueppel associated box

  18. NM_001320791.2 → NP_001307720.1  zinc finger protein 544 isoform 11

    Status: VALIDATED

    Description
    Transcript Variant: This variant (19) differs in the 5' UTR and uses an alternate splice site in the penultimate exon, compared to variant 1. It encodes isoform 11 which is shorter and has a distinct C-terminus, compared to isoform 1. Variants 17-20, 36, and 37 all encode the same isoform (11).
    Source sequence(s)
    AL833618, BC067271, DA193549, DA342047
    Consensus CDS
    CCDS82412.1
    UniProtKB/TrEMBL
    A0A1B0GV72, M0R2F0
    Conserved Domains (1) summary
    smart00349
    Location:14 → 53
    KRAB; krueppel associated box

  19. NM_001320792.2 → NP_001307721.1  zinc finger protein 544 isoform 11

    Status: VALIDATED

    Description
    Transcript Variant: This variant (20) differs in the 5' UTR and uses an alternate splice site in the penultimate exon, compared to variant 1. It encodes isoform 11 which is shorter and has a distinct C-terminus, compared to isoform 1. Variants 17-20, 36, and 37 all encode the same isoform (11).
    Source sequence(s)
    AC020915, AL833618, DA193549
    Consensus CDS
    CCDS82412.1
    UniProtKB/TrEMBL
    A0A1B0GV72, M0R2F0
    Conserved Domains (1) summary
    smart00349
    Location:14 → 53
    KRAB; krueppel associated box

  20. NM_001387390.1 → NP_001374319.1  zinc finger protein 544 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (21), as well as variants 1-3, 22, and 23, encodes isoform 1.
    Source sequence(s)
    AC020915
    Consensus CDS
    CCDS12973.1
    UniProtKB/Swiss-Prot
    A8K6J1, Q6NX49, Q9UEX4
    Related
    ENSP00000269829.4, ENST00000269829.5
    Conserved Domains (4) summary
    smart00349
    Location:14 → 73
    KRAB; krueppel associated box
    COG5048
    Location:406 → 699
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:494 → 514
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:370 → 391
    zf-H2C2_2; Zinc-finger double domain

  21. NM_001387391.1 → NP_001374320.1  zinc finger protein 544 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (22), as well as variants 1-3, 21, and 23, encodes isoform 1.
    Source sequence(s)
    AC020915
    Consensus CDS
    CCDS12973.1
    UniProtKB/Swiss-Prot
    A8K6J1, Q6NX49, Q9UEX4
    Conserved Domains (4) summary
    smart00349
    Location:14 → 73
    KRAB; krueppel associated box
    COG5048
    Location:406 → 699
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:494 → 514
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:370 → 391
    zf-H2C2_2; Zinc-finger double domain

  22. NM_001387392.1 → NP_001374321.1  zinc finger protein 544 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (23), as well as variants 1-3, 21, and 22, encodes isoform 1.
    Source sequence(s)
    AC020915
    Consensus CDS
    CCDS12973.1
    UniProtKB/Swiss-Prot
    A8K6J1, Q6NX49, Q9UEX4
    Conserved Domains (4) summary
    smart00349
    Location:14 → 73
    KRAB; krueppel associated box
    COG5048
    Location:406 → 699
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:494 → 514
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:370 → 391
    zf-H2C2_2; Zinc-finger double domain

  23. NM_001387393.1 → NP_001374322.1  zinc finger protein 544 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (24), as well as variant 7, encodes isoform 3.
    Source sequence(s)
    AC020915
    Conserved Domains (4) summary
    smart00349
    Location:14 → 73
    KRAB; krueppel associated box
    COG5048
    Location:171 → 464
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:259 → 279
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:135 → 156
    zf-H2C2_2; Zinc-finger double domain

  24. NM_001387394.1 → NP_001374323.1  zinc finger protein 544 isoform 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (25), as well as variants 10 and 26, encodes isoform 6.
    Source sequence(s)
    AC020915
    Conserved Domains (1) summary
    smart00349
    Location:14 → 73
    KRAB; krueppel associated box

  25. NM_001387395.1 → NP_001374324.1  zinc finger protein 544 isoform 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (26), as well as variants 10 and 25, encodes isoform 6.
    Source sequence(s)
    AC020915
    Conserved Domains (1) summary
    smart00349
    Location:14 → 73
    KRAB; krueppel associated box

  26. NM_001387396.1 → NP_001374325.1  zinc finger protein 544 isoform 7

    Status: VALIDATED

    Description
    Transcript Variant: This variant (27), as well as variant 11, encodes isoform 7.
    Source sequence(s)
    AC020915
    Conserved Domains (1) summary
    smart00349
    Location:68 → 107
    KRAB; krueppel associated box

  27. NM_001387397.1 → NP_001374326.1  zinc finger protein 544 isoform 9

    Status: VALIDATED

    Description
    Transcript Variant: This variant (28), as well as variant 13, encodes isoform 9.
    Source sequence(s)
    AC020915
    Conserved Domains (1) summary
    smart00349
    Location:14 → 53
    KRAB; krueppel associated box

  28. NM_001387398.1 → NP_001374327.1  zinc finger protein 544 isoform 8

    Status: VALIDATED

    Description
    Transcript Variant: This variant (29), as well as variants 12, 30, and 33, encodes isoform 8.
    Source sequence(s)
    AC020915
    Consensus CDS
    CCDS82411.1
    UniProtKB/TrEMBL
    M0QX86, M0QZM7
    Conserved Domains (1) summary
    smart00349
    Location:14 → 73
    KRAB; krueppel associated box

  29. NM_001387399.1 → NP_001374328.1  zinc finger protein 544 isoform 8

    Status: VALIDATED

    Description
    Transcript Variant: This variant (30), as well as variants 12, 29, and 33, encodes isoform 8.
    Source sequence(s)
    AC020915
    Consensus CDS
    CCDS82411.1
    UniProtKB/TrEMBL
    M0QX86, M0QZM7
    Conserved Domains (1) summary
    smart00349
    Location:14 → 73
    KRAB; krueppel associated box

  30. NM_001387400.1 → NP_001374329.1  zinc finger protein 544 isoform 8

    Status: VALIDATED

    Description
    Transcript Variant: This variant (33), as well as variants 12, 29, and 30, encodes isoform 8.
    Source sequence(s)
    AC020915
    Consensus CDS
    CCDS82411.1
    UniProtKB/TrEMBL
    M0QX86, M0QZM7
    Conserved Domains (1) summary
    smart00349
    Location:14 → 73
    KRAB; krueppel associated box

  31. NM_001387401.1 → NP_001374330.1  zinc finger protein 544 isoform 26

    Status: VALIDATED

    Description
    Transcript Variant: This variant (31), as well as variants 32 and 34, encodes isoform 26.
    Source sequence(s)
    AC020915
    UniProtKB/TrEMBL
    M0QX86
    Conserved Domains (1) summary
    smart00349
    Location:14 → 73
    KRAB; krueppel associated box

  32. NM_001387402.1 → NP_001374331.1  zinc finger protein 544 isoform 26

    Status: VALIDATED

    Description
    Transcript Variant: This variant (32), as well as variants 31 and 34, encodes isoform 26.
    Source sequence(s)
    AC020915
    UniProtKB/TrEMBL
    M0QX86
    Conserved Domains (1) summary
    smart00349
    Location:14 → 73
    KRAB; krueppel associated box

  33. NM_001387403.1 → NP_001374332.1  zinc finger protein 544 isoform 26

    Status: VALIDATED

    Description
    Transcript Variant: This variant (34), as well as variants 31 and 32, encodes isoform 26.
    Source sequence(s)
    AC020915
    UniProtKB/TrEMBL
    M0QX86
    Conserved Domains (1) summary
    smart00349
    Location:14 → 73
    KRAB; krueppel associated box

  34. NM_001387407.1 → NP_001374336.1  zinc finger protein 544 isoform 10

    Status: VALIDATED

    Description
    Transcript Variant: This variant (35), as well as variants 14-16, encodes isoform 10.
    Source sequence(s)
    AC020915
    UniProtKB/TrEMBL
    A0A1B0GV72
    Conserved Domains (1) summary
    smart00349
    Location:14 → 53
    KRAB; krueppel associated box

  35. NM_001387408.1 → NP_001374337.1  zinc finger protein 544 isoform 11

    Status: VALIDATED

    Description
    Transcript Variant: This variant (36), as well as variants 17-20 and 37, encodes isoform 11.
    Source sequence(s)
    AC020915
    Consensus CDS
    CCDS82412.1
    UniProtKB/TrEMBL
    A0A1B0GV72, M0R2F0
    Related
    ENSP00000498814.1, ENST00000652201.1
    Conserved Domains (1) summary
    smart00349
    Location:14 → 53
    KRAB; krueppel associated box

  36. NM_001387409.1 → NP_001374338.1  zinc finger protein 544 isoform 11

    Status: VALIDATED

    Description
    Transcript Variant: This variant (37), as well as variants 17-20 and 36, encodes isoform 11.
    Source sequence(s)
    AC020915
    Consensus CDS
    CCDS82412.1
    UniProtKB/TrEMBL
    A0A1B0GV72, M0R2F0
    Conserved Domains (1) summary
    smart00349
    Location:14 → 53
    KRAB; krueppel associated box

  37. NM_001387410.1 → NP_001374339.1  zinc finger protein 544 isoform 12

    Status: VALIDATED

    Description
    Transcript Variant: This variant (38) encodes the longest isoform (12). Variants 38 and 39 both encode the same isoform (12).
    Source sequence(s)
    AC020915
    Conserved Domains (4) summary
    smart00349
    Location:68 → 127
    KRAB; krueppel associated box
    COG5048
    Location:460 → 753
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:548 → 568
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:424 → 445
    zf-H2C2_2; Zinc-finger double domain

  38. NM_001387413.1 → NP_001374342.1  zinc finger protein 544 isoform 12

    Status: VALIDATED

    Description
    Transcript Variant: This variant (39) encodes the longest isoform (12). Variants 38 and 39 both encode the same isoform (12).
    Source sequence(s)
    AC020915
    Conserved Domains (4) summary
    smart00349
    Location:68 → 127
    KRAB; krueppel associated box
    COG5048
    Location:460 → 753
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:548 → 568
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:424 → 445
    zf-H2C2_2; Zinc-finger double domain

  39. NM_001387415.1 → NP_001374344.1  zinc finger protein 544 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AC020915
    Conserved Domains (4) summary
    smart00349
    Location:1 → 53
    KRAB; krueppel associated box
    COG5048
    Location:386 → 679
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:474 → 494
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:350 → 371
    zf-H2C2_2; Zinc-finger double domain

  40. NM_001387416.1 → NP_001374345.1  zinc finger protein 544 isoform 14

    Status: VALIDATED

    Source sequence(s)
    AC020915
    Conserved Domains (1) summary
    smart00349
    Location:68 → 127
    KRAB; krueppel associated box

  41. NM_001387417.1 → NP_001374346.1  zinc finger protein 544 isoform 15

    Status: VALIDATED

    Source sequence(s)
    AC020915
    Conserved Domains (1) summary
    smart00349
    Location:68 → 127
    KRAB; krueppel associated box

  42. NM_001387418.1 → NP_001374347.1  zinc finger protein 544 isoform 16

    Status: VALIDATED

    Description
    Transcript Variant: This variant (43), as well as variant 44, encodes isoform 16.
    Source sequence(s)
    AC020915
    Consensus CDS
    CCDS92700.1
    UniProtKB/TrEMBL
    M0QZY0
    Related
    ENSP00000470843.1, ENST00000595981.5
    Conserved Domains (1) summary
    smart00349
    Location:14 → 73
    KRAB; krueppel associated box

  43. NM_001387419.1 → NP_001374348.1  zinc finger protein 544 isoform 16

    Status: VALIDATED

    Description
    Transcript Variant: This variant (44), as well as variant 43, encodes isoform 16.
    Source sequence(s)
    AC020915
    Consensus CDS
    CCDS92700.1
    UniProtKB/TrEMBL
    M0QZY0
    Conserved Domains (1) summary
    smart00349
    Location:14 → 73
    KRAB; krueppel associated box

  44. NM_001387420.1 → NP_001374349.1  zinc finger protein 544 isoform 17

    Status: VALIDATED

    Source sequence(s)
    AC020915
    Conserved Domains (1) summary
    smart00349
    Location:68 → 107
    KRAB; krueppel associated box

  45. NM_001387421.1 → NP_001374350.1  zinc finger protein 544 isoform 18

    Status: VALIDATED

    Source sequence(s)
    AC020915
    Conserved Domains (1) summary
    smart00349
    Location:14 → 53
    KRAB; krueppel associated box

  46. NM_001387422.1 → NP_001374351.1  zinc finger protein 544 isoform 19

    Status: VALIDATED

    Source sequence(s)
    AC020915
    UniProtKB/TrEMBL
    M0QX86
    Conserved Domains (1) summary
    smart00349
    Location:14 → 73
    KRAB; krueppel associated box

  47. NM_001387423.1 → NP_001374352.1  zinc finger protein 544 isoform 20

    Status: VALIDATED

    Description
    Transcript Variant: This variant (48), as well as variants 49 and 50, encodes isoform 20.
    Source sequence(s)
    AC020915
    UniProtKB/TrEMBL
    M0QX86
    Conserved Domains (1) summary
    smart00349
    Location:14 → 73
    KRAB; krueppel associated box

  48. NM_001387424.1 → NP_001374353.1  zinc finger protein 544 isoform 20

    Status: VALIDATED

    Description
    Transcript Variant: This variant (49), as well as variants 48 and 50, encodes isoform 20.
    Source sequence(s)
    AC020915
    UniProtKB/TrEMBL
    M0QX86
    Conserved Domains (1) summary
    smart00349
    Location:14 → 73
    KRAB; krueppel associated box

  49. NM_001387425.1 → NP_001374354.1  zinc finger protein 544 isoform 20

    Status: VALIDATED

    Description
    Transcript Variant: This variant (50), as well as variants 48 and 49, encodes isoform 20.
    Source sequence(s)
    AC020915
    UniProtKB/TrEMBL
    M0QX86
    Conserved Domains (1) summary
    smart00349
    Location:14 → 73
    KRAB; krueppel associated box

  50. NM_001387426.1 → NP_001374355.1  zinc finger protein 544 isoform 21

    Status: VALIDATED

    Description
    Transcript Variant: This variant (51), as well as variants 52 and 53, encodes isoform 21.
    Source sequence(s)
    AC020915
    UniProtKB/TrEMBL
    A0A1B0GV72
    Conserved Domains (1) summary
    smart00349
    Location:14 → 53
    KRAB; krueppel associated box

  51. NM_001387427.1 → NP_001374356.1  zinc finger protein 544 isoform 21

    Status: VALIDATED

    Description
    Transcript Variant: This variant (52), as well as variants 51 and 53, encodes isoform 21.
    Source sequence(s)
    AC020915
    UniProtKB/TrEMBL
    A0A1B0GV72
    Conserved Domains (1) summary
    smart00349
    Location:14 → 53
    KRAB; krueppel associated box

  52. NM_001387428.1 → NP_001374357.1  zinc finger protein 544 isoform 21

    Status: VALIDATED

    Description
    Transcript Variant: This variant (53), as well as variants 51 and 52, encodes isoform 21.
    Source sequence(s)
    AC020915
    UniProtKB/TrEMBL
    A0A1B0GV72
    Conserved Domains (1) summary
    smart00349
    Location:14 → 53
    KRAB; krueppel associated box

  53. NM_001387429.1 → NP_001374358.1  zinc finger protein 544 isoform 22

    Status: VALIDATED

    Description
    Transcript Variant: This variant (54), as well as variants 55-57, encodes isoform 22.
    Source sequence(s)
    AC020915
    UniProtKB/TrEMBL
    M0QX86
    Conserved Domains (1) summary
    smart00349
    Location:14 → 73
    KRAB; krueppel associated box

  54. NM_001387431.1 → NP_001374360.1  zinc finger protein 544 isoform 22

    Status: VALIDATED

    Description
    Transcript Variant: This variant (55), as well as variants 54, 56, and 57, encodes isoform 22.
    Source sequence(s)
    AC020915
    UniProtKB/TrEMBL
    M0QX86
    Conserved Domains (1) summary
    smart00349
    Location:14 → 73
    KRAB; krueppel associated box

  55. NM_001387432.1 → NP_001374361.1  zinc finger protein 544 isoform 22

    Status: VALIDATED

    Description
    Transcript Variant: This variant (56), as well as variants 54, 55, and 57, encodes isoform 22.
    Source sequence(s)
    AC020915
    UniProtKB/TrEMBL
    M0QX86
    Related
    ENSP00000468975.1, ENST00000597240.5
    Conserved Domains (1) summary
    smart00349
    Location:14 → 73
    KRAB; krueppel associated box

  56. NM_001387433.1 → NP_001374362.1  zinc finger protein 544 isoform 22

    Status: VALIDATED

    Description
    Transcript Variant: This variant (57), as well as variants 54-56, encodes isoform 22.
    Source sequence(s)
    AC020915
    UniProtKB/TrEMBL
    M0QX86
    Conserved Domains (1) summary
    smart00349
    Location:14 → 73
    KRAB; krueppel associated box

  57. NM_001387434.1 → NP_001374363.1  zinc finger protein 544 isoform 23

    Status: VALIDATED

    Source sequence(s)
    AC020915
    Consensus CDS
    CCDS92701.1
    UniProtKB/TrEMBL
    A0A1B0GV72, M0R0U7
    Related
    ENSP00000471452.1, ENST00000596677.5
    Conserved Domains (1) summary
    smart00349
    Location:14 → 53
    KRAB; krueppel associated box

  58. NM_001387435.1 → NP_001374364.1  zinc finger protein 544 isoform 24

    Status: VALIDATED

    Source sequence(s)
    AC020915
    UniProtKB/TrEMBL
    A0A1B0GV72
    Conserved Domains (1) summary
    smart00349
    Location:14 → 53
    KRAB; krueppel associated box

  59. NM_001387436.1 → NP_001374365.1  zinc finger protein 544 isoform 25

    Status: VALIDATED

    Source sequence(s)
    AC020915
    UniProtKB/TrEMBL
    A0A1B0GVN2
    Conserved Domains (1) summary
    cl02581
    Location:14 → 42
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

  60. NM_001412174.1 → NP_001399103.1  zinc finger protein 544 isoform 27

    Status: VALIDATED

    Description
    Transcript Variant: This variant (60) represents an alternate allele of variant 46 on T2T-CHM13v2.0 assembly. It contains a frameshift in the 3' CDS compared to variant 46, and encodes isoform 26, which has a shorter and different C-terminus compared to isoform 18.
    Source sequence(s)
    CP068259

  61. NM_014480.4 → NP_055295.2  zinc finger protein 544 isoform 1

    See identical proteins and their annotated locations for NP_055295.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1. Variants 1-3 and 21-23 all encode the same isoform (1).
    Source sequence(s)
    AK291656, AL833618, BC067271, DA193549
    Consensus CDS
    CCDS12973.1
    UniProtKB/Swiss-Prot
    A8K6J1, Q6NX49, Q9UEX4
    Related
    ENSP00000510489.1, ENST00000687789.1
    Conserved Domains (4) summary
    smart00349
    Location:14 → 73
    KRAB; krueppel associated box
    COG5048
    Location:406 → 699
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:494 → 514
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:370 → 391
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    58228914..58277455
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    61325370..61373860
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6NX49.1 GenPept UniProtKB/Swiss-Prot:Q6NX49

Gene LinkOut

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