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Tnfrsf12a tumor necrosis factor receptor superfamily, member 12a [ Mus musculus (house mouse) ]

Gene ID: 27279, updated on 21-Apr-2024

Summary

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Official Symbol
Tnfrsf12aprovided by MGI
Official Full Name
tumor necrosis factor receptor superfamily, member 12aprovided by MGI
Primary source
MGI:MGI:1351484
See related
Ensembl:ENSMUSG00000023905 AllianceGenome:MGI:1351484
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fn14; HPIP; TweakR; TWEAK-R
Summary
Involved in regulation of angiogenesis. Acts upstream of or within extrinsic apoptotic signaling pathway; positive regulation of axon extension; and substrate-dependent cell migration, cell attachment to substrate. Located in cell surface; plasma membrane; and ruffle. Is expressed in several structures, including adrenal medulla; genitourinary system; heart; limb long bone; and molar. Orthologous to human TNFRSF12A (TNF receptor superfamily member 12A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in adrenal adult (RPKM 44.7), ovary adult (RPKM 38.8) and 18 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 A3.3; 17 11.99 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (23894419..23896423, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (23675445..23677449, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene matrix metallopeptidase 25 Neighboring gene ribosomal protein L36 pseudogene Neighboring gene BICD family like cargo adaptor 2 Neighboring gene STARR-positive B cell enhancer ABC_E8656 Neighboring gene THO complex 6 Neighboring gene host cell factor C1 regulator 1 (XPO1-dependent) Neighboring gene claudin 6 Neighboring gene claudin 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. TWEAK/FN14 promotes profibrogenic pathway activation in Prominin-1-expressing hepatic progenitor cells in biliary atresia. Short C, et al. Hepatology, 2023 May 1. PMID 36626628
  2. Targeted ablation of Fn14 receptor improves exercise capacity and inhibits neurogenic muscle atrophy. Tomaz da Silva M, et al. FASEB J, 2022 Dec. PMID 36412933, Free PMC Article
  3. Fn14 exacerbates acute lung injury by activating the NLRP3 inflammasome in mice. Guan XX, et al. Mol Med, 2022 Jul 30. PMID 35907805, Free PMC Article
  4. Inhibition of fibroblast growth factor-inducible 14 attenuates experimental tubulointerstitial fibrosis and profibrotic factor expression of proximal tubular epithelial cells. Luo M, et al. Inflamm Res, 2021 May. PMID 33755760
  5. Developmental synaptic regulator, TWEAK/Fn14 signaling, is a determinant of synaptic function in models of stroke and neurodegeneration. Nagy D, et al. Proc Natl Acad Sci U S A, 2021 Feb 9. PMID 33526652, Free PMC Article

See all (104) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tweak/Fn14 system is involved in rhabdomyolysis-induced acute kidney injury.
    Title: Tweak/Fn14 system is involved in rhabdomyolysis-induced acute kidney injury.
  2. Fn14 promotes myoblast fusion during regenerative myogenesis.
    Title: Fn14 promotes myoblast fusion during regenerative myogenesis.
  3. Alpha-Ketoglutarate Regulates Tnfrsf12a/Fn14 Expression via Histone Modification and Prevents Cancer-Induced Cachexia.
    Title: Alpha-Ketoglutarate Regulates Tnfrsf12a/Fn14 Expression via Histone Modification and Prevents Cancer-Induced Cachexia.
  4. TWEAK/FN14 promotes profibrogenic pathway activation in Prominin-1-expressing hepatic progenitor cells in biliary atresia.
    Title: TWEAK/FN14 promotes profibrogenic pathway activation in Prominin-1-expressing hepatic progenitor cells in biliary atresia.
  5. Conjugation of the Fn14 Ligand to a SMAC Mimetic Selectively Suppresses Experimental Squamous Cell Carcinoma in Mice.
    Title: Conjugation of the Fn14 Ligand to a SMAC Mimetic Selectively Suppresses Experimental Squamous Cell Carcinoma in Mice.
  6. Targeted ablation of Fn14 receptor improves exercise capacity and inhibits neurogenic muscle atrophy.
    Title: Targeted ablation of Fn14 receptor improves exercise capacity and inhibits neurogenic muscle atrophy.
  7. Fn14 exacerbates acute lung injury by activating the NLRP3 inflammasome in mice.
    Title: Fn14 exacerbates acute lung injury by activating the NLRP3 inflammasome in mice.
  8. Dysregulation of Tweak and Fn14 in skeletal muscle of spinal muscular atrophy mice.
    Title: Dysregulation of Tweak and Fn14 in skeletal muscle of spinal muscular atrophy mice.
  9. Inhibition of fibroblast growth factor-inducible 14 attenuates experimental tubulointerstitial fibrosis and profibrotic factor expression of proximal tubular epithelial cells.
    Title: Inhibition of fibroblast growth factor-inducible 14 attenuates experimental tubulointerstitial fibrosis and profibrotic factor expression of proximal tubular epithelial cells.
  10. TWEAK Signaling Pathway Blockade Slows Cyst Growth and Disease Progression in Autosomal Dominant Polycystic Kidney Disease.
    Title: TWEAK Signaling Pathway Blockade Slows Cyst Growth and Disease Progression in Autosomal Dominant Polycystic Kidney Disease.
Submit: New GeneRIF Correction See all GeneRIFs (65)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within angiogenesis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within extrinsic apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of axon extension IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of extrinsic apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of angiogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of wound healing ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within substrate-dependent cell migration, cell attachment to substrate IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in ruffle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
tumor necrosis factor receptor superfamily member 12A
Names
FGF-inducible 14
fibroblast growth factor-inducible immediate-early response protein 14
fibroblast growth factor-regulated protein 2
tweak-receptor
type I transmembrane protein Fn14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001161746.1 → NP_001155218.1  tumor necrosis factor receptor superfamily member 12A isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AI853177, AK160136, DV655788
    Consensus CDS
    CCDS50011.1
    UniProtKB/TrEMBL
    E9PZT5
    Related
    ENSMUSP00000131574.2, ENSMUST00000167059.9
    Conserved Domains (1) summary
    cl22855
    Location:1 → 94
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

  2. NM_013749.2 → NP_038777.2  tumor necrosis factor receptor superfamily member 12A isoform 1 precursor

    See identical proteins and their annotated locations for NP_038777.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AI853177, AK160136
    Consensus CDS
    CCDS28456.1
    UniProtKB/Swiss-Prot
    Q3TVG8, Q9CR75, Q9QZW3
    Related
    ENSMUSP00000024698.9, ENSMUST00000024698.10
    Conserved Domains (2) summary
    cd13413
    Location:9 → 33
    TNFRSF12A; CRD1 [structural motif]
    cl22855
    Location:1 → 129
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    23894419..23896423 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CR75.1 GenPept UniProtKB/Swiss-Prot:Q9CR75

Gene LinkOut

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