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Cars1 cysteinyl-tRNA synthetase 1 [ Mus musculus (house mouse) ]

Gene ID: 27267, updated on 5-Mar-2024

Summary

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Official Symbol
Cars1provided by MGI
Official Full Name
cysteinyl-tRNA synthetase 1provided by MGI
Primary source
MGI:MGI:1351477
See related
Ensembl:ENSMUSG00000010755 AllianceGenome:MGI:1351477
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CA3; Cars
Summary
Predicted to enable several functions, including ATP binding activity; cysteine-tRNA ligase activity; and protein homodimerization activity. Predicted to be involved in cysteinyl-tRNA aminoacylation. Predicted to act upstream of or within translation. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human CARS1 (cysteinyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 11.8), liver E14 (RPKM 11.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 F5; 7 88.25 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (143110967..143153827, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (143557230..143600090, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene pleckstrin homology like domain, family A, member 2 Neighboring gene nucleosome assembly protein 1-like 4 Neighboring gene predicted gene, 23297 Neighboring gene STARR-positive B cell enhancer ABC_E1362 Neighboring gene microRNA 7064 Neighboring gene STARR-seq mESC enhancer starr_20532 Neighboring gene STARR-seq mESC enhancer starr_20533 Neighboring gene STARR-positive B cell enhancer ABC_E1098 Neighboring gene predicted gene 15580 Neighboring gene predicted gene 15579 Neighboring gene tumor necrosis factor receptor superfamily, member 26

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Genes induced by growth arrest in a pancreatic beta cell line: identification by analysis of cDNA arrays. Zimmer Y, et al. FEBS Lett, 1999 Aug 20. PMID 10486565
  2. Sequence comparisons and functional studies of the proximal promoter of the carbonic anhydrase 3 (CA3) gene. Sowden J, et al. Gene, 1998 Jul 3. PMID 9651514
  3. Identification of a new murine tumor necrosis factor receptor locus that contains two novel murine receptors for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). Schneider P, et al. J Biol Chem, 2003 Feb 14. PMID 12466268
  4. Sequence-based structural features between Kvlqt1 and Tapa1 on mouse chromosome 7F4/F5 corresponding to the Beckwith-Wiedemann syndrome region on human 11p15.5: long-stretches of unusually well conserved intronic sequences of kvlqt1 between mouse and human. Yatsuki H, et al. DNA Res, 2000 Jun 30. PMID 10907850
  5. Kcnq1ot1 noncoding RNA mediates transcriptional gene silencing by interacting with Dnmt1. Mohammad F, et al. Development, 2010 Aug 1. PMID 20573698

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables cysteine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-tRNA ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables tRNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cysteinyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cysteinyl-tRNA aminoacylation ISO
Inferred from Sequence Orthology
more info
  
involved_in tRNA aminoacylation for protein translation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cysteine--tRNA ligase, cytoplasmic
Names
cysRS
cysteinyl-tRNA synthetase, cytoplasmic
NP_001239522.1
NP_038770.3
XP_006508690.1
XP_011240303.1
XP_017177784.1
XP_030098491.1
XP_036009038.1
XP_036009039.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252593.1 → NP_001239522.1  cysteine--tRNA ligase, cytoplasmic isoform 2

    See identical proteins and their annotated locations for NP_001239522.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate, in-frame, exon in the 5' coding region, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AK152866, BC030473, BY021374, BY253195
    Consensus CDS
    CCDS57597.1
    UniProtKB/TrEMBL
    Q3U716, Q3UXN3
    Related
    ENSMUSP00000101529.4, ENSMUST00000105909.4
    Conserved Domains (2) summary
    cd00672
    Location:30 → 445
    CysRS_core; catalytic core domain of cysteinyl tRNA synthetase
    PTZ00399
    Location:1 → 739
    PTZ00399; cysteinyl-tRNA-synthetase; Provisional

  2. NM_013742.5 → NP_038770.3  cysteine--tRNA ligase, cytoplasmic isoform 1

    See identical proteins and their annotated locations for NP_038770.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).
    Source sequence(s)
    AJ276796, AK135433, BC030473, BY021374, BY253195
    Consensus CDS
    CCDS40198.1
    UniProtKB/Swiss-Prot
    O88303, Q8BP81, Q8CAY7, Q8CCE3, Q8K0S4, Q9ER68, Q9ER72
    UniProtKB/TrEMBL
    Q3UXN3
    Related
    ENSMUSP00000010899.8, ENSMUST00000010899.14
    Conserved Domains (3) summary
    cd00672
    Location:113 → 528
    CysRS_core; catalytic core domain of cysteinyl tRNA synthetase
    cd10310
    Location:4 → 76
    GST_C_CysRS_N; Glutathione S-transferase C-terminal-like, alpha helical domain of Cysteinyl-tRNA synthetase from higher eukaryotes
    PTZ00399
    Location:91 → 827
    PTZ00399; cysteinyl-tRNA-synthetase; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    143110967..143153827 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153145.1 → XP_036009038.1  cysteine--tRNA ligase, cytoplasmic isoform X2

    UniProtKB/TrEMBL
    Q3UXN3
    Conserved Domains (2) summary
    cd10310
    Location:4 → 76
    GST_C_CysRS_N; Glutathione S-transferase C-terminal-like, alpha helical domain of Cysteinyl-tRNA synthetase from higher eukaryotes
    PTZ00399
    Location:91 → 720
    PTZ00399; cysteinyl-tRNA-synthetase; Provisional

  2. XM_011242001.2 → XP_011240303.1  cysteine--tRNA ligase, cytoplasmic isoform X4

    See identical proteins and their annotated locations for XP_011240303.1

    Conserved Domains (1) summary
    PTZ00399
    Location:118 → 647
    PTZ00399; cysteinyl-tRNA-synthetase; Provisional

  3. XM_006508627.3 → XP_006508690.1  cysteine--tRNA ligase, cytoplasmic isoform X1

    UniProtKB/TrEMBL
    Q3UXN3
    Conserved Domains (2) summary
    cd10310
    Location:4 → 76
    GST_C_CysRS_N; Glutathione S-transferase C-terminal-like, alpha helical domain of Cysteinyl-tRNA synthetase from higher eukaryotes
    PTZ00399
    Location:91 → 807
    PTZ00399; cysteinyl-tRNA-synthetase; Provisional

  4. XM_030242631.1 → XP_030098491.1  cysteine--tRNA ligase, cytoplasmic isoform X4

    Conserved Domains (1) summary
    PTZ00399
    Location:118 → 647
    PTZ00399; cysteinyl-tRNA-synthetase; Provisional

  5. XM_036153146.1 → XP_036009039.1  cysteine--tRNA ligase, cytoplasmic isoform X5

    Conserved Domains (1) summary
    PTZ00399
    Location:45 → 522
    PTZ00399; cysteinyl-tRNA-synthetase; Provisional

  6. XM_017322295.1 → XP_017177784.1  cysteine--tRNA ligase, cytoplasmic isoform X3

    UniProtKB/TrEMBL
    Q3UXN3
    Conserved Domains (2) summary
    cd10310
    Location:4 → 76
    GST_C_CysRS_N; Glutathione S-transferase C-terminal-like, alpha helical domain of Cysteinyl-tRNA synthetase from higher eukaryotes
    PTZ00399
    Location:91 → 690
    PTZ00399; cysteinyl-tRNA-synthetase; Provisional

RNA

  1. XR_378611.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ER72.2 GenPept UniProtKB/Swiss-Prot:Q9ER72

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