U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Tars3 threonyl-tRNA synthetase 3 [ Mus musculus (house mouse) ]

Gene ID: 272396, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Tars3provided by MGI
Official Full Name
threonyl-tRNA synthetase 3provided by MGI
Primary source
MGI:MGI:2444486
See related
Ensembl:ENSMUSG00000030515 AllianceGenome:MGI:2444486
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tarsl2; A530046H20Rik
Summary
Enables threonine-tRNA ligase activity. Involved in threonyl-tRNA aminoacylation. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; nervous system; respiratory system; sensory organ; and urinary system. Orthologous to human TARS3 (threonyl-tRNA synthetase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14 (RPKM 7.7), liver E14.5 (RPKM 6.6) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
7 C; 7 35.23 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (65294610..65341841)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (65644898..65692093)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene tight junction protein 1 Neighboring gene STARR-seq mESC enhancer starr_19058 Neighboring gene STARR-seq mESC enhancer starr_19059 Neighboring gene STARR-seq mESC enhancer starr_19061 Neighboring gene cDNA sequence BC046251 Neighboring gene STARR-positive B cell enhancer ABC_E1341 Neighboring gene predicted gene, 51484 Neighboring gene predicted gene, 33234 Neighboring gene TM2 domain containing 3 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Loss of threonyl-tRNA synthetase-like protein Tarsl2 has little impact on protein synthesis but affects mouse development. Zeng QY, et al. J Biol Chem, 2023 May. PMID 37059185, Free PMC Article
  2. Newly acquired N-terminal extension targets threonyl-tRNA synthetase-like protein into the multiple tRNA synthetase complex. Zhou XL, et al. Nucleic Acids Res, 2019 Sep 19. PMID 31287872, Free PMC Article
  3. A threonyl-tRNA synthetase-like protein has tRNA aminoacylation and editing activities. Chen Y, et al. Nucleic Acids Res, 2018 Apr 20. PMID 29579307, Free PMC Article
  4. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article
  5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Loss of threonyl-tRNA synthetase-like protein Tarsl2 has little impact on protein synthesis but affects mouse development.
    Title: Loss of threonyl-tRNA synthetase-like protein Tarsl2 has little impact on protein synthesis but affects mouse development.
  2. Newly acquired N-terminal extension targets threonyl-tRNA synthetase-like protein into the multiple tRNA synthetase complex.
    Title: Newly acquired N-terminal extension targets threonyl-tRNA synthetase-like protein into the multiple tRNA synthetase complex.
  3. Our results provided the first analysis of the aminoacylation and editing activities of ThrRS-L, and improved our understanding of Tarsl2.
    Title: A threonyl-tRNA synthetase-like protein has tRNA aminoacylation and editing activities.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC31414

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables threonine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables threonine-tRNA ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA aminoacylation for protein translation IEA
Inferred from Electronic Annotation
more info
  
involved_in threonyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in threonyl-tRNA aminoacylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
threonine--tRNA ligase 2, cytoplasmic
Names
probable threonine--tRNA ligase 2, cytoplasmic
probable threonyl-tRNA synthetase 2, cytoplasmic
thrRS
threonyl-tRNA synthetase protein 3
threonyl-tRNA synthetase-like 2
threonyl-tRNA synthetase-like protein 2
NP_758514.2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172310.2 → NP_758514.2  threonine--tRNA ligase 2, cytoplasmic

    See identical proteins and their annotated locations for NP_758514.2

    Status: VALIDATED

    Source sequence(s)
    AK040927, AV355827, BB642214
    Consensus CDS
    CCDS21339.1
    UniProtKB/Swiss-Prot
    Q8BLY2, Q8CHT2
    Related
    ENSMUSP00000032728.9, ENSMUST00000032728.9
    Conserved Domains (6) summary
    cd01667
    Location:150 → 211
    TGS_ThrRS_N; TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and ...
    PLN02908
    Location:108 → 783
    PLN02908; threonyl-tRNA synthetase
    smart00863
    Location:317 → 364
    tRNA_SAD; Threonyl and Alanyl tRNA synthetase second additional domain
    cd00771
    Location:388 → 685
    ThrRS_core; Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent ...
    cd00860
    Location:685 → 776
    ThrRS_anticodon; ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is ...
    cl23720
    Location:14 → 107
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    65294610..65341841
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_004934116.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BLY2.1 GenPept UniProtKB/Swiss-Prot:Q8BLY2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous