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Lrrc4b leucine rich repeat containing 4B [ Mus musculus (house mouse) ]

Gene ID: 272381, updated on 21-Apr-2024

Summary

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Official Symbol
Lrrc4bprovided by MGI
Official Full Name
leucine rich repeat containing 4Bprovided by MGI
Primary source
MGI:MGI:3027390
See related
Ensembl:ENSMUSG00000047085 AllianceGenome:MGI:3027390
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ngl3; Lrig4; A830007M12
Summary
Enables signaling receptor binding activity. Involved in positive regulation of synapse assembly. Located in cerebellar mossy fiber. Is expressed in several structures, including branchial arch; central nervous system; heart; sensory organ; and sympathetic nervous system. Orthologous to human LRRC4B (leucine rich repeat containing 4B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in whole brain E14.5 (RPKM 96.7), CNS E18 (RPKM 74.6) and 9 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 B3; 7 28.83 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (44091911..44112775)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (44442487..44463351)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700008O03 gene Neighboring gene synaptotagmin III Neighboring gene STARR-positive B cell enhancer ABC_E4924 Neighboring gene STARR-seq mESC enhancer starr_18797 Neighboring gene predicted gene, 39002 Neighboring gene predicted gene, 39003 Neighboring gene STARR-positive B cell enhancer ABC_E9110 Neighboring gene aspartate dehydrogenase domain containing Neighboring gene microRNA 7052 Neighboring gene Josephin domain containing 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. NGL-3-induced presynaptic differentiation of hippocampal neurons in an afadin-dependent, nectin-1-independent manner. Maruo T, et al. Genes Cells, 2017 Aug. PMID 28695613
  2. NGL-3 in the regulation of brain development, Akt/GSK3b signaling, long-term depression, and locomotive and cognitive behaviors. Lee H, et al. PLoS Biol, 2019 Jun. PMID 31166939, Free PMC Article
  3. IL-1 receptor accessory protein-like 1 associated with mental retardation and autism mediates synapse formation by trans-synaptic interaction with protein tyrosine phosphatase δ. Yoshida T, et al. J Neurosci, 2011 Sep 21. PMID 21940441, Free PMC Article
  4. LIG family receptor tyrosine kinase-associated proteins modulate growth factor signals during neural development. Mandai K, et al. Neuron, 2009 Sep 10. PMID 19755105, Free PMC Article
  5. NGL family PSD-95-interacting adhesion molecules regulate excitatory synapse formation. Kim S, et al. Nat Neurosci, 2006 Oct. PMID 16980967

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NGL-3 induced differentiation of hippocampal mossy fibers. This activity of NGL-3 was dependent on afadin, but not the afadin-binding presynaptic nectin-1.
    Title: NGL-3-induced presynaptic differentiation of hippocampal neurons in an afadin-dependent, nectin-1-independent manner.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of synapse assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of synapse assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of postsynaptic density assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of postsynaptic density assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of presynapse assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of presynapse assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in synaptic membrane adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synaptic membrane adhesion ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cerebellar mossy fiber IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in postsynaptic density membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in postsynaptic density membrane ISO
Inferred from Sequence Orthology
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
leucine-rich repeat-containing protein 4B
Names
NGL-3
leucine-rich repeats and immunoglobulin-like domains 4
netrin-G3 ligand

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198250.1 → NP_937893.1  leucine-rich repeat-containing protein 4B precursor

    See identical proteins and their annotated locations for NP_937893.1

    Status: PROVISIONAL

    Source sequence(s)
    BC060263
    Consensus CDS
    CCDS21206.1
    UniProtKB/Swiss-Prot
    P0C192
    Related
    ENSMUSP00000053123.9, ENSMUST00000058667.15
    Conserved Domains (6) summary
    smart00013
    Location:59 → 92
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:313 → 363
    LRRCT; Leucine rich repeat C-terminal domain
    COG4886
    Location:89 → 299
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:90 → 113
    LRR_RI; leucine-rich repeat [structural motif]
    pfam07679
    Location:366 → 455
    I-set; Immunoglobulin I-set domain
    cd00096
    Location:366 → 369
    Ig; Ig strand A [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    44091911..44112775
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0C192.1 GenPept UniProtKB/Swiss-Prot:P0C192

Gene LinkOut

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