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Sgk2 serum/glucocorticoid regulated kinase 2 [ Mus musculus (house mouse) ]

Gene ID: 27219, updated on 11-Apr-2024

Summary

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Official Symbol
Sgk2provided by MGI
Official Full Name
serum/glucocorticoid regulated kinase 2provided by MGI
Primary source
MGI:MGI:1351318
See related
Ensembl:ENSMUSG00000017868 AllianceGenome:MGI:1351318
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sgkl
Summary
Predicted to enable potassium channel regulator activity and protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction and peptidyl-serine phosphorylation. Predicted to act upstream of or within phosphorylation. Predicted to be located in nucleoplasm. Orthologous to human SGK2 (serum/glucocorticoid regulated kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in kidney adult (RPKM 26.4), liver adult (RPKM 9.0) and 7 other tissues See more
Orthologs
human all
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Genomic context

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See Sgk2 in Genome Data Viewer
Location:
2 H2; 2 83.93 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (162829249..162856059)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (162987327..163014139)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene L3MBTL1 histone methyl-lysine binding protein Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene intraflagellar transport 52 Neighboring gene STARR-seq mESC enhancer starr_06293 Neighboring gene STARR-seq mESC enhancer starr_06295 Neighboring gene STARR-positive B cell enhancer ABC_E6013 Neighboring gene myeloblastosis oncogene-like 2 Neighboring gene microRNA 7003

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Protein Kinase SGK2 Is Induced by the β(3) Adrenergic Receptor-cAMP-PKA-PGC-1α/NT-PGC-1α Axis but Dispensable for Brown/Beige Adipose Tissue Thermogenesis. Park CH, et al. Front Physiol, 2021. PMID 34899399, Free PMC Article
  2. Glucose elicits serine/threonine kinase VRK1 to phosphorylate nuclear pregnane X receptor as a novel hepatic gluconeogenic signal. Gotoh S, et al. Cell Signal, 2017 Dec. PMID 28911860
  3. Expression and role of serum and glucocorticoid-regulated kinase 2 in the regulation of Na+/H+ exchanger 3 in the mammalian kidney. Pao AC, et al. Am J Physiol Renal Physiol, 2010 Dec. PMID 20926631, Free PMC Article
  4. A mutation in the serum and glucocorticoid-inducible kinase-like kinase (Sgkl) gene is associated with defective hair growth in mice. Masujin K, et al. DNA Res, 2004 Dec 31. PMID 15871460
  5. Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase. Kobayashi T, et al. Biochem J, 1999 Nov 15. PMID 10548550, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. VRK1 self-represses its activity to phosphorylate PXR through cyclin-dependent kinase 2 (CDK2) in high glucose conditions, resulting in the repression of the PCK1 gene. This PXR phosphorylation was also observed in fasting mouse livers. Thus, the VRK1-CDK2-PXR-PP2Calpha-SGK2 pathway can be a novel physiological cell signaling that regulates gluconeogenesis in response to glucose.
    Title: Glucose elicits serine/threonine kinase VRK1 to phosphorylate nuclear pregnane X receptor as a novel hepatic gluconeogenic signal.
  2. the nucleotide substitution in the Sgkl gene is the causative mutation for defective hair growth in the ypc mutant mouse and the signaling pathway involving SGKL plays an essential role in mammalian hair development
    Title: A mutation in the serum and glucocorticoid-inducible kinase-like kinase (Sgkl) gene is associated with defective hair growth in mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables potassium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables potassium channel regulator activity ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase Sgk2
NP_001278081.1
NP_001278083.1
NP_038759.1
XP_006499721.1
XP_006499723.1
XP_011237882.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291152.1 → NP_001278081.1  serine/threonine-protein kinase Sgk2 isoform b

    See identical proteins and their annotated locations for NP_001278081.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (b) that is 1 aa shorter than isoform a. The 5' UTR of this variant is incomplete due to lack of a complete transcript and splice pattern ambiguity in the upstream region.
    Source sequence(s)
    AK050009, AK136559, AV370098, BB350718
    UniProtKB/TrEMBL
    Q3UW73
    Conserved Domains (2) summary
    smart00220
    Location:35 → 291
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:39 → 358
    PKc_like; Protein Kinases, catalytic domain

  2. NM_001291154.1 → NP_001278083.1  serine/threonine-protein kinase Sgk2 isoform c

    See identical proteins and their annotated locations for NP_001278083.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate in-frame exon in the central coding region, compared to variant 1. The encoded isoform (c) is shorter than isoform a.
    Source sequence(s)
    AI747981, AK050009, AL591584, AV370098, BB350718
    Consensus CDS
    CCDS71184.1
    UniProtKB/TrEMBL
    Q3UW73
    Related
    ENSMUSP00000112468.2, ENSMUST00000117123.2
    Conserved Domains (1) summary
    cl21453
    Location:39 → 330
    PKc_like; Protein Kinases, catalytic domain

  3. NM_013731.3 → NP_038759.1  serine/threonine-protein kinase Sgk2 isoform a

    See identical proteins and their annotated locations for NP_038759.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AI747981, AK050009, AK136559, AV370098, BB350718
    Consensus CDS
    CCDS17004.1
    UniProtKB/Swiss-Prot
    B7ZC31, Q8R0P6, Q9QZS5
    UniProtKB/TrEMBL
    Q3UW73
    Related
    ENSMUSP00000018012.8, ENSMUST00000018012.14
    Conserved Domains (1) summary
    cl21453
    Location:39 → 359
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    162829249..162856059
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006499660.5 → XP_006499723.1  serine/threonine-protein kinase Sgk2 isoform X3

    Conserved Domains (1) summary
    cl21453
    Location:39 → 283
    PKc_like; Protein Kinases, catalytic domain

  2. XM_011239580.3 → XP_011237882.1  serine/threonine-protein kinase Sgk2 isoform X2

    See identical proteins and their annotated locations for XP_011237882.1

    UniProtKB/TrEMBL
    Q3UW73
    Conserved Domains (1) summary
    cl21453
    Location:39 → 330
    PKc_like; Protein Kinases, catalytic domain

  3. XM_006499658.5 → XP_006499721.1  serine/threonine-protein kinase Sgk2 isoform X1

    See identical proteins and their annotated locations for XP_006499721.1

    UniProtKB/Swiss-Prot
    B7ZC31, Q8R0P6, Q9QZS5
    UniProtKB/TrEMBL
    Q3UW73
    Conserved Domains (1) summary
    cl21453
    Location:39 → 359
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QZS5.1 GenPept UniProtKB/Swiss-Prot:Q9QZS5

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