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Azi2 5-azacytidine induced gene 2 [ Mus musculus (house mouse) ]

Gene ID: 27215, updated on 5-Mar-2024

Summary

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Official Symbol
Azi2provided by MGI
Official Full Name
5-azacytidine induced gene 2provided by MGI
Primary source
MGI:MGI:1351332
See related
Ensembl:ENSMUSG00000039285 AllianceGenome:MGI:1351332
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AZ2; Nap1
Summary
Acts upstream of or within several processes, including I-kappaB kinase/NF-kappaB signaling; dendritic cell differentiation; and dendritic cell proliferation. Located in cytoplasm. Is expressed in central nervous system and retina. Orthologous to human AZI2 (5-azacytidine induced 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 8.1), bladder adult (RPKM 7.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 F3; 9 69.86 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (117869510..117898866)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (118040442..118069798)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene RNA binding motif, single stranded interacting protein Neighboring gene predicted gene, 39450 Neighboring gene predicted gene, 26614 Neighboring gene STARR-seq mESC enhancer starr_25450 Neighboring gene predicted gene, 50606 Neighboring gene STARR-positive B cell enhancer ABC_E3864 Neighboring gene STARR-positive B cell enhancer ABC_E2921 Neighboring gene STARR-positive B cell enhancer mm9_chr9:117962449-117962749 Neighboring gene zinc finger, CW type with PWWP domain 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:118059288-118059397 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:118105829-118106030 Neighboring gene C-X9-C motif containing 1 Neighboring gene predicted gene, 17399 Neighboring gene predicted gene, 53195

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. AZI2 positively regulates the induction of type I interferon in influenza-trigger pediatric pneumonia. Wei M, et al. Pathog Dis, 2022 Jul 1. PMID 35595469
  2. Genome-wide association study of behavioral, physiological and gene expression traits in outbred CFW mice. Parker CC, et al. Nat Genet, 2016 Aug. PMID 27376237, Free PMC Article
  3. Isolation of the novel cDNA of a gene of which expression is induced by a demethylating stimulus. Miyagawa J, et al. Gene, 1999 Nov 29. PMID 10580148
  4. Tripartite motif-containing protein 38 negatively regulates TLR3/4- and RIG-I-mediated IFN-β production and antiviral response by targeting NAP1. Zhao W, et al. J Immunol, 2012 Jun 1. PMID 22539786
  5. Brain formation of oestrogen in the mouse: sex dimorphism in aromatase development. Hutchison JB, et al. J Steroid Biochem Mol Biol, 1994 Jun. PMID 8043507

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. AZI2 positively regulates the induction of type I interferon in influenza-trigger pediatric pneumonia.
    Title: AZI2 positively regulates the induction of type I interferon in influenza-trigger pediatric pneumonia.
  2. AZI2 expression is critical for the generation of cDCs by GM-CSF and can potentially be used to increase the efficiency of immunization by cDCs.
    Title: Critical role of AZI2 in GM-CSF-induced dendritic cell differentiation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within T cell activation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within T cell activation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cytokine production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within dendritic cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within dendritic cell proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within interleukin-6 production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of canonical NF-kappaB signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within type II interferon production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
5-azacytidine-induced protein 2
Names
NF-kappa-B-activating kinase-associated protein 1
nak-associated protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001048146.2 → NP_001041611.1  5-azacytidine-induced protein 2 isoform b

    See identical proteins and their annotated locations for NP_001041611.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes a 3' terminal exon that extends past a splice site that is used in variant 1. It encodes isoform b that is shorter and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AC157475, AI390224, AK134714
    Consensus CDS
    CCDS52959.1
    UniProtKB/Swiss-Prot
    Q9QYP6
    Related
    ENSMUSP00000114980.2, ENSMUST00000134433.8
    Conserved Domains (1) summary
    pfam12845
    Location:229 → 267
    TBD; TBD domain

  2. NM_001286507.1 → NP_001273436.1  5-azacytidine-induced protein 2 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in both UTR's and the coding region but maintains the reading frame, compared to variant 1. This results in a protein that has shorter N-terminus and distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AI390224, AK036102
    UniProtKB/Swiss-Prot
    Q9QYP6
    Conserved Domains (1) summary
    pfam12845
    Location:82 → 124
    TBD; TBD domain

  3. NM_001286508.1 → NP_001273437.1  5-azacytidine-induced protein 2 isoform a

    See identical proteins and their annotated locations for NP_001273437.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1 and 4 encode the same protein (isoform a).
    Source sequence(s)
    AC157475, AI390224, AK030076, AV027010
    Consensus CDS
    CCDS40799.1
    UniProtKB/Swiss-Prot
    Q3TIN1, Q3V3R2, Q9CUI5, Q9QYP6
    Related
    ENSMUSP00000118765.2, ENSMUST00000133580.8
    Conserved Domains (1) summary
    pfam12845
    Location:229 → 278
    TBD; TBD domain

  4. NM_001421321.1 → NP_001408250.1  5-azacytidine-induced protein 2 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC157475

  5. NM_013727.4 → NP_038755.1  5-azacytidine-induced protein 2 isoform a

    See identical proteins and their annotated locations for NP_038755.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform a). Variants 1 and 4 encode the same protein.
    Source sequence(s)
    AC157475, AI390224, AK030076, AK153477, AV027010
    Consensus CDS
    CCDS40799.1
    UniProtKB/Swiss-Prot
    Q3TIN1, Q3V3R2, Q9CUI5, Q9QYP6
    Related
    ENSMUSP00000044350.6, ENSMUST00000044454.12
    Conserved Domains (1) summary
    pfam12845
    Location:229 → 278
    TBD; TBD domain

RNA

  1. NR_185293.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC157475

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    117869510..117898866
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155042.1 → XP_036010935.1  5-azacytidine-induced protein 2 isoform X4

    Conserved Domains (2) summary
    COG1196
    Location:46 → 220
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam12845
    Location:227 → 261
    TBD; TBD domain

  2. XM_006512148.3 → XP_006512211.1  5-azacytidine-induced protein 2 isoform X4

    See identical proteins and their annotated locations for XP_006512211.1

    Conserved Domains (2) summary
    COG1196
    Location:46 → 220
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam12845
    Location:227 → 261
    TBD; TBD domain

  3. XM_036155041.1 → XP_036010934.1  5-azacytidine-induced protein 2 isoform X2

    Conserved Domains (2) summary
    COG1196
    Location:46 → 220
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam12845
    Location:227 → 261
    TBD; TBD domain

  4. XM_036155040.1 → XP_036010933.1  5-azacytidine-induced protein 2 isoform X1

    Conserved Domains (2) summary
    COG1196
    Location:46 → 220
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam12845
    Location:227 → 261
    TBD; TBD domain

  5. XM_006512149.3 → XP_006512212.1  5-azacytidine-induced protein 2 isoform X5

    See identical proteins and their annotated locations for XP_006512212.1

    Conserved Domains (1) summary
    pfam12845
    Location:80 → 131
    TBD; TBD domain

RNA

  1. XR_004935444.1 RNA Sequence

  2. XR_004935443.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QYP6.1 GenPept UniProtKB/Swiss-Prot:Q9QYP6

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