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Dbf4 DBF4 zinc finger [ Mus musculus (house mouse) ]

Gene ID: 27214, updated on 5-Mar-2024

Summary

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Official Symbol
Dbf4provided by MGI
Official Full Name
DBF4 zinc fingerprovided by MGI
Primary source
MGI:MGI:1351328
See related
Ensembl:ENSMUSG00000002297 AllianceGenome:MGI:1351328
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
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Summary
Predicted to enable protein serine/threonine kinase activator activity and protein serine/threonine kinase activity. Predicted to be involved in positive regulation of nuclear cell cycle DNA replication and regulation of cell cycle phase transition. Predicted to act upstream of or within traversing start control point of mitotic cell cycle. Located in nucleus. Is expressed in several structures, including brain ventricular layer; early conceptus; genitourinary system; and gut. Orthologous to human DBF4 (DBF4 zinc finger). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 20.9), liver E14 (RPKM 16.1) and 15 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 A1; 5 3.43 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (8446969..8472789, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (8396969..8422725, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene a disintegrin and metallopeptidase domain 22 Neighboring gene STARR-seq mESC enhancer starr_12382 Neighboring gene predicted gene, 23993 Neighboring gene STARR-seq mESC enhancer starr_12383 Neighboring gene STARR-seq mESC enhancer starr_12384 Neighboring gene ribosomal protein L19 pseudogene Neighboring gene STARR-seq mESC enhancer starr_12387 Neighboring gene solute carrier family 25, member 40 Neighboring gene STARR-positive B cell enhancer mm9_chr5:8489752-8490052 Neighboring gene STARR-seq mESC enhancer starr_12390 Neighboring gene RUN domain containing 3B Neighboring gene ATP-binding cassette, sub-family B member 1A Neighboring gene predicted gene, 31157

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cloning and characterization of Chinese hamster homologue of yeast DBF4 (ChDBF4). Guo B, et al. Gene, 2001 Feb 21. PMID 11250080
  2. Identification, characterization and chromosomal localization of the cognate human and murine DBF4 genes. Lepke M, et al. Mol Gen Genet, 1999 Sep. PMID 10517317
  3. Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells. Kneissl M, et al. J Mol Biol, 2003 Mar 14. PMID 12614612
  4. Expression of genes involved in mammalian meiosis during the transition from egg to embryo. Hwang SY, et al. Mol Reprod Dev, 2001 Jun. PMID 11389549
  5. Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program. Sundberg JP, et al. PLoS One, 2017. PMID 28700664, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity ISA
Inferred from Sequence Alignment
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA replication IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of nuclear cell cycle DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell cycle phase transition IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within traversing start control point of mitotic cell cycle ISA
Inferred from Sequence Alignment
more info
 PubMed 
Component Evidence Code Pubs
part_of Dbf4-dependent protein kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
protein DBF4 homolog A
Names
DBF4 homolog
activator of S phase kinase

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001190717.1 → NP_001177646.1  protein DBF4 homolog A isoform 2

    See identical proteins and their annotated locations for NP_001177646.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC152165, AK132403, BB611145
    Consensus CDS
    CCDS57324.1
    UniProtKB/Swiss-Prot
    Q9QZ41
    Related
    ENSMUSP00000002368.10, ENSMUST00000002368.16
    Conserved Domains (2) summary
    cd00027
    Location:48 → 92
    BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
    cl02684
    Location:287 → 334
    zf-DBF; DBF zinc finger

  2. NM_013726.3 → NP_038754.1  protein DBF4 homolog A isoform 1

    See identical proteins and their annotated locations for NP_038754.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC152165, AK132403, BB611145, BC138709
    Consensus CDS
    CCDS19081.1
    UniProtKB/Swiss-Prot
    B7ZNS0, Q3TQP4, Q3V1K2, Q6NSQ1, Q9CXF2, Q9QZ41
    UniProtKB/TrEMBL
    B2RS44
    Related
    ENSMUSP00000132906.2, ENSMUST00000171808.8
    Conserved Domains (2) summary
    cd00027
    Location:48 → 92
    BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
    cl02684
    Location:288 → 335
    zf-DBF; DBF zinc finger

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    8446969..8472789 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_003955657.2 RNA Sequence

  2. XR_003955658.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QZ41.1 GenPept UniProtKB/Swiss-Prot:Q9QZ41

Gene LinkOut

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