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Nrk Nik related kinase [ Mus musculus (house mouse) ]

Gene ID: 27206, updated on 5-Mar-2024

Summary

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Official Symbol
Nrkprovided by MGI
Official Full Name
Nik related kinaseprovided by MGI
Primary source
MGI:MGI:1351326
See related
Ensembl:ENSMUSG00000052854 AllianceGenome:MGI:1351326
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nesk
Summary
Enables protein kinase activity. Acts upstream of or within several processes, including parturition; positive regulation of JNK cascade; and regulation of spongiotrophoblast cell proliferation. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; limb; and musculature. Orthologous to human NRK (Nik related kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in placenta adult (RPKM 93.3) and limb E14.5 (RPKM 16.7) See more
Orthologs
human all
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Genomic context

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Location:
X F1; X 61.15 cM
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (137814980..137911281)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (138914231..139010532)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene interleukin 1 receptor accessory protein-like 2 Neighboring gene STARR-seq mESC enhancer starr_47984 Neighboring gene STARR-seq mESC enhancer starr_47985 Neighboring gene STARR-seq mESC enhancer starr_47986 Neighboring gene zinc finger protein 259 pseudogene Neighboring gene STARR-seq mESC enhancer starr_47988 Neighboring gene zinc finger CCCH type containing 14 pseudogene Neighboring gene RIKEN cDNA 4930513O06 gene Neighboring gene STARR-seq mESC enhancer starr_47989 Neighboring gene serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Proteomic analysis of Nrk gene-disrupted placental tissue cells explains physiological significance of NRK. Denda K, et al. BMC Res Notes, 2019 Nov 29. PMID 31783915, Free PMC Article
  2. Nik-related kinase regulates trophoblast proliferation and placental development by modulating AKT phosphorylation. Morioka Y, et al. PLoS One, 2017. PMID 28152035, Free PMC Article
  3. Deficiency of X-Linked Protein Kinase Nrk during Pregnancy Triggers Breast Tumor in Mice. Yanagawa T, et al. Am J Pathol, 2016 Oct. PMID 27634343
  4. NESK, a member of the germinal center kinase family that activates the c-Jun N-terminal kinase pathway and is expressed during the late stages of embryogenesis. Nakano K, et al. J Biol Chem, 2000 Jul 7. PMID 10801798
  5. Nrk: a murine X-linked NIK (Nck-interacting kinase)-related kinase gene expressed in skeletal muscle. Kanai-Azuma M, et al. Mech Dev, 1999 Dec. PMID 10559491

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. protein expression profiles were analyzed in the Nrk-null placenta.
    Title: Proteomic analysis of Nrk gene-disrupted placental tissue cells explains physiological significance of NRK.
  2. The results suggest that Nrk suppresses the excessive proliferation of mammary epithelial cells during pregnancy, and the impairment of this regulatory system leads to frequent occurrence of breast tumor in Nrk mutant mice.
    Title: Deficiency of X-Linked Protein Kinase Nrk during Pregnancy Triggers Breast Tumor in Mice.
  3. regulates trophoblast proliferation and placental development by modulating AKT phosphorylation
    Title: Nik-related kinase regulates trophoblast proliferation and placental development by modulating AKT phosphorylation.
  4. Nrk, an X-linked protein kinase in the germinal center kinase family, is required for placental development and fetoplacental induction of labor.
    Title: Nrk, an X-linked protein kinase in the germinal center kinase family, is required for placental development and fetoplacental induction of labor.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein kinase activity ISA
Inferred from Sequence Alignment
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within parturition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of JNK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of JNK cascade IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of spongiotrophoblast cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
nik-related protein kinase
Names
NIK-like embryo-specific kinase
nck-interacting kinase-like embryo specific kinase
NP_038752.2
XP_006528613.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013724.2 → NP_038752.2  nik-related protein kinase

    See identical proteins and their annotated locations for NP_038752.2

    Status: VALIDATED

    Source sequence(s)
    BX324117, BX784027
    Consensus CDS
    CCDS41143.1
    UniProtKB/Swiss-Prot
    B2RSW5, Q6NV55, Q8C9S9, Q9R0G8, Q9R0S4
    UniProtKB/TrEMBL
    B1B0C9
    Related
    ENSMUSP00000063397.8, ENSMUST00000064937.14
    Conserved Domains (3) summary
    smart00220
    Location:25 → 313
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl02434
    Location:1143 → 1422
    CNH; CNH domain
    cl21453
    Location:14 → 313
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    137814980..137911281
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006528550.4 → XP_006528613.1  nik-related protein kinase isoform X1

    UniProtKB/TrEMBL
    B1B0C9
    Related
    ENSMUSP00000115962.2, ENSMUST00000131829.2
    Conserved Domains (3) summary
    PRK10811
    Location:430 → 578
    rne; ribonuclease E; Reviewed
    cl02434
    Location:1143 → 1479
    CNH; CNH domain
    cl21453
    Location:14 → 313
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9R0G8.2 GenPept UniProtKB/Swiss-Prot:Q9R0G8

Gene LinkOut

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