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OXGR1 oxoglutarate receptor 1 [ Homo sapiens (human) ]

Gene ID: 27199, updated on 5-Mar-2024

Summary

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Official Symbol
OXGR1provided by HGNC
Official Full Name
oxoglutarate receptor 1provided by HGNC
Primary source
HGNC:HGNC:4531
See related
Ensembl:ENSG00000165621 MIM:606922; AllianceGenome:HGNC:4531
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
aKGR; CAON2; GPR80; GPR99; P2Y15; P2RY15
Summary
This gene encodes a G protein-coupled receptor (GPCR) that belongs to the oxoglutarate receptor family within the GPCR superfamily. The encoded protein is activated by the citric acid intermediate, oxoglutarate, as well as several cysteinyl leukotrienes, including leukotrienes E4, C4 and D4, which are implicated in many inflammatory disorders. In mice, a knock-out of this gene leads to middle ear inflammation, changes in the mucosal epithelium, and an increase in fluid behind the eardrum, and is associated with hearing loss. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016]
Expression
Broad expression in kidney (RPKM 1.0), colon (RPKM 0.6) and 14 other tissues See more
Orthologs
mouse all
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Genomic context

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See OXGR1 in Genome Data Viewer
Location:
13q32.1
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (96985713..96994730, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (96189803..96198827, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (97637967..97646984, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 359 Neighboring gene TUB like protein 3 pseudogene 1 Neighboring gene RN7SK pseudogene 7 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7884 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7885 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7886 Neighboring gene small nucleolar RNA U13 Neighboring gene uncharacterized LOC124903196

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. OXGR1 is a candidate disease gene for human calcium oxalate nephrolithiasis. Majmundar AJ, et al. Genet Med, 2023 Mar. PMID 36571463, Free PMC Article
  2. Expression and localization of GPR99 in human nasal mucosa. Shirasaki H, et al. Auris Nasus Larynx, 2017 Apr. PMID 27324180
  3. The fate of P2Y-related orphan receptors: GPR80/99 and GPR91 are receptors of dicarboxylic acids. Gonzalez NS, et al. Purinergic Signal, 2004 Dec. PMID 18404396, Free PMC Article
  4. The recently deorphanized GPR80 (GPR99) proposed to be the P2Y15 receptor is not a genuine P2Y receptor. Abbracchio MP, et al. Trends Pharmacol Sci, 2005 Jan. PMID 15629198, Free PMC Article
  5. GPR99, a new G protein-coupled receptor with homology to a new subgroup of nucleotide receptors. Wittenberger T, et al. BMC Genomics, 2002 Jul 5. PMID 12098360, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. OXGR1 is a candidate disease gene for human calcium oxalate nephrolithiasis.
    Title: OXGR1 is a candidate disease gene for human calcium oxalate nephrolithiasis.
  2. Changes in expression of orphan receptors GPR99 and GPR107 during the development and establishment of hypertension in spontaneously hypertensive rats.
    Title: Changes in expression of orphan receptors GPR99 and GPR107 during the development and establishment of hypertension in spontaneously hypertensive rats.
  3. Exercise-induced alpha-ketoglutaric acid stimulates muscle hypertrophy and fat loss through OXGR1-dependent adrenal activation.
    Title: Exercise-induced α-ketoglutaric acid stimulates muscle hypertrophy and fat loss through OXGR1-dependent adrenal activation.
  4. GPR99 was mostly expressed in vascular smooth muscle cells of the nasal mucosa. There was no difference in GPR99 protein levels between allergic and non-allergic nasal mucosa.
    Title: Expression and localization of GPR99 in human nasal mucosa.
  5. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  6. Down-Regulation of OXGR1 through DNA Methylation is associated with hepatocellular carcinoma.
    Title: Aberrant DNA methylation profile and frequent methylation of KLK10 and OXGR1 genes in hepatocellular carcinoma.
  7. P2Y15 is a cell surface receptor for AMP and adenosine
    Title: Identification and characterization of a cell-surface receptor, P2Y15, for AMP and adenosine.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Nephrolithiasis, calcium oxalate, 2, with or without nephrocalcinosis
MedGen: C5830516 OMIM: 620374 GeneReviews: Not available
not available

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC119206, MGC119207, MGC119208

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane TAS
Traceable Author Statement
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  
located_in plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
2-oxoglutarate receptor 1
Names
G protein-coupled receptor 80
G-protein coupled receptor 99
P2Y purinoceptor 15
P2Y-like GPCR
P2Y-like nucleotide receptor
alpha-ketoglutarate receptor 1
oxoglutarate (alpha-ketoglutarate) receptor 1
seven transmembrane helix receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001346194.2 → NP_001333123.1  2-oxoglutarate receptor 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3, 4, and 5 encode the same protein.
    Source sequence(s)
    AK122639, AL356486, DN993601
    Consensus CDS
    CCDS9482.1
    UniProtKB/Swiss-Prot
    Q5T5A7, Q86TL1, Q96P68
    UniProtKB/TrEMBL
    B2R986
    Related
    ENSP00000437356.2, ENST00000541038.2
    Conserved Domains (1) summary
    cd15375
    Location:34 → 313
    7tmA_OXGR1; 2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. NM_001346195.2 → NP_001333124.1  2-oxoglutarate receptor 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4, and 5 encode the same protein.
    Source sequence(s)
    AK122639, AL356486, DB204461
    Consensus CDS
    CCDS9482.1
    UniProtKB/Swiss-Prot
    Q5T5A7, Q86TL1, Q96P68
    UniProtKB/TrEMBL
    B2R986
    Conserved Domains (1) summary
    cd15375
    Location:34 → 313
    7tmA_OXGR1; 2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors

  3. NM_001346196.2 → NP_001333125.1  2-oxoglutarate receptor 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4, and 5 encode the same protein.
    Source sequence(s)
    AK122639, AK313684, AL356486, DN993601
    Consensus CDS
    CCDS9482.1
    UniProtKB/Swiss-Prot
    Q5T5A7, Q86TL1, Q96P68
    UniProtKB/TrEMBL
    B2R986
    Related
    ENSP00000438800.1, ENST00000543457.6
    Conserved Domains (1) summary
    cd15375
    Location:34 → 313
    7tmA_OXGR1; 2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors

  4. NM_001346197.2 → NP_001333126.1  2-oxoglutarate receptor 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains an alternate exon and uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4, and 5 encode the same protein.
    Source sequence(s)
    AK122639, AK313684, AL356486, DB204461
    Consensus CDS
    CCDS9482.1
    UniProtKB/Swiss-Prot
    Q5T5A7, Q86TL1, Q96P68
    UniProtKB/TrEMBL
    B2R986
    Related
    ENSP00000445269.2, ENST00000541518.6
    Conserved Domains (1) summary
    cd15375
    Location:34 → 313
    7tmA_OXGR1; 2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors

  5. NM_080818.5 → NP_543008.3  2-oxoglutarate receptor 1

    See identical proteins and their annotated locations for NP_543008.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4, and 5 encode the same protein.
    Source sequence(s)
    AK122639, AL356486, DN993601
    Consensus CDS
    CCDS9482.1
    UniProtKB/Swiss-Prot
    Q5T5A7, Q86TL1, Q96P68
    UniProtKB/TrEMBL
    B2R986
    Related
    ENSP00000298440.1, ENST00000298440.5
    Conserved Domains (1) summary
    cd15375
    Location:34 → 313
    7tmA_OXGR1; 2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    96985713..96994730 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047430274.1 → XP_047286230.1  2-oxoglutarate receptor 1 isoform X1

    UniProtKB/Swiss-Prot
    Q5T5A7, Q86TL1, Q96P68
    UniProtKB/TrEMBL
    B2R986

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    96189803..96198827 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054374465.1 → XP_054230440.1  2-oxoglutarate receptor 1 isoform X1

    UniProtKB/Swiss-Prot
    Q5T5A7, Q86TL1, Q96P68
    UniProtKB/TrEMBL
    B2R986

  2. XM_054374464.1 → XP_054230439.1  2-oxoglutarate receptor 1 isoform X1

    UniProtKB/Swiss-Prot
    Q5T5A7, Q86TL1, Q96P68
    UniProtKB/TrEMBL
    B2R986
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96P68.1 GenPept UniProtKB/Swiss-Prot:Q96P68

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