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SIGLEC9 sialic acid binding Ig like lectin 9 [ Homo sapiens (human) ]

Gene ID: 27180, updated on 22-Apr-2024

Summary

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Official Symbol
SIGLEC9provided by HGNC
Official Full Name
sialic acid binding Ig like lectin 9provided by HGNC
Primary source
HGNC:HGNC:10878
See related
Ensembl:ENSG00000129450 MIM:605640; AllianceGenome:HGNC:10878
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD329; CDw329; FOAP-9; siglec-9; OBBP-LIKE
Summary
Predicted to enable monosaccharide binding activity and sialic acid binding activity. Predicted to be involved in cell adhesion. Predicted to act upstream of or within negative regulation of inflammatory response and negative regulation of phagocytosis, engulfment. Predicted to be located in external side of plasma membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in appendix (RPKM 3.6), spleen (RPKM 2.9) and 15 other tissues See more
Orthologs
all
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Genomic context

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Location:
19q13.41
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (51119778..51136263)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (54211244..54230912)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (51628137..51639520)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 1105 Neighboring gene kallikrein related peptidase 14 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15008 Neighboring gene cytosolic thiouridylase subunit 1 Neighboring gene sialic acid binding Ig like lectin 18, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15009 Neighboring gene uncharacterized LOC124904749 Neighboring gene sialic acid binding Ig like lectin 7 Neighboring gene uncharacterized LOC101928517

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Siglec-9 Restrains Antibody-Dependent Natural Killer Cell Cytotoxicity against SARS-CoV-2. Saini P, et al. mBio, 2023 Feb 28. PMID 36728420, Free PMC Article
  2. Identification and validation of a siglec-based and aging-related 9-gene signature for predicting prognosis in acute myeloid leukemia patients. Shi H, et al. BMC Bioinformatics, 2022 Jul 19. PMID 35854240, Free PMC Article
  3. Modulation of immune cell reactivity with cis-binding Siglec agonists. Delaveris CS, et al. Proc Natl Acad Sci U S A, 2021 Jan 19. PMID 33431669, Free PMC Article
  4. Decreased erythrocyte binding of Siglec-9 increases neutrophil activation in sickle cell disease. Kiser ZM, et al. Blood Cells Mol Dis, 2020 Mar. PMID 31901888, Free PMC Article
  5. Siglec-9 Regulates an Effector Memory CD8(+) T-cell Subset That Congregates in the Melanoma Tumor Microenvironment. Haas Q, et al. Cancer Immunol Res, 2019 May. PMID 30988027

See all (57) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The receptor binding domain of SARS-CoV-2 Omicron subvariants targets Siglec-9 to decrease its immunogenicity by preventing macrophage phagocytosis.
    Title: The receptor binding domain of SARS-CoV-2 Omicron subvariants targets Siglec-9 to decrease its immunogenicity by preventing macrophage phagocytosis.
  2. Expression of Siglec-9 in peripheral blood neutrophils was increased and associated with disease severity in patients with AECOPD.
    Title: Expression of Siglec-9 in peripheral blood neutrophils was increased and associated with disease severity in patients with AECOPD.
  3. The change of Siglec-9 expression in peripheral blood NK cells of SFTS patients can affect the function of NK cells.
    Title: The change of Siglec-9 expression in peripheral blood NK cells of SFTS patients can affect the function of NK cells.
  4. Siglec-9 acts as an immune-checkpoint molecule on macrophages in glioblastoma, restricting T-cell priming and immunotherapy response.
    Title: Siglec-9 acts as an immune-checkpoint molecule on macrophages in glioblastoma, restricting T-cell priming and immunotherapy response.
  5. LINC01004-SPI1 axis-activated SIGLEC9 in tumor-associated macrophages induces radioresistance and the formation of immunosuppressive tumor microenvironment in esophageal squamous cell carcinoma.
    Title: LINC01004-SPI1 axis-activated SIGLEC9 in tumor-associated macrophages induces radioresistance and the formation of immunosuppressive tumor microenvironment in esophageal squamous cell carcinoma.
  6. Siglec-9 Restrains Antibody-Dependent Natural Killer Cell Cytotoxicity against SARS-CoV-2.
    Title: Siglec-9 Restrains Antibody-Dependent Natural Killer Cell Cytotoxicity against SARS-CoV-2.
  7. Identification and validation of a siglec-based and aging-related 9-gene signature for predicting prognosis in acute myeloid leukemia patients.
    Title: Identification and validation of a siglec-based and aging-related 9-gene signature for predicting prognosis in acute myeloid leukemia patients.
  8. Modulation of immune cell reactivity with cis-binding Siglec agonists.
    Title: Modulation of immune cell reactivity with cis-binding Siglec agonists.
  9. The Roles of Siglec7 and Siglec9 on Natural Killer Cells in Virus Infection and Tumour Progression.
    Title: The Roles of Siglec7 and Siglec9 on Natural Killer Cells in Virus Infection and Tumour Progression.
  10. Targeting glycosylated antigens on cancer cells using siglec-7/9-based CAR T-cells.
    Title: Targeting glycosylated antigens on cancer cells using siglec-7/9-based CAR T-cells.
Submit: New GeneRIF Correction See all GeneRIFs (44)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables carbohydrate binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sialic acid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell surface receptor signaling pathway NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in secretory granule membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
sialic acid-binding Ig-like lectin 9
Names
protein FOAP-9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001198558.1 → NP_001185487.1  sialic acid-binding Ig-like lectin 9 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001185487.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK297043, BP305376
    Consensus CDS
    CCDS56100.1
    UniProtKB/Swiss-Prot
    Q9Y336
    Related
    ENSP00000413861.2, ENST00000440804.7
    Conserved Domains (3) summary
    cd05712
    Location:23 → 140
    Ig_Siglec_N; Immunoglobulin (Ig) domain at the N terminus of Siglec (sialic acid-binding Ig-like lectins)
    smart00410
    Location:258 → 336
    IG_like; Immunoglobulin like
    cl11960
    Location:151 → 222
    Ig; Immunoglobulin domain

  2. NM_014441.3 → NP_055256.1  sialic acid-binding Ig-like lectin 9 isoform 2 precursor

    See identical proteins and their annotated locations for NP_055256.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes an alternate 3' terminal coding exon, compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC011473
    Consensus CDS
    CCDS12825.1
    UniProtKB/Swiss-Prot
    Q6GTU4, Q9BYI9, Q9Y336
    Related
    ENSP00000250360.2, ENST00000250360.8
    Conserved Domains (3) summary
    cd05712
    Location:23 → 140
    Ig_Siglec_N; Immunoglobulin (Ig) domain at the N terminus of Siglec (sialic acid-binding Ig-like lectins)
    smart00410
    Location:258 → 336
    IG_like; Immunoglobulin like
    cl11960
    Location:151 → 222
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    51119778..51136263
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047438615.1 → XP_047294571.1  sialic acid-binding Ig-like lectin 9 isoform X2

    UniProtKB/Swiss-Prot
    Q6GTU4, Q9BYI9, Q9Y336

  2. XM_047438616.1 → XP_047294572.1  sialic acid-binding Ig-like lectin 9 isoform X2

    UniProtKB/Swiss-Prot
    Q6GTU4, Q9BYI9, Q9Y336

  3. XM_011526732.4 → XP_011525034.1  sialic acid-binding Ig-like lectin 9 isoform X1

    Conserved Domains (3) summary
    cd05712
    Location:23 → 140
    Ig_Siglec_N; Immunoglobulin (Ig) domain at the N terminus of Siglec (sialic acid-binding Ig-like lectins)
    smart00410
    Location:258 → 336
    IG_like; Immunoglobulin like
    cl11960
    Location:151 → 222
    Ig; Immunoglobulin domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    54211244..54230912
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054320566.1 → XP_054176541.1  sialic acid-binding Ig-like lectin 9 isoform X2

    UniProtKB/Swiss-Prot
    Q6GTU4, Q9BYI9, Q9Y336

  2. XM_054320565.1 → XP_054176540.1  sialic acid-binding Ig-like lectin 9 isoform X1

  3. XM_054320567.1 → XP_054176542.1  sialic acid-binding Ig-like lectin 9 isoform X4

  4. XM_054320564.1 → XP_054176539.1  sialic acid-binding Ig-like lectin 9 isoform X3

  5. XM_054320568.1 → XP_054176543.1  sialic acid-binding Ig-like lectin 9 isoform X5

  6. XM_054320569.1 → XP_054176544.1  sialic acid-binding Ig-like lectin 9 isoform X6

  7. XM_054320570.1 → XP_054176545.1  sialic acid-binding Ig-like lectin 9 isoform X7

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y336.2 GenPept UniProtKB/Swiss-Prot:Q9Y336

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