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Galnt13 polypeptide N-acetylgalactosaminyltransferase 13 [ Mus musculus (house mouse) ]

Gene ID: 271786, updated on 21-Apr-2024

Summary

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Official Symbol
Galnt13provided by MGI
Official Full Name
polypeptide N-acetylgalactosaminyltransferase 13provided by MGI
Primary source
MGI:MGI:2139447
See related
Ensembl:ENSMUSG00000060988 AllianceGenome:MGI:2139447
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A230002A12; A230020F20
Summary
Enables polypeptide N-acetylgalactosaminyltransferase activity. Acts upstream of or within protein O-linked glycosylation. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus. Is expressed in heart; liver; lung; metanephros; and nervous system. Orthologous to human GALNT13 (polypeptide N-acetylgalactosaminyltransferase 13). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 5.4), frontal lobe adult (RPKM 1.6) and 4 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 C1.1; 2 30.77 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (54326217..55008321)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (54436211..55118309)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_04511 Neighboring gene STARR-seq mESC enhancer starr_04512 Neighboring gene predicted gene 14035 Neighboring gene ribosomal protein S9 pseudogene Neighboring gene predicted gene, 24549 Neighboring gene STARR-seq mESC enhancer starr_04513 Neighboring gene STARR-seq mESC enhancer starr_04514 Neighboring gene STARR-seq mESC enhancer starr_04516 Neighboring gene predicted gene, 25489 Neighboring gene STARR-seq mESC enhancer starr_04517 Neighboring gene STARR-seq mESC enhancer starr_04518 Neighboring gene STARR-positive B cell enhancer mm9_chr2:55104656-55104956 Neighboring gene cathepsin B pseudogene Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. pp-GalNAc-T13 induces high metastatic potential of murine Lewis lung cancer by generating trimeric Tn antigen. Matsumoto Y, et al. Biochem Biophys Res Commun, 2012 Mar 2. PMID 22306014
  2. T-cell-specific deletion of a polypeptide N-acetylgalactosaminyl-transferase gene by site-directed recombination. Hennet T, et al. Proc Natl Acad Sci U S A, 1995 Dec 19. PMID 8618846, Free PMC Article
  3. Polypeptide N-Acetylgalactosaminyltransferase 13 Contributes to Neurogenesis via Stabilizing the Mucin-type O-Glycoprotein Podoplanin. Xu Y, et al. J Biol Chem, 2016 Nov 4. PMID 27629416, Free PMC Article
  4. Trimeric Tn antigen on syndecan 1 produced by ppGalNAc-T13 enhances cancer metastasis via a complex formation with integrin α5β1 and matrix metalloproteinase 9. Matsumoto Y, et al. J Biol Chem, 2013 Aug 16. PMID 23814067, Free PMC Article
  5. Expression of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase isoforms in murine tissues determined by real-time PCR: a new view of a large family. Young WW Jr, et al. Glycobiology, 2003 Jul. PMID 12651884

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This study suggests that ppGalNAc-T13 contributes to neuronal differentiation through glycosylating and stabilizing PDPN, which provides insights into the regulatory roles of O-glycosylation in mammalian neural development.
    Title: Polypeptide N-Acetylgalactosaminyltransferase 13 Contributes to Neurogenesis via Stabilizing the Mucin-type O-Glycoprotein Podoplanin.
  2. high expression of the ppGalNAc-T13 gene generates tTn antigen on Syndecan 1, leading to enhanced invasion and metastasis via the formation of a complex consisting of integrin alpha5beta1, Syndecan 1, and MMP-9 in the glycolipid-enriched microdomain/rafts.
    Title: Trimeric Tn antigen on syndecan 1 produced by ppGalNAc-T13 enhances cancer metastasis via a complex formation with integrin α5β1 and matrix metalloproteinase 9.
  3. These data suggested that high expression of pp-GalNAc-T13 gene generated trimeric Tn antigen on Syndecan-1, leading to the enhanced metastasis.
    Title: pp-GalNAc-T13 induces high metastatic potential of murine Lewis lung cancer by generating trimeric Tn antigen.
  4. cloning and characterization of pp-GalNAc-T13; expressed in all neuroblastoma cells examined and primary cultured neurons but not in glioblastoma cells and primary cultured astrocytes
    Title: Cloning and characterization of a new human UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase, designated pp-GalNAc-T13, that is specifically expressed in neurons and synthesizes GalNAc alpha-serine/threonine antigen.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (3) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables polypeptide N-acetylgalactosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables polypeptide N-acetylgalactosaminyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables polypeptide N-acetylgalactosaminyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein O-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein O-linked glycosylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein O-linked glycosylation via serine ISO
Inferred from Sequence Orthology
more info
  
involved_in protein O-linked glycosylation via threonine ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
polypeptide N-acetylgalactosaminyltransferase 13
Names
UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 13
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13
galNAc-T13
polypeptide GalNAc transferase 13
pp-GaNTase 13
pp-GalNAc-T13
protein-UDP acetylgalactosaminyltransferase 13
NP_766618.2
XP_006498150.1
XP_006498154.1
XP_006498155.1
XP_006498156.1
XP_036018146.1
XP_036018147.1
XP_036018148.1
XP_036018149.1
XP_036018150.1
XP_036018151.1
XP_036018152.1
XP_036018153.1
XP_036018154.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173030.2 → NP_766618.2  polypeptide N-acetylgalactosaminyltransferase 13

    See identical proteins and their annotated locations for NP_766618.2

    Status: VALIDATED

    Source sequence(s)
    AK038387, AK038492, AL844895
    Consensus CDS
    CCDS16041.1
    UniProtKB/Swiss-Prot
    Q8BLE4, Q8BYT3, Q8CF93
    UniProtKB/TrEMBL
    A2RRI8
    Related
    ENSMUSP00000108254.2, ENSMUST00000112635.8
    Conserved Domains (2) summary
    cd02510
    Location:118 → 418
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    pfam00652
    Location:431 → 547
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    54326217..55008321
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498091.4 → XP_006498154.1  polypeptide N-acetylgalactosaminyltransferase 13 isoform X4

    See identical proteins and their annotated locations for XP_006498154.1

    UniProtKB/Swiss-Prot
    Q8BLE4, Q8BYT3, Q8CF93
    UniProtKB/TrEMBL
    A2RRI8
    Related
    ENSMUSP00000108255.2, ENSMUST00000112636.8
    Conserved Domains (2) summary
    cd02510
    Location:118 → 418
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    pfam00652
    Location:431 → 547
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

  2. XM_036162258.1 → XP_036018151.1  polypeptide N-acetylgalactosaminyltransferase 13 isoform X3

    Conserved Domains (2) summary
    cd02510
    Location:118 → 418
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    pfam00652
    Location:431 → 548
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

  3. XM_036162257.1 → XP_036018150.1  polypeptide N-acetylgalactosaminyltransferase 13 isoform X3

    Conserved Domains (2) summary
    cd02510
    Location:118 → 418
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    pfam00652
    Location:431 → 548
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

  4. XM_006498092.3 → XP_006498155.1  polypeptide N-acetylgalactosaminyltransferase 13 isoform X4

    See identical proteins and their annotated locations for XP_006498155.1

    UniProtKB/Swiss-Prot
    Q8BLE4, Q8BYT3, Q8CF93
    UniProtKB/TrEMBL
    A2RRI8
    Related
    ENSMUSP00000063464.6, ENSMUST00000068595.6
    Conserved Domains (2) summary
    cd02510
    Location:118 → 418
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    pfam00652
    Location:431 → 547
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

  5. XM_036162260.1 → XP_036018153.1  polypeptide N-acetylgalactosaminyltransferase 13 isoform X3

    Conserved Domains (2) summary
    cd02510
    Location:118 → 418
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    pfam00652
    Location:431 → 548
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

  6. XM_036162261.1 → XP_036018154.1  polypeptide N-acetylgalactosaminyltransferase 13 isoform X4

    UniProtKB/Swiss-Prot
    Q8BLE4, Q8BYT3, Q8CF93
    UniProtKB/TrEMBL
    A2RRI8
    Related
    ENSMUSP00000108253.2, ENSMUST00000112634.8
    Conserved Domains (2) summary
    cd02510
    Location:118 → 418
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    pfam00652
    Location:431 → 547
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

  7. XM_006498087.4 → XP_006498150.1  polypeptide N-acetylgalactosaminyltransferase 13 isoform X2

    See identical proteins and their annotated locations for XP_006498150.1

    Conserved Domains (2) summary
    cd02510
    Location:160 → 460
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    pfam00652
    Location:473 → 589
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

  8. XM_036162253.1 → XP_036018146.1  polypeptide N-acetylgalactosaminyltransferase 13 isoform X1

    Conserved Domains (2) summary
    cd02510
    Location:160 → 460
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    pfam00652
    Location:473 → 590
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

  9. XM_036162254.1 → XP_036018147.1  polypeptide N-acetylgalactosaminyltransferase 13 isoform X1

    Conserved Domains (2) summary
    cd02510
    Location:160 → 460
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    pfam00652
    Location:473 → 590
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

  10. XM_006498093.5 → XP_006498156.1  polypeptide N-acetylgalactosaminyltransferase 13 isoform X5

    Conserved Domains (1) summary
    cd02510
    Location:160 → 429
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans

  11. XM_036162255.1 → XP_036018148.1  polypeptide N-acetylgalactosaminyltransferase 13 isoform X1

    Conserved Domains (2) summary
    cd02510
    Location:160 → 460
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    pfam00652
    Location:473 → 590
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

  12. XM_036162259.1 → XP_036018152.1  polypeptide N-acetylgalactosaminyltransferase 13 isoform X3

    Conserved Domains (2) summary
    cd02510
    Location:118 → 418
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    pfam00652
    Location:431 → 548
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

  13. XM_036162256.1 → XP_036018149.1  polypeptide N-acetylgalactosaminyltransferase 13 isoform X1

    Conserved Domains (2) summary
    cd02510
    Location:160 → 460
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    pfam00652
    Location:473 → 590
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

RNA

  1. XR_374098.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CF93.1 GenPept UniProtKB/Swiss-Prot:Q8CF93

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