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TUBG2 tubulin gamma 2 [ Homo sapiens (human) ]

Gene ID: 27175, updated on 5-Mar-2024

Summary

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Official Symbol
TUBG2provided by HGNC
Official Full Name
tubulin gamma 2provided by HGNC
Primary source
HGNC:HGNC:12419
See related
Ensembl:ENSG00000037042 MIM:605785; AllianceGenome:HGNC:12419
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable GTP binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in microtubule cytoskeleton organization and mitotic sister chromatid segregation. Located in microtubule. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in brain (RPKM 19.4), testis (RPKM 16.1) and 25 other tissues See more
Orthologs
all
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Genomic context

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See TUBG2 in Genome Data Viewer
Location:
17q21.2
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (42659284..42667006)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (43516421..43524145)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (40811302..40819024)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ATP synthase membrane subunit g pseudogene 7 Neighboring gene high mobility group box 3 pseudogene 27 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:40811134-40811901 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:40820248-40820823 Neighboring gene pleckstrin homology, MyTH4 and FERM domain containing H3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12216 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:40825209-40826082 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8540 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8541 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8542 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8543 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12217 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12218 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:40829663-40830164 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:40830165-40830664 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:40831166-40832014 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:40832015-40832863 Neighboring gene Sharpr-MPRA regulatory region 12568 Neighboring gene C-C motif chemokine receptor 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Differential expression of human γ-tubulin isotypes during neuronal development and oxidative stress points to a γ-tubulin-2 prosurvival function. Dráberová E, et al. FASEB J, 2017 May. PMID 28119396
  2. Overexpression of γ-tubulin in non-small cell lung cancer. Maounis NF, et al. Histol Histopathol, 2012 Sep. PMID 22806905
  3. γ-Tubulin 2 nucleates microtubules and is downregulated in mouse early embryogenesis. Vinopal S, et al. PLoS One, 2012. PMID 22235350, Free PMC Article
  4. Human TUBG2 gene is expressed as two splice variant mRNA and involved in cell growth. Ohashi T, et al. FEBS Lett, 2016 Apr. PMID 27015882
  5. The gamma-tubulin gene family in humans. Wise DO, et al. Genomics, 2000 Jul 15. PMID 10903841

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. that in the face of predominant gamma-tubulin-1 expression, the accumulation of gamma-tubulin-2 in mature neurons and neuroblastoma cells during oxidative stress may denote a prosurvival role of gamma-tubulin-2 in neurons
    Title: Differential expression of human γ-tubulin isotypes during neuronal development and oxidative stress points to a γ-tubulin-2 prosurvival function.
  2. expression of gamma-tubulin2 along with gamma-tubulin1 and a novel TUBG2 splice variant are identified.
    Title: Human TUBG2 gene is expressed as two splice variant mRNA and involved in cell growth.
  3. Our results reveal for the first time an increased expression of TUBG1 and TUBG2 in lung cancer
    Title: Overexpression of γ-tubulin in non-small cell lung cancer.
  4. gamma-tubulin 2 is able to nucleate microtubules and substitute for gamma-tubulin 1
    Title: γ-Tubulin 2 nucleates microtubules and is downregulated in mouse early embryogenesis.
  5. Observational study of gene-disease association. (HuGE Navigator)
    Title: Centrosome-related genes, genetic variation, and risk of breast cancer.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat K29A, K50R, and K51R lysine mutations downregulate the proportion of soluble tubulin in cells, while the majority of other lysine mutations upregulate the percentage of soluble tubulin compared with the wild-type PubMed
tat HIV-1 Tat (specifically, amino acids 38-72), enhances tubulin polymerization and triggers the mitochondrial pathway to induce T cell apoptosis as shown in vitro by the release of cytochrome c from isolated mitochondria PubMed
Vpr vpr HIV-1 Vpr-expressing HeLa cells stained with centriole markers pericentrin, gamma-tubulin, and Cen2 contain multiple pairs of centrioles scattered in the perinuclear region, indicating Vpr causes the accumulation of multiple centrosome-like structures PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC131994

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural molecule activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytoplasmic microtubule organization IEA
Inferred from Electronic Annotation
more info
  
involved_in meiotic spindle organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule nucleation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic sister chromatid segregation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic spindle organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of gamma-tubulin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in microtubule cytoskeleton TAS
Traceable Author Statement
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in pericentriolar material IEA
Inferred from Electronic Annotation
more info
  
is_active_in spindle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle microtubule IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
tubulin gamma-2 chain
Names
gamma-2-tubulin
tubulin gamma 2 chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001320509.2 → NP_001307438.1  tubulin gamma-2 chain isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC067852, BE727957, BI819869
    UniProtKB/TrEMBL
    A0A1B4Z394, A0A7P0T9G6
    Conserved Domains (1) summary
    cd02188
    Location:3 → 444
    gamma_tubulin; The gamma-tubulin family

  2. NM_016437.3 → NP_057521.1  tubulin gamma-2 chain isoform 2

    See identical proteins and their annotated locations for NP_057521.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform 2 which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    BC108739, DC353745
    Consensus CDS
    CCDS32658.1
    UniProtKB/Swiss-Prot
    A6NDI4, Q32NB2, Q9NRH3
    UniProtKB/TrEMBL
    A0A7P0T9G6
    Related
    ENSP00000251412.6, ENST00000251412.8
    Conserved Domains (1) summary
    cd02188
    Location:3 → 435
    gamma_tubulin; The gamma-tubulin family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    42659284..42667006
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047435757.1 → XP_047291713.1  tubulin gamma-2 chain isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    43516421..43524145
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054315727.1 → XP_054171702.1  tubulin gamma-2 chain isoform X1

  2. XM_054315728.1 → XP_054171703.1  tubulin gamma-2 chain isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NRH3.1 GenPept UniProtKB/Swiss-Prot:Q9NRH3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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