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Cdk15 cyclin dependent kinase 15 [ Mus musculus (house mouse) ]

Gene ID: 271697, updated on 11-Apr-2024

Summary

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Official Symbol
Cdk15provided by MGI
Official Full Name
cyclin dependent kinase 15provided by MGI
Primary source
MGI:MGI:3583944
See related
Ensembl:ENSMUSG00000026023 AllianceGenome:MGI:3583944
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pftk2; Als2cr7
Summary
Predicted to enable cyclin binding activity and cyclin-dependent protein serine/threonine kinase activity. Predicted to be involved in protein phosphorylation and regulation of transcription involved in G1/S transition of mitotic cell cycle. Predicted to act upstream of or within phosphorylation. Predicted to be active in cytosol and nucleus. Orthologous to human CDK15 (cyclin dependent kinase 15). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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Location:
1 C1.3- C2; 1 29.47 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (59296029..59391656)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (59256861..59352497)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4) Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:59219938-59220121 Neighboring gene alsin Rho guanine nucleotide exchange factor Neighboring gene STARR-positive B cell enhancer ABC_E1993 Neighboring gene predicted gene, 33667 Neighboring gene STARR-seq mESC enhancer starr_01032 Neighboring gene VISTA enhancer mm1575 Neighboring gene VISTA enhancer mm489 Neighboring gene predicted gene, 51625 Neighboring gene STARR-seq mESC enhancer starr_01034 Neighboring gene predicted gene, 33724 Neighboring gene STARR-seq mESC enhancer starr_01037 Neighboring gene STARR-seq mESC enhancer starr_01039 Neighboring gene predicted gene, 33774

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
  2. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  3. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables cyclin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cyclin-dependent kinase 15
Names
PFTAIRE protein kinase 2
amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 7
amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein homolog
cell division protein kinase 15
serine/threonine-protein kinase ALS2CR7
serine/threonine-protein kinase PFTAIRE-2
NP_001028545.2
NP_001343318.1
XP_006496111.1
XP_006496112.1
XP_011236833.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033373.3 → NP_001028545.2  cyclin-dependent kinase 15 isoform 1

    See identical proteins and their annotated locations for NP_001028545.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC116995, AC132361, AC153652
    Consensus CDS
    CCDS48273.1
    UniProtKB/Swiss-Prot
    B2RVR3, B7ZWG3, Q3V3A1
    UniProtKB/TrEMBL
    E3W997
    Related
    ENSMUSP00000109886.3, ENSMUST00000114248.3
    Conserved Domains (2) summary
    PLN00009
    Location:101 → 385
    PLN00009; cyclin-dependent kinase A; Provisional
    cd07870
    Location:100 → 385
    STKc_PFTAIRE2; Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-2 kinase

  2. NM_001356389.1 → NP_001343318.1  cyclin-dependent kinase 15 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC116995, AC132361, AC153652
    UniProtKB/TrEMBL
    E3W997
    Conserved Domains (1) summary
    cd07870
    Location:99 → 384
    STKc_PFTAIRE2; Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-2 kinase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    59296029..59391656
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006496049.5 → XP_006496112.1  cyclin-dependent kinase 15 isoform X2

    UniProtKB/TrEMBL
    E3W997
    Conserved Domains (1) summary
    cl21453
    Location:99 → 399
    PKc_like; Protein Kinases, catalytic domain

  2. XM_006496048.5 → XP_006496111.1  cyclin-dependent kinase 15 isoform X1

    UniProtKB/TrEMBL
    E3W997
    Conserved Domains (1) summary
    cd07870
    Location:100 → 400
    STKc_PFTAIRE2; Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-2 kinase

  3. XM_011238531.3 → XP_011236833.1  cyclin-dependent kinase 15 isoform X3

    Conserved Domains (1) summary
    cl21453
    Location:10 → 214
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_373255.5 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3V3A1.2 GenPept UniProtKB/Swiss-Prot:Q3V3A1

Gene LinkOut

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