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BRPF3 bromodomain and PHD finger containing 3 [ Homo sapiens (human) ]

Gene ID: 27154, updated on 10-Dec-2024

Summary

Official Symbol
BRPF3provided by HGNC
Official Full Name
bromodomain and PHD finger containing 3provided by HGNC
Primary source
HGNC:HGNC:14256
See related
Ensembl:ENSG00000096070 MIM:616856; AllianceGenome:HGNC:14256
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Contributes to histone acetyltransferase activity. Involved in positive regulation of DNA replication. Located in nucleus. Part of MOZ/MORF histone acetyltransferase complex. [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in testis (RPKM 15.9), kidney (RPKM 10.5) and 25 other tissues See more
Orthologs
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Genomic context

See BRPF3 in Genome Data Viewer
Location:
6p21.31
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (36196744..36232790)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (36017037..36053081)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (36164521..36200567)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase 14 Neighboring gene NUDT5 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24416 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17106 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24417 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24418 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17107 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:36098441-36099044 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17109 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24420 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:36106471-36106971 Neighboring gene mitogen-activated protein kinase 13 Neighboring gene BRPF3 antisense RNA 1 Neighboring gene MPRA-validated peak5782 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17110 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24421 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:36203227-36203772 Neighboring gene Sharpr-MPRA regulatory region 10771 Neighboring gene uncharacterized LOC105375036 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17111 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:36235945-36236531 Neighboring gene patatin like phospholipase domain containing 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:36253718-36253903 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:36269917-36270417 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24422 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24423 Neighboring gene BCL2 interacting protein 5

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Interactions

General gene information

Gene Ontology Provided by GOA

Component Evidence Code Pubs
part_of MOZ/MORF histone acetyltransferase complex  
part_of MOZ/MORF histone acetyltransferase complex PubMed 
part_of MOZ/MORF histone acetyltransferase complex  
located_in cytosol  
located_in extracellular region  
part_of histone acetyltransferase complex PubMed 
located_in nucleus PubMed 
located_in nucleus  

General protein information

Preferred Names
bromodomain and PHD finger-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015695.3NP_056510.2  bromodomain and PHD finger-containing protein 3

    See identical proteins and their annotated locations for NP_056510.2

    Status: VALIDATED

    Source sequence(s)
    AB033112, BC039615, Z84485
    Consensus CDS
    CCDS34437.1
    UniProtKB/Swiss-Prot
    A6ND56, A6NJE2, B7ZLN5, E7EX85, Q17RB6, Q5R3K8, Q9ULD4
    UniProtKB/TrEMBL
    E9PI60
    Related
    ENSP00000350267.6, ENST00000357641.10
    Conserved Domains (6) summary
    cd05839
    Location:10741189
    BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
    cd05512
    Location:593690
    Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
    cd15572
    Location:212265
    PHD_BRPF; PHD finger found in bromodomain and PHD finger-containing (BRPF) proteins
    cd15703
    Location:269386
    ePHD_BRPF3; Extended PHD finger found in bromodomain and PHD finger-containing protein 3 (BRPF3) and similar proteins
    pfam10513
    Location:48194
    EPL1; Enhancer of polycomb-like
    pfam15429
    Location:848972
    DUF4628; Domain of unknown function (DUF4628)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    36196744..36232790
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011514490.2XP_011512792.1  bromodomain and PHD finger-containing protein 3 isoform X1

    UniProtKB/TrEMBL
    E9PI60
    Conserved Domains (6) summary
    cd05512
    Location:593690
    Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
    cd15572
    Location:212265
    PHD_BRPF; PHD finger found in bromodomain and PHD finger-containing (BRPF) proteins
    cd15703
    Location:269386
    ePHD_BRPF3; Extended PHD finger found in bromodomain and PHD finger-containing protein 3 (BRPF3) and similar proteins
    pfam10513
    Location:48194
    EPL1; Enhancer of polycomb-like
    pfam15429
    Location:848972
    DUF4628; Domain of unknown function (DUF4628)
    cl02554
    Location:10741144
    PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...
  2. XM_047418649.1XP_047274605.1  bromodomain and PHD finger-containing protein 3 isoform X6

    UniProtKB/Swiss-Prot
    A6ND56, A6NJE2, B7ZLN5, E7EX85, Q17RB6, Q5R3K8, Q9ULD4
    UniProtKB/TrEMBL
    E9PI60
    Related
    ENSP00000436504.1, ENST00000534400.5
  3. XM_011514491.2XP_011512793.1  bromodomain and PHD finger-containing protein 3 isoform X2

    UniProtKB/TrEMBL
    E9PI60
    Conserved Domains (7) summary
    cd05512
    Location:593690
    Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
    COG5076
    Location:528743
    COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
    cd15572
    Location:212265
    PHD_BRPF; PHD finger found in bromodomain and PHD finger-containing (BRPF) proteins
    cd15703
    Location:269386
    ePHD_BRPF3; Extended PHD finger found in bromodomain and PHD finger-containing protein 3 (BRPF3) and similar proteins
    pfam10513
    Location:48194
    EPL1; Enhancer of polycomb-like
    pfam15429
    Location:848972
    DUF4628; Domain of unknown function (DUF4628)
    cl02554
    Location:10741095
    PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...
  4. XM_047418650.1XP_047274606.1  bromodomain and PHD finger-containing protein 3 isoform X3

    UniProtKB/TrEMBL
    E9PI60
  5. XM_011514492.2XP_011512794.1  bromodomain and PHD finger-containing protein 3 isoform X4

    UniProtKB/TrEMBL
    E9PSF3
    Conserved Domains (4) summary
    cd05512
    Location:593690
    Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
    cd15572
    Location:212265
    PHD_BRPF; PHD finger found in bromodomain and PHD finger-containing (BRPF) proteins
    cd15703
    Location:269386
    ePHD_BRPF3; Extended PHD finger found in bromodomain and PHD finger-containing protein 3 (BRPF3) and similar proteins
    pfam10513
    Location:48194
    EPL1; Enhancer of polycomb-like
  6. XM_047418651.1XP_047274607.1  bromodomain and PHD finger-containing protein 3 isoform X5

    UniProtKB/TrEMBL
    F6XDC4, H0Y7B4
    Related
    ENSP00000437087.1, ENST00000532330.5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    36017037..36053081
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054355175.1XP_054211150.1  bromodomain and PHD finger-containing protein 3 isoform X7

    UniProtKB/TrEMBL
    E9PI60
  2. XM_054355176.1XP_054211151.1  bromodomain and PHD finger-containing protein 3 isoform X1

    UniProtKB/TrEMBL
    E9PI60
  3. XM_054355177.1XP_054211152.1  bromodomain and PHD finger-containing protein 3 isoform X2

    UniProtKB/TrEMBL
    E9PI60
  4. XM_054355178.1XP_054211153.1  bromodomain and PHD finger-containing protein 3 isoform X3

    UniProtKB/TrEMBL
    E9PI60
  5. XM_054355179.1XP_054211154.1  bromodomain and PHD finger-containing protein 3 isoform X4

    UniProtKB/TrEMBL
    E9PSF3
  6. XM_054355180.1XP_054211155.1  bromodomain and PHD finger-containing protein 3 isoform X5

    UniProtKB/TrEMBL
    F6XDC4, H0Y7B4
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