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INPP5J inositol polyphosphate-5-phosphatase J [ Homo sapiens (human) ]

Gene ID: 27124, updated on 7-Apr-2024

Summary

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Official Symbol
INPP5Jprovided by HGNC
Official Full Name
inositol polyphosphate-5-phosphatase Jprovided by HGNC
Primary source
HGNC:HGNC:8956
See related
Ensembl:ENSG00000185133 MIM:606481; AllianceGenome:HGNC:8956
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PIPP; INPP5; PIB5PA
Summary
Predicted to enable phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity and phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity. Predicted to be involved in inositol phosphate dephosphorylation; negative regulation of peptidyl-serine phosphorylation; and phosphatidylinositol dephosphorylation. Predicted to act upstream of or within negative regulation of neuron projection development. Located in cytoplasm and ruffle. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in thyroid (RPKM 63.8), small intestine (RPKM 7.6) and 4 other tissues See more
Orthologs
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Genomic context

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Location:
22q12.2
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (31122614..31134697)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (31571393..31598201)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (31518909..31530683)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372995 Neighboring gene uncharacterized LOC124905100 Neighboring gene ribosomal protein S15a pseudogene 37 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:31533780-31534280 Neighboring gene phospholipase A2 group III Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:31535998-31536556 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:31536557-31537116 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:31543860-31544038 Neighboring gene Sharpr-MPRA regulatory region 9733 Neighboring gene SNRPN pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. PI(4,5)P2 5-phosphatase A regulates PI3K/Akt signalling and has a tumour suppressive role in human melanoma. Ye Y, et al. Nat Commun, 2013. PMID 23443536, Free PMC Article
  2. MiR-661 contributed to cell proliferation of human ovarian cancer cells by repressing INPP5J expression. Zhu T, et al. Biomed Pharmacother, 2015 Oct. PMID 26282217
  3. miR-508 sustains phosphoinositide signalling and promotes aggressive phenotype of oesophageal squamous cell carcinoma. Lin C, et al. Nat Commun, 2014 Aug 6. PMID 25099196
  4. Novel inositol polyphosphate 5-phosphatase localizes at membrane ruffles. Mochizuki Y, et al. J Biol Chem, 1999 Dec 17. PMID 10593988
  5. A novel isoform of the smooth muscle cell differentiation marker smoothelin. Krämer J, et al. J Mol Med (Berl), 1999 Feb. PMID 10023782

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Suggest miR-661 functions as a tumor promoter by targeting the INPP5J gene, and then promoting cell proliferation of ovarian cancer cells.
    Title: MiR-661 contributed to cell proliferation of human ovarian cancer cells by repressing INPP5J expression.
  2. Findings indicate inositol polyphosphate 5-phosphatase PIPP (INPP5J) as a suppressor of oncogenic phosphoinositide 3-kinase (PI3K)/AKT signaling in breast cancer.
    Title: The Inositol Polyphosphate 5-Phosphatase PIPP Regulates AKT1-Dependent Breast Cancer Growth and Metastasis.
  3. miR-508 has a role in sustaining phosphoinositide signalling and promotes aggressive phenotype of oesophageal squamous cell carcinoma by suppressing INPP5J
    Title: miR-508 sustains phosphoinositide signalling and promotes aggressive phenotype of oesophageal squamous cell carcinoma.
  4. these results establish the tumour suppressive role of phosphatidylinositol 4,5-bisphosphate 5-phosphatase and reveal mechanisms involved in its downregulation in melanoma.
    Title: PI(4,5)P2 5-phosphatase A regulates PI3K/Akt signalling and has a tumour suppressive role in human melanoma.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC129984

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables SH3 domain binding IEA
Inferred from Electronic Annotation
more info
  
enables inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables inositol-1,4,5-trisphosphate 5-phosphatase activity TAS
Traceable Author Statement
more info
  
enables inositol-polyphosphate 5-phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity TAS
Traceable Author Statement
more info
  
enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in inositol phosphate metabolic process TAS
Traceable Author Statement
more info
  
involved_in negative regulation of neuron projection development IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylinositol biosynthetic process TAS
Traceable Author Statement
more info
  
involved_in phosphatidylinositol dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in dendritic shaft IEA
Inferred from Electronic Annotation
more info
  
located_in growth cone IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in ruffle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in ruffle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
phosphatidylinositol 4,5-bisphosphate 5-phosphatase A
Names
phosphatidylinositol 1,3,4,5-tetrakisphosphate 5-phosphatase
phosphatidylinositol 1,4,5-trisphosphate 5-phosphatase
NP_001002837.1
NP_001271214.1
NP_001271215.1
NP_001271216.1
NP_001271217.1
NP_001271218.1
NP_001410401.1
NP_001410402.1
NP_001410403.1
NP_001410404.1
NP_001410405.1
NP_001410406.1
NP_001410407.1
NP_001410408.1
NP_001410409.1
NP_001410410.1
NP_001410411.1
NP_001410412.1
XP_054181518.1
XP_054181519.1
XP_054181520.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002837.3 → NP_001002837.1  phosphatidylinositol 4,5-bisphosphate 5-phosphatase A isoform c

    See identical proteins and their annotated locations for NP_001002837.1

    Status: VALIDATED

    Source sequence(s)
    AC005005
    Consensus CDS
    CCDS46687.1
    UniProtKB/Swiss-Prot
    Q15735
    Related
    ENSP00000384534.3, ENST00000404390.7
    Conserved Domains (1) summary
    cd09094
    Location:56 → 362
    INPP5c_INPP5J-like; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of inositol polyphosphate 5-phosphatase J and related proteins

  2. NM_001284285.2 → NP_001271214.1  phosphatidylinositol 4,5-bisphosphate 5-phosphatase A isoform a

    See identical proteins and their annotated locations for NP_001271214.1

    Status: VALIDATED

    Source sequence(s)
    AC005005, AK092859, AK293992, AW014134
    Consensus CDS
    CCDS63453.1
    UniProtKB/Swiss-Prot
    B3KS54, Q15735, Q32M61, Q6ZTH6, Q8N902, Q9UDT9
    Related
    ENSP00000333262.5, ENST00000331075.10
    Conserved Domains (1) summary
    cd09094
    Location:423 → 730
    INPP5c_INPP5J-like; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of inositol polyphosphate 5-phosphatase J and related proteins

  3. NM_001284286.2 → NP_001271215.1  phosphatidylinositol 4,5-bisphosphate 5-phosphatase A isoform b

    See identical proteins and their annotated locations for NP_001271215.1

    Status: VALIDATED

    Source sequence(s)
    AC005005
    UniProtKB/TrEMBL
    B4DF95
    Related
    ENSP00000392924.2, ENST00000412277.6
    Conserved Domains (1) summary
    cd09094
    Location:356 → 663
    INPP5c_INPP5J-like; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of inositol polyphosphate 5-phosphatase J and related proteins

  4. NM_001284287.2 → NP_001271216.1  phosphatidylinositol 4,5-bisphosphate 5-phosphatase A isoform d

    Status: VALIDATED

    Source sequence(s)
    AC005005
    UniProtKB/TrEMBL
    A0A087WVS7
    Related
    ENSP00000479645.1, ENST00000620191.4
    Conserved Domains (1) summary
    cd09094
    Location:1 → 295
    INPP5c_INPP5J-like; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of inositol polyphosphate 5-phosphatase J and related proteins

  5. NM_001284288.2 → NP_001271217.1  phosphatidylinositol 4,5-bisphosphate 5-phosphatase A isoform e

    See identical proteins and their annotated locations for NP_001271217.1

    Status: VALIDATED

    Source sequence(s)
    AC005005
    UniProtKB/Swiss-Prot
    Q15735
    Related
    ENSP00000383150.2, ENST00000400294.6
    Conserved Domains (1) summary
    cd09094
    Location:56 → 363
    INPP5c_INPP5J-like; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of inositol polyphosphate 5-phosphatase J and related proteins

  6. NM_001284289.2 → NP_001271218.1  phosphatidylinositol 4,5-bisphosphate 5-phosphatase A isoform e

    See identical proteins and their annotated locations for NP_001271218.1

    Status: VALIDATED

    Source sequence(s)
    AC005005
    UniProtKB/Swiss-Prot
    Q15735
    Related
    ENSP00000384596.1, ENST00000405300.5
    Conserved Domains (1) summary
    cd09094
    Location:56 → 363
    INPP5c_INPP5J-like; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of inositol polyphosphate 5-phosphatase J and related proteins

  7. NM_001423472.1 → NP_001410401.1  phosphatidylinositol 4,5-bisphosphate 5-phosphatase A isoform a

    Status: VALIDATED

    Source sequence(s)
    AC005005
    UniProtKB/Swiss-Prot
    B3KS54, Q15735, Q32M61, Q6ZTH6, Q8N902, Q9UDT9

  8. NM_001423473.1 → NP_001410402.1  phosphatidylinositol 4,5-bisphosphate 5-phosphatase A isoform a

    Status: VALIDATED

    Source sequence(s)
    AC005005
    UniProtKB/Swiss-Prot
    B3KS54, Q15735, Q32M61, Q6ZTH6, Q8N902, Q9UDT9

  9. NM_001423474.1 → NP_001410403.1  phosphatidylinositol 4,5-bisphosphate 5-phosphatase A isoform f

    Status: VALIDATED

    Source sequence(s)
    AC005005

  10. NM_001423475.1 → NP_001410404.1  phosphatidylinositol 4,5-bisphosphate 5-phosphatase A isoform b

    Status: VALIDATED

    Source sequence(s)
    AC005005
    UniProtKB/TrEMBL
    B4DF95

  11. NM_001423476.1 → NP_001410405.1  phosphatidylinositol 4,5-bisphosphate 5-phosphatase A isoform b

    Status: VALIDATED

    Source sequence(s)
    AC005005
    UniProtKB/TrEMBL
    B4DF95

  12. NM_001423477.1 → NP_001410406.1  phosphatidylinositol 4,5-bisphosphate 5-phosphatase A isoform g

    Status: VALIDATED

    Source sequence(s)
    AC005005

  13. NM_001423478.1 → NP_001410407.1  phosphatidylinositol 4,5-bisphosphate 5-phosphatase A isoform e

    Status: VALIDATED

    Source sequence(s)
    AC005005

  14. NM_001423479.1 → NP_001410408.1  phosphatidylinositol 4,5-bisphosphate 5-phosphatase A isoform h

    Status: VALIDATED

    Source sequence(s)
    AC005005

  15. NM_001423480.1 → NP_001410409.1  phosphatidylinositol 4,5-bisphosphate 5-phosphatase A isoform i

    Status: VALIDATED

    Source sequence(s)
    AC005005

  16. NM_001423481.1 → NP_001410410.1  phosphatidylinositol 4,5-bisphosphate 5-phosphatase A isoform d

    Status: VALIDATED

    Source sequence(s)
    AC005005
    UniProtKB/TrEMBL
    A0A087WVS7

  17. NM_001423482.1 → NP_001410411.1  phosphatidylinositol 4,5-bisphosphate 5-phosphatase A isoform j

    Status: VALIDATED

    Source sequence(s)
    AC005005

  18. NM_001423483.1 → NP_001410412.1  phosphatidylinositol 4,5-bisphosphate 5-phosphatase A isoform k

    Status: VALIDATED

    Source sequence(s)
    AC005005
    UniProtKB/TrEMBL
    B5MCL8
    Related
    ENSP00000385264.1, ENST00000402238.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    31122614..31134697
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    31571393..31598201
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054325543.1 → XP_054181518.1  phosphatidylinositol 4,5-bisphosphate 5-phosphatase A isoform X2

  2. XM_054325545.1 → XP_054181520.1  phosphatidylinositol 4,5-bisphosphate 5-phosphatase A isoform X1

  3. XM_054325544.1 → XP_054181519.1  phosphatidylinositol 4,5-bisphosphate 5-phosphatase A isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_014422.2: Suppressed sequence

    Description
    NM_014422.2: This RefSeq was permanently suppressed because it has an additional exon that results in a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q15735.3 GenPept UniProtKB/Swiss-Prot:Q15735

Gene LinkOut

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