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Rubcnl RUN and cysteine rich domain containing beclin 1 interacting protein like [ Mus musculus (house mouse) ]

Gene ID: 271221, updated on 5-Mar-2024

Summary

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Official Symbol
Rubcnlprovided by MGI
Official Full Name
RUN and cysteine rich domain containing beclin 1 interacting protein likeprovided by MGI
Primary source
MGI:MGI:2685590
See related
Ensembl:ENSMUSG00000034959 AllianceGenome:MGI:2685590
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm744; Gm911; Kiaa0226l; 5031414D18Rik
Summary
Predicted to enable phosphatidylinositol-3-phosphate binding activity; phosphatidylinositol-4-phosphate binding activity; and phosphatidylinositol-5-phosphate binding activity. Involved in autophagosome maturation; regulation of glycogen metabolic process; and regulation of lipid metabolic process. Predicted to be located in cytoplasmic vesicle and membrane. Predicted to be active in autophagosome membrane. Orthologous to human RUBCNL (rubicon like autophagy enhancer). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in spleen adult (RPKM 8.9), mammary gland adult (RPKM 2.4) and 6 other tissues See more
Orthologs
human all
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Genomic context

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See Rubcnl in Genome Data Viewer
Location:
14 D3; 14 39.53 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (75253467..75289977)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (75015987..75052537)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene leucine-rich repeats and calponin homology (CH) domain containing 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:75346402-75346511 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:75346543-75346730 Neighboring gene STARR-positive B cell enhancer ABC_E5456 Neighboring gene predicted gene 10847 Neighboring gene STARR-seq mESC enhancer starr_37134 Neighboring gene STARR-positive B cell enhancer ABC_E10834 Neighboring gene predicted gene 4278 Neighboring gene STARR-positive B cell enhancer ABC_E757 Neighboring gene predicted gene, 57618 Neighboring gene STARR-positive B cell enhancer mm9_chr14:75456661-75456962 Neighboring gene STARR-positive B cell enhancer mm9_chr14:75460374-75460674 Neighboring gene STARR-seq mESC enhancer starr_37135 Neighboring gene leucine rich repeat containing 63 Neighboring gene predicted gene 15628 Neighboring gene lymphocyte cytosolic protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Pacer Is a Mediator of mTORC1 and GSK3-TIP60 Signaling in Regulation of Autophagosome Maturation and Lipid Metabolism. Cheng X, et al. Mol Cell, 2019 Feb 21. PMID 30704899
  2. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
  5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. mTORC1 and GSK3-TIP60 signaling converge to modulate autophagosome maturation and lipid metabolism through Pacer.
    Title: Pacer Is a Mediator of mTORC1 and GSK3-TIP60 Signaling in Regulation of Autophagosome Maturation and Lipid Metabolism.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Homology

Clone Names

  • MGC60829

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-3-phosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-4-phosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-5-phosphate binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in autophagosome maturation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in autophagosome maturation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in autophagosome maturation ISO
Inferred from Sequence Orthology
more info
  
involved_in autophagosome-endosome fusion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in autophagosome-endosome fusion ISO
Inferred from Sequence Orthology
more info
  
involved_in autophagosome-lysosome fusion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in autophagosome-lysosome fusion ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within autophagy IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of glycogen metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of lipid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in autophagosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in autophagosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein associated with UVRAG as autophagy enhancer
Names
pacer
protein RUBCNL-like
protein Rubicon-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001374214.1 → NP_001361143.1  protein associated with UVRAG as autophagy enhancer isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC146617
    Conserved Domains (1) summary
    pfam13901
    Location:252 → 447
    zf-RING_9; Putative zinc-RING and/or ribbon

  2. NM_198642.2 → NP_941044.3  protein associated with UVRAG as autophagy enhancer isoform 1

    See identical proteins and their annotated locations for NP_941044.3

    Status: VALIDATED

    Source sequence(s)
    AC146617
    Consensus CDS
    CCDS36977.1
    UniProtKB/TrEMBL
    F8WGX2, Q7TPZ3
    Related
    ENSMUSP00000045566.8, ENSMUST00000036072.8
    Conserved Domains (1) summary
    pfam13901
    Location:464 → 659
    zf-RING_9; Putative zinc-RING and/or ribbon

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    75253467..75289977
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158642.1 → XP_036014535.1  protein associated with UVRAG as autophagy enhancer isoform X2

    UniProtKB/TrEMBL
    Q7TPZ3
    Conserved Domains (1) summary
    pfam13901
    Location:435 → 537
    zf-RING_9; Putative zinc-RING and/or ribbon

  2. XM_030247841.2 → XP_030103701.1  protein associated with UVRAG as autophagy enhancer isoform X4

  3. XM_036158643.1 → XP_036014536.1  protein associated with UVRAG as autophagy enhancer isoform X3

  4. XM_036158644.1 → XP_036014537.1  protein associated with UVRAG as autophagy enhancer isoform X5

  5. XM_011245078.4 → XP_011243380.1  protein associated with UVRAG as autophagy enhancer isoform X1

    See identical proteins and their annotated locations for XP_011243380.1

    UniProtKB/TrEMBL
    F8WGX2, Q7TPZ3
    Conserved Domains (1) summary
    pfam13901
    Location:464 → 659
    zf-RING_9; Putative zinc-RING and/or ribbon
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3TD16.2 GenPept UniProtKB/Swiss-Prot:Q3TD16

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