Adamts16 ADAM metallopeptidase with thrombospondin type 1 motif 16 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Adamts16provided by MGI
Official Full Name: ADAM metallopeptidase with thrombospondin type 1 motif 16provided by MGI
Primary source: MGI:MGI:2429637
See related: Ensembl:ENSMUSG00000049538 AllianceGenome:MGI:2429637
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: This gene encodes a member of "a disintegrin and metalloproteinase with thrombospondin motifs" (ADAMTS) family of multi-domain matrix-associated metalloendopeptidases that have diverse roles in tissue morphogenesis and pathophysiological remodeling, in inflammation and in vascular biology. This gene is co-expressed with the Wilms tumor protein, Wt1, in the developing glomeruli of embryonic kidneys. The encoded preproprotein undergoes proteolytic processing to generate an active enzyme. [provided by RefSeq, Jul 2016]
Expression: Biased expression in cerebellum adult (RPKM 1.3), limb E14.5 (RPKM 1.1) and 14 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 C1; 13 35.97 cM

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (70875917..70989956, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (70727798..70841845, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Extracellular Matrix Disorganization Caused by ADAMTS16 Deficiency Leads to Bicuspid Aortic Valve With Raphe Formation.
Title: Extracellular Matrix Disorganization Caused by ADAMTS16 Deficiency Leads to Bicuspid Aortic Valve With Raphe Formation.
ADAMTS16 activates latent TGF-beta, accentuating fibrosis and dysfunction of the pressure-overloaded heart.
Title: ADAMTS16 activates latent TGF-β, accentuating fibrosis and dysfunction of the pressure-overloaded heart.
ADAMTS16 impairs FN fibrillogenesis as well as fibrillin-1 and tenascin-C assembly, thus inhibiting formation of a mature extracellular matrix by cultured fibroblasts.
Title: A Selective Extracellular Matrix Proteomics Approach Identifies Fibronectin Proteolysis by A Disintegrin-like and Metalloprotease Domain with Thrombospondin Type 1 Motifs (ADAMTS16) and Its Impact on Spheroid Morphogenesis.
Adamts16 is involved in branching morphogenesis of the kidneys in mice downstream of Wt1
Title: Transcriptional regulation by the Wilms tumor protein, Wt1, suggests a role of the metalloproteinase Adamts16 in murine genitourinary development.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D1Mco108 (e-PCR)
- UniSTS:527726

Adamts16 (e-PCR), detects polymorphism
- UniSTS:532644

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metallopeptidase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within branching involved in ureteric bud morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in extracellular matrix organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in male gamete generation	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of systemic arterial blood pressure	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: A disintegrin and metalloproteinase with thrombospondin motifs 16

Names: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 16; a disintegrin-like and metallopetidase (reprolysin type) with thrombospondin type 1 motif, 16; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 16 preproprotein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001426387.1 → NP_001413316.1 A disintegrin and metalloproteinase with thrombospondin motifs 16 isoform 2

Status: REVIEWED

Source sequence(s)

AC160108
NM_172053.4 → NP_742050.2 A disintegrin and metalloproteinase with thrombospondin motifs 16 preproprotein

See identical proteins and their annotated locations for NP_742050.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the shorter transcript and encodes the functional protein.

Source sequence(s)

AC160108

Consensus CDS

CCDS36723.1

UniProtKB/Swiss-Prot

Q69Z28, Q8K206

Related

ENSMUSP00000079041.7, ENSMUST00000080145.13

Conserved Domains (6) summary

smart00209
Location:587 → 639

TSP1; Thrombospondin type 1 repeats

cd04273
Location:288 → 489

ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...

pfam01421
Location:290 → 493

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:88 → 187

Pep_M12B_propep; Reprolysin family propeptide

pfam05986
Location:745 → 856

ADAM_spacer1; ADAM-TS Spacer 1

pfam08686
Location:1188 → 1218

PLAC; PLAC (protease and lacunin) domain

RNA

NR_137640.1 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC160108, AK031314, CX216861

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

70875917..70989956 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006517268.5 → XP_006517331.1 A disintegrin and metalloproteinase with thrombospondin motifs 16 isoform X3

Conserved Domains (6) summary

smart00209
Location:582 → 634

TSP1; Thrombospondin type 1 repeats

cd04273
Location:283 → 484

ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...

pfam01562
Location:52 → 198

Pep_M12B_propep; Reprolysin family propeptide

pfam05986
Location:740 → 851

ADAM_spacer1; ADAM-TS Spacer 1

pfam08686
Location:1183 → 1213

PLAC; PLAC (protease and lacunin) domain

pfam17771
Location:501 → 568

ADAM_CR_2; ADAM cysteine-rich domain
XM_006517267.5 → XP_006517330.1 A disintegrin and metalloproteinase with thrombospondin motifs 16 isoform X2

Conserved Domains (6) summary

smart00209
Location:583 → 635

TSP1; Thrombospondin type 1 repeats

cd04273
Location:284 → 485

ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...

pfam01562
Location:53 → 199

Pep_M12B_propep; Reprolysin family propeptide

pfam05986
Location:741 → 852

ADAM_spacer1; ADAM-TS Spacer 1

pfam08686
Location:1184 → 1214

PLAC; PLAC (protease and lacunin) domain

pfam17771
Location:502 → 569

ADAM_CR_2; ADAM cysteine-rich domain
XM_006517266.5 → XP_006517329.1 A disintegrin and metalloproteinase with thrombospondin motifs 16 isoform X1

Conserved Domains (6) summary

smart00209
Location:586 → 638

TSP1; Thrombospondin type 1 repeats

cd04273
Location:287 → 488

ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...

pfam01562
Location:56 → 202

Pep_M12B_propep; Reprolysin family propeptide

pfam05986
Location:744 → 855

ADAM_spacer1; ADAM-TS Spacer 1

pfam08686
Location:1187 → 1217

PLAC; PLAC (protease and lacunin) domain

pfam17771
Location:505 → 572

ADAM_CR_2; ADAM cysteine-rich domain
XM_030247289.2 → XP_030103149.1 A disintegrin and metalloproteinase with thrombospondin motifs 16 isoform X4

Conserved Domains (5) summary

smart00209
Location:356 → 408

TSP1; Thrombospondin type 1 repeats

cd04273
Location:57 → 258

ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...

pfam05986
Location:514 → 625

ADAM_spacer1; ADAM-TS Spacer 1

pfam08686
Location:957 → 987

PLAC; PLAC (protease and lacunin) domain

pfam17771
Location:275 → 342

ADAM_CR_2; ADAM cysteine-rich domain
XM_011244525.4 → XP_011242827.1 A disintegrin and metalloproteinase with thrombospondin motifs 16 isoform X4

Conserved Domains (5) summary

smart00209
Location:356 → 408

TSP1; Thrombospondin type 1 repeats

cd04273
Location:57 → 258

ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...

pfam05986
Location:514 → 625

ADAM_spacer1; ADAM-TS Spacer 1

pfam08686
Location:957 → 987

PLAC; PLAC (protease and lacunin) domain

pfam17771
Location:275 → 342

ADAM_CR_2; ADAM cysteine-rich domain
XM_017315523.3 → XP_017171012.1 A disintegrin and metalloproteinase with thrombospondin motifs 16 isoform X6

Conserved Domains (5) summary

smart00209
Location:217 → 269

TSP1; Thrombospondin type 1 repeats

pfam05986
Location:375 → 486

ADAM_spacer1; ADAM-TS Spacer 1

pfam08686
Location:818 → 848

PLAC; PLAC (protease and lacunin) domain

pfam17771
Location:136 → 203

ADAM_CR_2; ADAM cysteine-rich domain

cl00064
Location:2 → 119

ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...
XM_006517270.5 → XP_006517333.1 A disintegrin and metalloproteinase with thrombospondin motifs 16 isoform X5

Related

ENSMUSP00000105316.3, ENSMUST00000109694.3

Conserved Domains (5) summary

smart00209
Location:587 → 639

TSP1; Thrombospondin type 1 repeats

cd04273
Location:288 → 489

ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...

pfam01562
Location:57 → 203

Pep_M12B_propep; Reprolysin family propeptide

pfam05986
Location:745 → 856

ADAM_spacer1; ADAM-TS Spacer 1

pfam17771
Location:506 → 573

ADAM_CR_2; ADAM cysteine-rich domain
XM_036158063.1 → XP_036013956.1 A disintegrin and metalloproteinase with thrombospondin motifs 16 isoform X8

UniProtKB/TrEMBL

D6RGS8

Related

ENSMUSP00000122031.2, ENSMUST00000123552.8

Conserved Domains (4) summary

smart00209
Location:587 → 639

TSP1; Thrombospondin type 1 repeats

cd04273
Location:288 → 489

ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...

pfam01562
Location:88 → 203

Pep_M12B_propep; Reprolysin family propeptide

pfam17771
Location:506 → 573

ADAM_CR_2; ADAM cysteine-rich domain
XM_006517273.5 → XP_006517336.1 A disintegrin and metalloproteinase with thrombospondin motifs 16 isoform X9

UniProtKB/TrEMBL

D6RGS8

Conserved Domains (4) summary

smart00209
Location:587 → 639

TSP1; Thrombospondin type 1 repeats

cd04273
Location:288 → 489

ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...

pfam01562
Location:57 → 203

Pep_M12B_propep; Reprolysin family propeptide

pfam17771
Location:506 → 573

ADAM_CR_2; ADAM cysteine-rich domain
XM_006517272.5 → XP_006517335.1 A disintegrin and metalloproteinase with thrombospondin motifs 16 isoform X7

UniProtKB/TrEMBL

D6RGS8

Conserved Domains (4) summary

smart00209
Location:587 → 639

TSP1; Thrombospondin type 1 repeats

cd04273
Location:288 → 489

ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...

pfam01562
Location:57 → 203

Pep_M12B_propep; Reprolysin family propeptide

pfam17771
Location:506 → 573

ADAM_CR_2; ADAM cysteine-rich domain