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Tmem132e transmembrane protein 132E [ Mus musculus (house mouse) ]

Gene ID: 270893, updated on 5-Mar-2024

Summary

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Official Symbol
Tmem132eprovided by MGI
Official Full Name
transmembrane protein 132Eprovided by MGI
Primary source
MGI:MGI:2685490
See related
Ensembl:ENSMUSG00000020701 AllianceGenome:MGI:2685490
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm644
Summary
Predicted to be involved in posterior lateral line neuromast hair cell development. Located in cell body. Is expressed in medulla oblongata; medulla oblongata basal plate; and pons. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 99. Orthologous to human TMEM132E (transmembrane protein 132E). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in placenta adult (RPKM 5.4), cerebellum adult (RPKM 3.2) and 18 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 C; 11 50.08 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (82279281..82338447)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (82388852..82447621)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene C-C motif chemokine ligand 1 Neighboring gene STARR-seq mESC enhancer starr_30173 Neighboring gene predicted gene, 38577 Neighboring gene predicted gene, 53691 Neighboring gene predicted gene, 24612

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Heterogeneity of breakpoints in non-LCR-mediated large constitutional deletions of the 17q11.2 NF1 tumour suppressor region. Kehrer-Sawatzki H, et al. J Med Genet, 2003 Oct. PMID 14569139, Free PMC Article
  2. Whole-exome sequencing identifies a variant in TMEM132E causing autosomal-recessive nonsyndromic hearing loss DFNB99. Li J, et al. Hum Mutat, 2015 Jan. PMID 25331638
  3. Differential expression of the Tmem132 family genes in the developing mouse nervous system. Wang Y, et al. Gene Expr Patterns, 2022 Sep. PMID 35690356, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in posterior lateral line neuromast hair cell development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transmembrane protein 132E

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304439.2 → NP_001291368.1  transmembrane protein 132E precursor

    Status: VALIDATED

    Source sequence(s)
    AL645797
    Consensus CDS
    CCDS25144.2
    UniProtKB/Swiss-Prot
    A0A0A0MQ93, B7ZN59, Q5SUX0, Q6IEE6
    UniProtKB/TrEMBL
    A0A494B870
    Related
    ENSMUSP00000052484.5, ENSMUST00000054245.8
    Conserved Domains (3) summary
    pfam15705
    Location:45 → 175
    TMEM132D_N; Mature oligodendrocyte transmembrane protein, TMEM132D, N-term
    pfam15706
    Location:877 → 942
    TMEM132D_C; Mature oligodendrocyte transmembrane protein, TMEM132D, C-term
    pfam16070
    Location:451 → 796
    TMEM132; Transmembrane protein family 132

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    82279281..82338447
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006533452.5 → XP_006533515.1  transmembrane protein 132E isoform X2

    Conserved Domains (2) summary
    pfam15705
    Location:45 → 176
    TMEM132D_N; Mature oligodendrocyte transmembrane protein, TMEM132D, N-term
    pfam16070
    Location:451 → 797
    TMEM132; Transmembrane protein family 132

  2. XM_036156736.1 → XP_036012629.1  transmembrane protein 132E isoform X3

    Conserved Domains (2) summary
    pfam15706
    Location:581 → 646
    TMEM132D_C; Mature oligodendrocyte transmembrane protein, TMEM132D, C-term
    pfam16070
    Location:155 → 501
    TMEM132; Transmembrane protein family 132

  3. XM_006533449.5 → XP_006533512.1  transmembrane protein 132E isoform X1

    UniProtKB/TrEMBL
    A0A494B870
    Conserved Domains (3) summary
    pfam15705
    Location:47 → 178
    TMEM132D_N; Mature oligodendrocyte transmembrane protein, TMEM132D, N-term
    pfam15706
    Location:879 → 944
    TMEM132D_C; Mature oligodendrocyte transmembrane protein, TMEM132D, C-term
    pfam16070
    Location:453 → 799
    TMEM132; Transmembrane protein family 132

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_023438.2: Suppressed sequence

    Description
    NM_023438.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6IEE6.2 GenPept UniProtKB/Swiss-Prot:Q6IEE6

Gene LinkOut

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