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MTBP MDM2 binding protein [ Homo sapiens (human) ]

Gene ID: 27085, updated on 5-Mar-2024

Summary

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Official Symbol
MTBPprovided by HGNC
Official Full Name
MDM2 binding proteinprovided by HGNC
Primary source
HGNC:HGNC:7417
See related
Ensembl:ENSG00000172167 MIM:605927; AllianceGenome:HGNC:7417
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MDM2BP
Summary
This gene encodes a protein that interacts with the oncoprotein mouse double minute 2. The encoded protein regulates progression through the cell cycle and may be involved in tumor formation. [provided by RefSeq, Aug 2012]
Expression
Broad expression in testis (RPKM 2.1), lymph node (RPKM 1.4) and 24 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
8q24.12
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (120445419..120523636)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (121574164..121652088)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (121457659..121535876)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene collagen type XIV alpha 1 chain Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:121250945-121251444 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:121278472-121279056 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:121409422-121409610 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:121409635-121410134 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27849 Neighboring gene mitochondrial ribosomal protein L13 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr8:121567323-121568522 Neighboring gene syntrophin beta 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:121637686-121638215 Neighboring gene non-SMC condensin I complex subunit G pseudogene 1 Neighboring gene NANOG hESC enhancer GRCh37_chr8:121697522-121698069 Neighboring gene uncharacterized LOC101927543

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. MTBP inhibits migration and metastasis of hepatocellular carcinoma. Bi Q, et al. Clin Exp Metastasis, 2015 Apr. PMID 25759210, Free PMC Article
  2. MTBP is overexpressed in triple-negative breast cancer and contributes to its growth and survival. Grieb BC, et al. Mol Cancer Res, 2014 Sep. PMID 24866769, Free PMC Article
  3. MDM2 binding protein, a novel metastasis suppressor. Iwakuma T, et al. Cancer Metastasis Rev, 2012 Dec. PMID 22684342
  4. Loss of MTBP expression is associated with reduced survival in a biomarker-defined subset of patients with squamous cell carcinoma of the head and neck. Vlatković N, et al. Cancer, 2011 Jul 1. PMID 21692053
  5. Assignment of the MDM2 binding protein gene (MTBP) to human chromosome band 8q24 by in situ hybridization. Boyd MT, et al. Cytogenet Cell Genet, 2000. PMID 11060448

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Binding of the Treslin-MTBP Complex to Specific Regions of the Human Genome Promotes the Initiation of DNA Replication.
    Title: Binding of the Treslin-MTBP Complex to Specific Regions of the Human Genome Promotes the Initiation of DNA Replication.
  2. data show that MTBP aggravates the invasion and metastasis of HCC by promoting the MDM2-mediated degradation of E-cadherin.
    Title: MTBP Promotes the Invasion and Metastasis of Hepatocellular Carcinoma by Enhancing the MDM2-Mediated Degradation of E-Cadherin.
  3. Overexpression of MTBP resulted in the suppression of the migratory and metastatic potential of Hepatocellular carcinoma cells, while its downregulation increased the migration.
    Title: MTBP inhibits migration and metastasis of hepatocellular carcinoma.
  4. MTBP significantly contributes to breast cancer survival and is a potential novel therapeutic target in Triple-negative breast cancer .
    Title: MTBP is overexpressed in triple-negative breast cancer and contributes to its growth and survival.
  5. MTBP associated with MYC at promoters and increased MYC-mediated transcription, proliferation, neoplastic transformation, and tumor development.
    Title: Oncogenic protein MTBP interacts with MYC to promote tumorigenesis.
  6. MTBP acts with Treslin/TICRR to integrate signals from cell cycle and DNA damage response pathways to control the initiation of DNA replication in human cells.
    Title: Identification of a heteromeric complex that promotes DNA replication origin firing in human cells.
  7. MTBP also inhibited ACTN4-mediated F-actin bundling.
    Title: MTBP suppresses cell migration and filopodia formation by inhibiting ACTN4.
  8. identification and characterization of mouse Mdm2 binding protein
    Title: A novel cellular protein (MTBP) binds to MDM2 and induces a G1 arrest that is suppressed by MDM2.
  9. MTBP has an important role in recruiting and/or retaining the Mad1/Mad2 complex at the kinetochores during prometaphase, but its degradation is required for silencing the mitotic checkpoint.
    Title: MTBP plays a crucial role in mitotic progression and chromosome segregation.
  10. results represent the first examination of MTBP expression in human tissues and provide evidence for a p53 status-dependent role for MTBP in suppressing disease progression in squamous cell carcinoma of the head and neck patients
    Title: Loss of MTBP expression is associated with reduced survival in a biomarker-defined subset of patients with squamous cell carcinoma of the head and neck.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Epidemiological and genome-wide association study of gastritis or gastric ulcer in korean populations.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of mitotic nuclear division IEA
Inferred from Electronic Annotation
more info
  
involved_in protein localization to kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein localization to kinetochore IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in traversing start control point of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
mdm2-binding protein
Names
MDM2 (mouse double minute 2)-binding protein, 104kD
Mdm2, transformed 3T3 cell double minute 2, p53 binding protein binding protein, 104kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033151.1 RefSeqGene

    Range
    5022..83239
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_022045.5 → NP_071328.2  mdm2-binding protein

    See identical proteins and their annotated locations for NP_071328.2

    Status: REVIEWED

    Source sequence(s)
    AC105142, AC107877, BC013136
    Consensus CDS
    CCDS6333.1
    UniProtKB/Swiss-Prot
    B4DUR5, Q96DY7, Q9HA89
    Related
    ENSP00000303398.1, ENST00000305949.6
    Conserved Domains (3) summary
    pfam14918
    Location:1 → 270
    MTBP_N; MDM2-binding
    pfam14919
    Location:294 → 632
    MTBP_mid; MDM2-binding
    pfam14920
    Location:636 → 894
    MTBP_C; MDM2-binding

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    120445419..120523636
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011516962.3 → XP_011515264.1  mdm2-binding protein isoform X1

    Conserved Domains (3) summary
    pfam14918
    Location:1 → 270
    MTBP_N; MDM2-binding
    pfam14919
    Location:294 → 632
    MTBP_mid; MDM2-binding
    pfam14920
    Location:636 → 660
    MTBP_C; MDM2-binding

  2. XM_011516963.3 → XP_011515265.1  mdm2-binding protein isoform X2

    Conserved Domains (2) summary
    pfam14918
    Location:1 → 270
    MTBP_N; MDM2-binding
    pfam14919
    Location:294 → 483
    MTBP_mid; MDM2-binding

RNA

  1. XR_928318.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    121574164..121652088
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054360293.1 → XP_054216268.1  mdm2-binding protein isoform X1

  2. XM_054360294.1 → XP_054216269.1  mdm2-binding protein isoform X2

RNA

  1. XR_008487835.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96DY7.1 GenPept UniProtKB/Swiss-Prot:Q96DY7

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