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Zfp275 zinc finger protein 275 [ Mus musculus (house mouse) ]

Gene ID: 27081, updated on 27-Feb-2024

Summary

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Official Symbol
Zfp275provided by MGI
Official Full Name
zinc finger protein 275provided by MGI
Primary source
MGI:MGI:1350985
See related
Ensembl:ENSMUSG00000031365 AllianceGenome:MGI:1350985
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DXPas8; DXBay20; DXHXS52; 5430431L06Rik
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including genitourinary system; heart; hemolymphoid system gland; liver; and lung. Orthologous to human ZNF275 (zinc finger protein 275). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 10.4), ovary adult (RPKM 6.4) and 28 other tissues See more
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Genomic context

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See Zfp275 in Genome Data Viewer
Location:
X A7.3; X 37.29 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (72386190..72402686)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (73342593..73359080)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 32150 Neighboring gene paraneoplastic antigen MA3 pseudogene Neighboring gene PNMA family member 6E Neighboring gene zinc finger protein 92

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Encyclopedia of the mouse genome III. October 1993. Mouse X chromosome. Brown SD, et al. Mamm Genome, 1993. PMID 8268681
  2. Localization of the region homologous to the Duchenne muscular dystrophy locus on the mouse X chromosome. Heilig R, et al. Nature, 1987 Jul 9-15. PMID 3600794
  3. Detailed ordering of markers localizing to the Xq26-Xqter region of the human X chromosome by the use of an interspecific Mus spretus mouse cross. Avner P, et al. Proc Natl Acad Sci U S A, 1987 Mar. PMID 2882509, Free PMC Article
  4. Comparative mapping on the mouse and human X chromosomes of a human cDNA clone encoding the vasopressin renal-type receptor (AVP2R). Faust CJ, et al. Genomics, 1993 Feb. PMID 8449515
  5. Physical mapping of the loci Gabra3, DXPas8, CamL1, and Rsvp in a region of the mouse X chromosome homologous to human Xq28. Faust CJ, et al. Genomics, 1991 Sep. PMID 1684949

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 275

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001160229.1 → NP_001153701.1  zinc finger protein 275 isoform 2

    See identical proteins and their annotated locations for NP_001153701.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an internal exon, resulting in a downstream AUG start codon, as compared to variant 1. The resulting isoform (2) has a much shorter N-terminus, as compared to isoform 1.
    Source sequence(s)
    AK142957, AL732461
    Consensus CDS
    CCDS53097.1
    UniProtKB/TrEMBL
    Q3UQ14
    Related
    ENSMUSP00000110143.2, ENSMUST00000114499.8
    Conserved Domains (4) summary
    COG5048
    Location:128 → 343
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:243 → 263
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:49 → 69
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:255 → 280
    zf-H2C2_2; Zinc-finger double domain

  2. NM_031494.2 → NP_113682.2  zinc finger protein 275 isoform 1

    See identical proteins and their annotated locations for NP_113682.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL732461, BC138003, BY010614, CF535607, CJ130997
    Consensus CDS
    CCDS30199.2
    UniProtKB/TrEMBL
    G3X904
    Related
    ENSMUSP00000033731.4, ENSMUST00000033731.4
    Conserved Domains (5) summary
    COG5048
    Location:250 → 465
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:365 → 385
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:171 → 191
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:365 → 385
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:377 → 402
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    72386190..72402686
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006528055.5 → XP_006528118.1  zinc finger protein 275 isoform X1

    Conserved Domains (2) summary
    COG5048
    Location:83 → 336
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:213 → 233
    ZF_C2H2; C2H2 Zn finger [structural motif]
Nucleotide Protein Strain
Heading Accession and Version

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