U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Fkbp9 FK506 binding protein 9 [ Mus musculus (house mouse) ]

Gene ID: 27055, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Fkbp9provided by MGI
Official Full Name
FK506 binding protein 9provided by MGI
Primary source
MGI:MGI:1350921
See related
Ensembl:ENSMUSG00000029781 AllianceGenome:MGI:1350921
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FKBP-9; FKBP60; FKBP63; FKBP-63; FKBP65RS; 1810014L23
Summary
Enables calcium ion binding activity. Involved in protein folding. Located in endoplasmic reticulum. Is expressed in several structures, including genitourinary system; incisor; respiratory system; sensory organ; and skeleton. Orthologous to human FKBP9 (FKBP prolyl isomerase 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in limb E14.5 (RPKM 82.0), bladder adult (RPKM 56.0) and 24 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Fkbp9 in Genome Data Viewer
Location:
6 B3; 6 27.74 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (56809044..56856345)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (56832059..56879360)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E679 Neighboring gene AVL9 cell migration associated Neighboring gene STARR-seq mESC enhancer starr_15991 Neighboring gene kelch repeat and BTB (POZ) domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E4829 Neighboring gene predicted gene 10209 Neighboring gene STARR-seq mESC enhancer starr_15993 Neighboring gene STARR-seq mESC enhancer starr_15995 Neighboring gene 5'-nucleotidase, cytosolic III Neighboring gene predicted gene, 53332 Neighboring gene STARR-positive B cell enhancer ABC_E8830 Neighboring gene STARR-seq mESC enhancer starr_15996 Neighboring gene vomeronasal 1 receptor 4

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Identification and genetic mapping of the mouse Fkbp9 gene encoding a new member of FK506-binding protein family. Jo D, et al. Mol Cells, 2001 Oct 31. PMID 11710534
  2. Biochemical analysis of mouse FKBP60, a novel member of the FKPB family. Shadidy M, et al. Biochim Biophys Acta, 1999 Sep 3. PMID 10524204
  3. Insights into developmental mechanisms and cancers in the mammalian intestine derived from serial analysis of gene expression and study of the hepatoma-derived growth factor (HDGF). Lepourcelet M, et al. Development, 2005 Jan. PMID 15604097
  4. Hepatic lipase maturation: a partial proteome of interacting factors. Doolittle MH, et al. J Lipid Res, 2009 Jun. PMID 19136429, Free PMC Article
  5. Single-cell gene profiling defines differential progenitor subclasses in mammalian neurogenesis. Kawaguchi A, et al. Development, 2008 Sep. PMID 18725516

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Identification and genetic mapping of the mouse Fkbp9 gene encoding a new member of FK506-binding protein family.
    Title: Identification and genetic mapping of the mouse Fkbp9 gene encoding a new member of FK506-binding protein family.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables peptidyl-prolyl cis-trans isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein folding IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
peptidyl-prolyl cis-trans isomerase FKBP9
Names
63 kDa FK506-binding protein
63 kDa FKBP
PPIase FKBP9
rotamase
NP_036186.2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012056.2 → NP_036186.2  peptidyl-prolyl cis-trans isomerase FKBP9 precursor

    See identical proteins and their annotated locations for NP_036186.2

    Status: VALIDATED

    Source sequence(s)
    AK007499, BB794531, BC043129
    Consensus CDS
    CCDS39494.1
    UniProtKB/Swiss-Prot
    Q80ZZ6, Q8R386, Q9CVM0, Q9JHX5, Q9Z247
    Related
    ENSMUSP00000031795.8, ENSMUST00000031795.8
    Conserved Domains (3) summary
    cd00051
    Location:497 → 558
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00254
    Location:47 → 139
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
    pfam13499
    Location:495 → 559
    EF-hand_7; EF-hand domain pair

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    56809044..56856345
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z247.1 GenPept UniProtKB/Swiss-Prot:Q9Z247

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous