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Nit1 nitrilase 1 [ Mus musculus (house mouse) ]

Gene ID: 27045, updated on 5-Mar-2024

Summary

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Official Symbol
Nit1provided by MGI
Official Full Name
nitrilase 1provided by MGI
Primary source
MGI:MGI:1350916
See related
Ensembl:ENSMUSG00000013997 AllianceGenome:MGI:1350916
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ESTM30
Summary
Enables deaminated glutathione amidase activity. Involved in cellular amide catabolic process. Located in mitochondrion. Is expressed in several structures, including genitourinary system; liver; mammary gland; musculature; and spleen. Orthologous to human NIT1 (nitrilase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 60.8), testis adult (RPKM 53.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 H3; 1 79.35 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (171168145..171173209, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (171340571..171345656, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 25151 Neighboring gene predicted gene, 20045 Neighboring gene death effector domain-containing Neighboring gene STARR-positive B cell enhancer ABC_E2019 Neighboring gene prefoldin 2 Neighboring gene STARR-positive B cell enhancer ABC_E4387 Neighboring gene kelch domain containing 9 Neighboring gene nectin cell adhesion molecule 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mammalian nitrilase 1 homologue Nit1 is a negative regulator in T cells. Zhang H, et al. Int Immunol, 2009 Jun. PMID 19395373, Free PMC Article
  2. Nit1 and Fhit tumor suppressor activities are additive. Sun J, et al. J Cell Biochem, 2009 Aug 15. PMID 19479888, Free PMC Article
  3. Nitrilase 1 modulates lung tumor progression in vitro and in vivo. Wang YA, et al. Oncotarget, 2016 Apr 19. PMID 26967383, Free PMC Article
  4. Effect of zinc supplementation on N-nitrosomethylbenzylamine-induced forestomach tumor development and progression in tumor suppressor-deficient mouse strains. Sun J, et al. Carcinogenesis, 2011 Mar. PMID 21097531, Free PMC Article
  5. Functional proteomic and structural insights into molecular recognition in the nitrilase family enzymes. Barglow KT, et al. Biochemistry, 2008 Dec 23. PMID 19053248, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that cisplatin response was enhanced in human lung cancer cells when Nit1 was knocked down and mice Nit1-/-:KrasG12D/+ tumors showed increased sensitivity to cisplatin in vivo.
    Title: Nitrilase 1 modulates lung tumor progression in vitro and in vivo.
  2. the extent of tumor susceptibility due to Nit1 and Fhit deficiency is additive
    Title: Nit1 and Fhit tumor suppressor activities are additive.
  3. genetic deficiency results in T cell hyperproliferative responses induced by TCR stimulation, spontaneous cell cycle entry and enhanced cell cycle progression
    Title: Mammalian nitrilase 1 homologue Nit1 is a negative regulator in T cells.
  4. Nit1 and Fhit share tumor suppressor signaling pathways, while localization of the NIT1 gene at a stable chromosome site explains the paucity of gene alterations and in frequent loss of expression of the NIT1 gene in human malignancies.
    Title: Biological functions of mammalian Nit1, the counterpart of the invertebrate NitFhit Rosetta stone protein, a possible tumor suppressor.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables deaminated glutathione amidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in amide catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nitrogen compound metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
deaminated glutathione amidase
Names
dGSH amidase
nitrilase homolog 1
NP_001229509.1
NP_001407610.1
NP_001407611.1
NP_001407612.1
NP_001407613.1
NP_036179.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001242580.2 → NP_001229509.1  deaminated glutathione amidase isoform 2

    See identical proteins and their annotated locations for NP_001229509.1

    Status: VALIDATED

    Source sequence(s)
    AC087229
    Consensus CDS
    CCDS56656.1
    UniProtKB/Swiss-Prot
    Q8VDK1
    Related
    ENSMUSP00000106920.2, ENSMUST00000111289.8
    Conserved Domains (1) summary
    cd07572
    Location:11 → 278
    nit; Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases)

  2. NM_001420681.1 → NP_001407610.1  deaminated glutathione amidase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC087229

  3. NM_001420682.1 → NP_001407611.1  deaminated glutathione amidase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC087229

  4. NM_001420683.1 → NP_001407612.1  deaminated glutathione amidase isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC087229

  5. NM_001420684.1 → NP_001407613.1  deaminated glutathione amidase isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC087229

  6. NM_012049.3 → NP_036179.1  deaminated glutathione amidase isoform 1

    See identical proteins and their annotated locations for NP_036179.1

    Status: VALIDATED

    Source sequence(s)
    AC087229
    Consensus CDS
    CCDS35775.1
    UniProtKB/Swiss-Prot
    O88526, Q8VDK1, Q9R1N4
    Related
    ENSMUSP00000106926.2, ENSMUST00000111295.8
    Conserved Domains (1) summary
    cd07572
    Location:44 → 311
    nit; Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    171168145..171173209 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VDK1.2 GenPept UniProtKB/Swiss-Prot:Q8VDK1

Gene LinkOut

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