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G3bp1 G3BP stress granule assembly factor 1 [ Mus musculus (house mouse) ]

Gene ID: 27041, updated on 21-Apr-2024

Summary

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Official Symbol
G3bp1provided by MGI
Official Full Name
G3BP stress granule assembly factor 1provided by MGI
Primary source
MGI:MGI:1351465
See related
Ensembl:ENSMUSG00000018583 AllianceGenome:MGI:1351465
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
G3bp; mKIAA4115; B430204O07
Summary
Enables mRNA binding activity. Acts upstream of or within negative regulation of canonical Wnt signaling pathway. Located in cytoplasmic stress granule. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human G3BP1 (G3BP stress granule assembly factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 53.7), limb E14.5 (RPKM 33.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 B1.3; 11 33.09 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (55360521..55391722)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (55469657..55500888)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_29542 Neighboring gene STARR-seq mESC enhancer starr_29544 Neighboring gene antioxidant 1 copper chaperone Neighboring gene STARR-positive B cell enhancer ABC_E373 Neighboring gene predicted gene 12235 Neighboring gene predicted gene 12238 Neighboring gene microRNA 7652 Neighboring gene predicted gene 12236 Neighboring gene glycine receptor, alpha 1 subunit

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Diverse CMT2 neuropathies are linked to aberrant G3BP interactions in stress granules. Cui Q, et al. Cell, 2023 Feb 16. PMID 36738734
  2. Noroviruses subvert the core stress granule component G3BP1 to promote viral VPg-dependent translation. Hosmillo M, et al. Elife, 2019 Aug 12. PMID 31403400, Free PMC Article
  3. Preferential binding of a stable G3BP ribonucleoprotein complex to intron-retaining transcripts in mouse brain and modulation of their expression in the cerebellum. Martin S, et al. J Neurochem, 2016 Nov. PMID 27513819
  4. GTPase Activating Protein (Sh3 Domain) Binding Protein 1 Regulates the Processing of MicroRNA-1 during Cardiac Hypertrophy. He M, et al. PLoS One, 2015. PMID 26675618, Free PMC Article
  5. Deficiency of G3BP1, the stress granules assembly factor, results in abnormal synaptic plasticity and calcium homeostasis in neurons. Martin S, et al. J Neurochem, 2013 Apr. PMID 23373770

See all (75) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SIRT2 negatively regulates the cGAS-STING pathway by deacetylating G3BP1.
    Title: SIRT2 negatively regulates the cGAS-STING pathway by deacetylating G3BP1.
  2. The stress granule protein G3BP1 alleviates spinocerebellar ataxia-associated deficits.
    Title: The stress granule protein G3BP1 alleviates spinocerebellar ataxia-associated deficits.
  3. Diverse CMT2 neuropathies are linked to aberrant G3BP interactions in stress granules.
    Title: Diverse CMT2 neuropathies are linked to aberrant G3BP interactions in stress granules.
  4. Huntington's disease mice and human brain tissue exhibit increased G3BP1 granules and TDP43 mislocalization.
    Title: Huntington's disease mice and human brain tissue exhibit increased G3BP1 granules and TDP43 mislocalization.
  5. G3BP1 Inhibition Alleviates Intracellular Nucleic Acid-Induced Autoimmune Responses.
    Title: G3BP1 Inhibition Alleviates Intracellular Nucleic Acid-Induced Autoimmune Responses.
  6. A Ca(2+)-Dependent Switch Activates Axonal Casein Kinase 2alpha Translation and Drives G3BP1 Granule Disassembly for Axon Regeneration.
    Title: A Ca(2+)-Dependent Switch Activates Axonal Casein Kinase 2α Translation and Drives G3BP1 Granule Disassembly for Axon Regeneration.
  7. Replacement of endogenous G3BP1 with the K376Q mutant or the RNA binding-deficient F380L/F382L mutant interfered with SG formation. Significant G3BP1 K376 acetylation was detected during SG resolution, and K376-acetylated G3BP1 was seen outside SGs. G3BP1 acetylation is regulated by histone deacetylase 6 (HDAC6) and CBP/p300.
    Title: The Acetylation of Lysine-376 of G3BP1 Regulates RNA Binding and Stress Granule Dynamics.
  8. By combining three complimentary approaches, the authors identify the host protein G3BP1 as a critical host factor required for norovirus VPg-dependent translation, identifying a new role for G3BP1 in virus-specific translation.
    Title: Noroviruses subvert the core stress granule component G3BP1 to promote viral VPg-dependent translation.
  9. We show that murine norovirus (MNV) further prevents the formation of cytoplasmic stress granules, by recruiting the key host protein G3BP1 to the MNV replication complex, a recruitment that is crucial to establishing and maintaining virus replication.
    Title: Mouse Norovirus Infection Arrests Host Cell Translation Uncoupled from the Stress Granule-PKR-eIF2α Axis.
  10. this paper shows that G3BP1 promotes DNA binding and activation of cyclic GMP-AMP synthase
    Title: G3BP1 promotes DNA binding and activation of cGAS.
Submit: New GeneRIF Correction See all GeneRIFs (22)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA4115

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA helicase activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA/RNA helicase activity ISO
Inferred from Sequence Orthology
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA helicase activity ISO
Inferred from Sequence Orthology
more info
  
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables molecular condensate scaffold activity ISO
Inferred from Sequence Orthology
more info
  
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ribosomal small subunit binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in defense response to virus ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of stress granule assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of type I interferon production ISO
Inferred from Sequence Orthology
more info
  
involved_in stress granule assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasmic stress granule ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ras GTPase-activating protein-binding protein 1
Names
ATP-dependent DNA helicase VIII
G3BP-1
GAP SH3 binding protein
GAP SH3 domain-binding protein 1
GTPase activating protein (SH3 domain) binding protein 1
HDH-VIII
Ras-GTPase-activating protein SH3-domain binding protein 1
NP_001404512.1
NP_001404513.1
NP_001404514.1
NP_001404516.1
NP_038744.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001417583.1 → NP_001404512.1  ras GTPase-activating protein-binding protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL596207

  2. NM_001417584.1 → NP_001404513.1  ras GTPase-activating protein-binding protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL596207
    UniProtKB/TrEMBL
    Q3UR88

  3. NM_001417585.1 → NP_001404514.1  ras GTPase-activating protein-binding protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL596207

  4. NM_001417587.1 → NP_001404516.1  ras GTPase-activating protein-binding protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL596207

  5. NM_013716.3 → NP_038744.1  ras GTPase-activating protein-binding protein 1 isoform 1

    See identical proteins and their annotated locations for NP_038744.1

    Status: VALIDATED

    Source sequence(s)
    AL596207
    Consensus CDS
    CCDS24714.1
    UniProtKB/Swiss-Prot
    P97855
    UniProtKB/TrEMBL
    Q571F9
    Related
    ENSMUSP00000018727.4, ENSMUST00000018727.4
    Conserved Domains (4) summary
    PRK13733
    Location:210 → 310
    PRK13733; conjugal transfer protein TraV; Provisional
    COG0724
    Location:266 → 418
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd00780
    Location:7 → 135
    NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
    cd12463
    Location:335 → 414
    RRM_G3BP1; RNA recognition motif found in ras GTPase-activating protein-binding protein 1 (G3BP1) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    55360521..55391722
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P97855.1 GenPept UniProtKB/Swiss-Prot:P97855

Gene LinkOut

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