U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ZBTB32 zinc finger and BTB domain containing 32 [ Homo sapiens (human) ]

Gene ID: 27033, updated on 3-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
ZBTB32provided by HGNC
Official Full Name
zinc finger and BTB domain containing 32provided by HGNC
Primary source
HGNC:HGNC:16763
See related
Ensembl:ENSG00000011590 MIM:605859; AllianceGenome:HGNC:16763
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Rog; FAXF; FAZF; TZFP; mynn; ZNF538
Summary
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; identical protein binding activity; and sequence-specific double-stranded DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis (RPKM 13.5), lymph node (RPKM 1.5) and 2 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
19q13.12
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (35704558..35717038)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (38249885..38262352)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (36195460..36207940)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene UPK1A antisense RNA 1 Neighboring gene uroplakin 1A Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:36174493-36174994 Neighboring gene thymidylate synthetase pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14492 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14493 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14494 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10532 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:36207458-36208017 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10533 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10534 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10535 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:36209137-36209694 Neighboring gene lysine methyltransferase 2B Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:36230671-36231301 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10538 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14496 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14497 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:36234871-36235031 Neighboring gene IGF like family receptor 1 Neighboring gene U2 small nuclear RNA auxiliary factor 1 like 4

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Identification of FAZF as a novel BMP2-induced transcription factor during osteoblastic differentiation. Ikeda R, et al. J Cell Biochem, 2007 May 1. PMID 17171645
  2. Identification and gene structure of a novel human PLZF-related transcription factor gene, TZFP. Lin W, et al. Biochem Biophys Res Commun, 1999 Nov 2. PMID 10544010
  3. ZBTB32 Restricts the Duration of Memory B Cell Recall Responses. Jash A, et al. J Immunol, 2016 Aug 15. PMID 27357154, Free PMC Article
  4. Insights into strand exchange in BTB domain dimers from the crystal structures of FAZF and Miz1. Stogios PJ, et al. J Mol Biol, 2010 Jul 30. PMID 20493880
  5. The effects of the Fanconi anemia zinc finger (FAZF) on cell cycle, apoptosis, and proliferation are differentiation stage-specific. Dai MS, et al. J Biol Chem, 2002 Jul 19. PMID 11986317

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ZBTB32 is a novel negative regulator of antibody recall responses.
    Title: ZBTB32 Restricts the Duration of Memory B Cell Recall Responses.
  2. confirmed that the promyelocytic leukemia zinc finger (PLZF) BTB dimer is strand exchanged in solution, while the FAZF BTB dimer is not
    Title: Insights into strand exchange in BTB domain dimers from the crystal structures of FAZF and Miz1.
  3. Here, it was shown that human endogenous retrovirus Rec can form a trimeric complex with TZFP and AR, and can relieve the TZFP-mediated repression of AR-induced transactivation.
    Title: Human endogenous retrovirus protein Rec interacts with the testicular zinc-finger protein and androgen receptor.
  4. TZFP is identified as a novel BMP2-induced transcription factor during osteoblastic differentiation.
    Title: Identification of FAZF as a novel BMP2-induced transcription factor during osteoblastic differentiation.
  5. results suggest an essential role for FAZF during the proliferative stages of primitive hematopoietic progenitors, possibly acting in concert with (a subset of) the Fanconi anemia proteins
    Title: The effects of the Fanconi anemia zinc finger (FAZF) on cell cycle, apoptosis, and proliferation are differentiation stage-specific.
  6. can interact with GATA-2 and can modify GATA-2 transactivation capacity
    Title: Interactions of GATA-2 with the promyelocytic leukemia zinc finger (PLZF) protein, its homologue FAZF, and the t(11;17)-generated PLZF-retinoic acid receptor alpha oncoprotein.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of cytokine production IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of immune system process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of chromatin ISA
Inferred from Sequence Alignment
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
zinc finger and BTB domain-containing protein 32
Names
FANCC-interacting protein
fanconi anemia zinc finger protein
myoneurin
repressor of GATA
testis zinc finger protein
zinc finger protein 538

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001316902.2 → NP_001303831.1  zinc finger and BTB domain-containing protein 32 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AF130255, HY027719, HY039545
    UniProtKB/Swiss-Prot
    Q9Y2Y4
    Conserved Domains (2) summary
    sd00017
    Location:98 → 118
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:111 → 132
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001316903.2 → NP_001303832.1  zinc finger and BTB domain-containing protein 32 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice junction and lacks an alternate exon compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AF130255, BX095236, HY027719
    UniProtKB/Swiss-Prot
    Q9Y2Y4
    Conserved Domains (2) summary
    COG5048
    Location:41 → 91
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:43 → 63
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. NM_014383.3 → NP_055198.1  zinc finger and BTB domain-containing protein 32 isoform 1

    See identical proteins and their annotated locations for NP_055198.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AF130255, HY027719
    Consensus CDS
    CCDS12471.1
    UniProtKB/Swiss-Prot
    Q8WVP2, Q9Y2Y4
    Related
    ENSP00000376035.1, ENST00000392197.7
    Conserved Domains (3) summary
    COG5048
    Location:373 → 423
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:375 → 395
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02518
    Location:23 → 109
    BTB; BTB/POZ domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    35704558..35717038
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017026591.2 → XP_016882080.1  zinc finger and BTB domain-containing protein 32 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    38249885..38262352
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054320532.1 → XP_054176507.1  zinc finger and BTB domain-containing protein 32 isoform X3

    UniProtKB/Swiss-Prot
    Q8WVP2, Q9Y2Y4

  2. XM_054320531.1 → XP_054176506.1  zinc finger and BTB domain-containing protein 32 isoform X2

  3. XM_054320535.1 → XP_054176510.1  zinc finger and BTB domain-containing protein 32 isoform X6

    UniProtKB/TrEMBL
    A0A0C4DGF1

  4. XM_054320536.1 → XP_054176511.1  zinc finger and BTB domain-containing protein 32 isoform X1

  5. XM_054320533.1 → XP_054176508.1  zinc finger and BTB domain-containing protein 32 isoform X4

  6. XM_054320534.1 → XP_054176509.1  zinc finger and BTB domain-containing protein 32 isoform X5

  7. XM_054320537.1 → XP_054176512.1  zinc finger and BTB domain-containing protein 32 isoform X7

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y2Y4.1 GenPept UniProtKB/Swiss-Prot:Q9Y2Y4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous