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Tspan32 tetraspanin 32 [ Mus musculus (house mouse) ]

Gene ID: 27027, updated on 11-Apr-2024

Summary

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Official Symbol
Tspan32provided by MGI
Official Full Name
tetraspanin 32provided by MGI
Primary source
MGI:MGI:1350360
See related
Ensembl:ENSMUSG00000000244 AllianceGenome:MGI:1350360
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Art-1; Phemx; Tssc6; D7Wsu37e
Summary
Acts upstream of or within several processes, including defense response to protozoan; integrin-mediated signaling pathway; and negative regulation of myeloid dendritic cell activation. Located in cell surface. Part of integrin alphaIIb-beta3 complex. Is expressed in several structures, including central nervous system; ganglia; immune system; placenta; and tongue. Orthologous to human TSPAN32 (tetraspanin 32). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in spleen adult (RPKM 20.5), liver E14.5 (RPKM 17.8) and 10 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 F5; 7 88.09 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (142558644..142573223)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (143004907..143019486)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene tyrosine hydroxylase Neighboring gene achaete-scute family bHLH transcription factor 2 Neighboring gene STARR-positive B cell enhancer ABC_E4987 Neighboring gene STARR-positive B cell enhancer ABC_E6616 Neighboring gene expressed sequence R74862 Neighboring gene STARR-seq mESC enhancer starr_20520 Neighboring gene STARR-positive B cell enhancer ABC_E6617 Neighboring gene STARR-seq mESC enhancer starr_20521 Neighboring gene nonconserved acetylation island sequence M93 enhancer Neighboring gene CD81 antigen Neighboring gene tumor-suppressing subchromosomal transferable fragment 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The gene trap resource: a treasure trove for hemopoiesis research. Forrai A, et al. Exp Hematol, 2005 Aug. PMID 16038776
  2. The absence of Tssc6, a member of the tetraspanin superfamily, does not affect lymphoid development but enhances in vitro T-cell proliferative responses. Tarrant JM, et al. Mol Cell Biol, 2002 Jul. PMID 12077330, Free PMC Article
  3. A hematopoietic-specific transmembrane protein, Art-1, is possibly regulated by AML1. Harada Y, et al. Biochem Biophys Res Commun, 2001 Jun 15. PMID 11396961
  4. TSPAN32 suppresses chronic myeloid leukemia pathogenesis and progression by stabilizing PTEN. Qiu Q, et al. Signal Transduct Target Ther, 2023 Mar 1. PMID 36854750, Free PMC Article
  5. A complementary role for tetraspanin superfamily member TSSC6 and ADP purinergic P2Y(12) receptor in platelets. Makkawi M, et al. Thromb Res, 2018 Jan. PMID 29178985

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TSPAN32 suppresses chronic myeloid leukemia pathogenesis and progression by stabilizing PTEN.
    Title: TSPAN32 suppresses chronic myeloid leukemia pathogenesis and progression by stabilizing PTEN.
  2. Study demonstrates a complementary role between TSSC6 and P2Y12 receptor in platelets in regulating 'outside in' integrin alphaIIbbeta3 signalling thrombus growth and stability.
    Title: A complementary role for tetraspanin superfamily member TSSC6 and ADP purinergic P2Y(12) receptor in platelets.
  3. The absence of Tssc6, a member of the tetraspanin superfamily, does not affect lymphoid development but enhances in vitro T-cell proliferative responses.
    Title: The absence of Tssc6, a member of the tetraspanin superfamily, does not affect lymphoid development but enhances in vitro T-cell proliferative responses.
  4. absence of platelet TSSC6 affects the secondary stability of arterial thrombi in vivo upon vascular injury
    Title: Impaired "outside-in" integrin alphaIIbbeta3 signaling and thrombus stability in TSSC6-deficient mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2)  1 citation
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of T cell proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within blood coagulation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within defense response to protozoan IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within hemostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within integrin-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of T cell proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within negative regulation of myeloid dendritic cell activation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within platelet aggregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of defense response to virus IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
part_of integrin alphaIIb-beta3 complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in intracellular anatomical structure IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
tetraspanin-32
Names
AML1-regulated transmembrane protein 1
pan hematopoietic expression
protein Phemx
tspan-32
tumor-suppressing subchromosomal transferable fragment 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001128080.2 → NP_001121552.1  tetraspanin-32 isoform a

    See identical proteins and their annotated locations for NP_001121552.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AY039000
    Consensus CDS
    CCDS52459.1
    UniProtKB/Swiss-Prot
    Q923G9, Q9ESH0, Q9JHH2, Q9JHQ9, Q9JHR0, Q9JHR1, Q9JHR2, Q9JHS8
    Related
    ENSMUSP00000009396.7, ENSMUST00000009396.13
    Conserved Domains (2) summary
    cd03153
    Location:113 → 228
    PHEMX_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), PHEMX_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
    pfam00335
    Location:11 → 223
    Tetraspannin; Tetraspanin family

  2. NM_001128081.1 → NP_001121553.1  tetraspanin-32 isoform c

    See identical proteins and their annotated locations for NP_001121553.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (c) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform a.
    Source sequence(s)
    AJ279792, BY208601
    Consensus CDS
    CCDS52460.1
    UniProtKB/TrEMBL
    Q7TNQ7
    Related
    ENSMUSP00000080668.6, ENSMUST00000082008.12
    Conserved Domains (1) summary
    cd03153
    Location:86 → 173
    PHEMX_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), PHEMX_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...

  3. NM_001128082.1 → NP_001121554.1  tetraspanin-32 isoform d

    See identical proteins and their annotated locations for NP_001121554.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence and lacks two alternate in-frame exons compared to variant 1. The resulting isoform (d) is shorter at the N-terminus and lacks two alternate internal segment compared to isoform a.
    Source sequence(s)
    AJ279794, BY208601
    Consensus CDS
    CCDS52461.1
    UniProtKB/TrEMBL
    G3X9S3
    Related
    ENSMUSP00000101543.2, ENSMUST00000105923.8
    Conserved Domains (1) summary
    cl02781
    Location:47 → 139
    tetraspanin_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the ...

  4. NM_020286.3 → NP_064682.1  tetraspanin-32 isoform b

    See identical proteins and their annotated locations for NP_064682.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AF291425, BY208601
    Consensus CDS
    CCDS22037.1
    UniProtKB/TrEMBL
    D3Z0S2, Q3U3L6
    Related
    ENSMUSP00000074667.6, ENSMUST00000075172.12
    Conserved Domains (1) summary
    cd03153
    Location:86 → 201
    PHEMX_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), PHEMX_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    142558644..142573223
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006508624.4 → XP_006508687.1  tetraspanin-32 isoform X6

    Conserved Domains (2) summary
    cd03153
    Location:128 → 191
    PHEMX_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), PHEMX_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
    pfam00335
    Location:11 → 171
    Tetraspannin; Tetraspanin family

  2. XM_006508620.4 → XP_006508683.1  tetraspanin-32 isoform X2

    Conserved Domains (2) summary
    cd03153
    Location:128 → 210
    PHEMX_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), PHEMX_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
    pfam00335
    Location:11 → 171
    Tetraspannin; Tetraspanin family

  3. XM_006508625.4 → XP_006508688.1  tetraspanin-32 isoform X7

    Conserved Domains (1) summary
    cd03153
    Location:74 → 166
    PHEMX_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), PHEMX_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...

  4. XM_006508619.4 → XP_006508682.1  tetraspanin-32 isoform X1

    Conserved Domains (2) summary
    cd03153
    Location:128 → 238
    PHEMX_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), PHEMX_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
    pfam00335
    Location:11 → 171
    Tetraspannin; Tetraspanin family

  5. XM_006508622.4 → XP_006508685.1  tetraspanin-32 isoform X4

    Conserved Domains (2) summary
    cd03153
    Location:113 → 200
    PHEMX_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), PHEMX_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
    pfam00335
    Location:11 → 161
    Tetraspannin; Tetraspanin family

  6. XM_006508623.4 → XP_006508686.1  tetraspanin-32 isoform X5

    Conserved Domains (1) summary
    cl02781
    Location:74 → 194
    tetraspanin_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the ...

  7. XM_006508621.4 → XP_006508684.1  tetraspanin-32 isoform X3

    UniProtKB/TrEMBL
    D3Z0S2
    Related
    ENSMUSP00000115344.2, ENSMUST00000143512.3
    Conserved Domains (1) summary
    cd03153
    Location:94 → 203
    PHEMX_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), PHEMX_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JHH2.2 GenPept UniProtKB/Swiss-Prot:Q9JHH2

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