Ephb1 Eph receptor B1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ephb1provided by MGI
Official Full Name: Eph receptor B1provided by MGI
Primary source: MGI:MGI:1096337
See related: Ensembl:ENSMUSG00000032537 AllianceGenome:MGI:1096337
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Elk; Net; Cek6; Elkh; Hek6; 9330129L11; C130099E04Rik
Summary: Enables axon guidance receptor activity. Involved in several processes, including dendritic spine morphogenesis; detection of temperature stimulus involved in sensory perception of pain; and negative regulation of satellite cell differentiation. Acts upstream of or within several processes, including axonogenesis; ephrin receptor signaling pathway; and optic nerve morphogenesis. Located in several cellular components, including axon; filopodium tip; and membrane raft. Is active in glutamatergic synapse. Is expressed in several structures, including 1st branchial arch; brain; lower urinary tract; sensory organ; and vascular system. Orthologous to human EPHB1 (EPH receptor B1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in whole brain E14.5 (RPKM 16.5), CNS E18 (RPKM 12.9) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 F1; 9 54.15 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (101799327..102231892, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (101922128..102354693, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

EphB1 controls long-range cortical axon guidance through a cell non-autonomous role in GABAergic cells.
Title: EphB1 controls long-range cortical axon guidance through a cell non-autonomous role in GABAergic cells.
EphB1 promotes the differentiation and maturation of dendritic cells in non-small cell lung cancer.
Title: EphB1 promotes the differentiation and maturation of dendritic cells in non-small cell lung cancer.
Investigating the effects of compound paralogous EPHB receptor mutations on mouse facial development.
Title: Investigating the effects of compound paralogous EPHB receptor mutations on mouse facial development.
Identification of tetracycline combinations as EphB1 tyrosine kinase inhibitors for treatment of neuropathic pain.
Title: Identification of tetracycline combinations as EphB1 tyrosine kinase inhibitors for treatment of neuropathic pain.
EphB1 interaction with caveolin-1 in endothelial cells modulates caveolae biogenesis.
Title: EphB1 interaction with caveolin-1 in endothelial cells modulates caveolae biogenesis.
Porf-2 is capable of binding to the EphB1 receptor, causing the outgrowth of axons to stop and retract upon EphB forward signal transduction within the axon growth cone.
Title: Neuronal GAP-Porf-2 transduces EphB1 signaling to brake axon growth.
EphA2 mAb treatment could partially inhibit LPSinduced inactivation of EphBEphrin B3 signalling, while Ephrin B3 overexpression could abrogate LPSinduced activation of EphA2Ephrin A1 signalling. EphB1/Ephrin B3 signalling may antagonise the EphA2/Ephrin A1dependent pathway following LPS treatment
Title: Eph/ephrin signalling serves a bidirectional role in lipopolysaccharide‑induced intestinal injury.
ephrin type-B receptor 1 (EphB1) is upregulated in injured motor neurons, which in turn can activate astrocytes through ephrin-B1-mediated stimulation of signal transducer and activator of transcription-3 (STAT3)
Title: A neuroprotective astrocyte state is induced by neuronal signal EphB1 but fails in ALS models.
SUMOylation of EphB1 repressed activation of its downstream signaling molecule PKC-gamma, and consequently inhibited neuroblastoma tumorigenesis.
Title: Sumoylation of EphB1 Suppresses Neuroblastoma Tumorigenesis via Inhibiting PKCγ Activation.
Findings suggest that a combination of forward and reverse EphB1/2 receptor-mediated signaling contribute to posterior branch of the anterior commissure and corpus callosum axon guidance
Title: EphB1 and EphB2 intracellular domains regulate the formation of the corpus callosum and anterior commissure.

Submit: New GeneRIF Correction See all GeneRIFs (38)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation
Endonuclease-mediated (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Ephb1 (e-PCR), detects polymorphism
- UniSTS:506883

Ephb1 (e-PCR), detects polymorphism
- UniSTS:495887

D9Mit358 (e-PCR), detects polymorphism
- UniSTS:131924

D9Mgc10 (e-PCR), detects polymorphism
- UniSTS:142749

D9Mgc11 (e-PCR), detects polymorphism
- UniSTS:142750

D9Mgc32 (e-PCR), detects polymorphism
- UniSTS:142773

D9Mgc4 (e-PCR), detects polymorphism
- UniSTS:142781

D9Mgc5 (e-PCR), detects polymorphism
- UniSTS:142791

D9Mgc6 (e-PCR), detects polymorphism
- UniSTS:142792

D9Mgc7 (e-PCR), detects polymorphism
- UniSTS:142793

D9Mgc8 (e-PCR), detects polymorphism
- UniSTS:142794

D9Mgc9 (e-PCR), detects polymorphism
- UniSTS:142795

Ephb1 (e-PCR), detects polymorphism
- UniSTS:266991

AW488255 (e-PCR)
- UniSTS:179959

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables axon guidance receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables ephrin receptor activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables transmembrane-ephrin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane-ephrin receptor activity	ISO Inferred from Sequence Orthology more info
enables transmembrane-ephrin receptor activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within axon guidance	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within camera-type eye morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cell-substrate adhesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within central nervous system projection neuron axonogenesis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within central nervous system projection neuron axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cranial nerve development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dendritic spine development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within dendritic spine development	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within dendritic spine morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dendritic spine morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in detection of temperature stimulus involved in sensory perception of pain	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ephrin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within ephrin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in ephrin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in establishment of cell polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hindbrain tangential cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within immunological synapse formation	ISO Inferred from Sequence Orthology more info	PubMed
involved_in modulation of chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in modulation of chemical synaptic transmission	IEP Inferred from Expression Pattern more info	PubMed
involved_in modulation of chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of satellite cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of skeletal muscle satellite cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
involved_in neural precursor cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neurogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within optic nerve morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of synapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within retinal ganglion cell axon guidance	IDA Inferred from Direct Assay more info	PubMed
involved_in skeletal muscle satellite cell activation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in early endosome membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in filopodium tip	IDA Inferred from Direct Assay more info	PubMed
located_in glutamatergic synapse	IC Inferred by Curator more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IEP Inferred from Expression Pattern more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane raft	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: ephrin type-B receptor 1

NP_001161768.1

EC 2.7.10.1

NP_775623.3

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001168296.1 → NP_001161768.1 ephrin type-B receptor 1 isoform 2 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks a coding exon compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.

Source sequence(s)

AK036211, AK039530, BC057301, CT025594

Consensus CDS

CCDS52901.1

UniProtKB/Swiss-Prot

Q8CBF3

UniProtKB/TrEMBL

Q8CA63

Related

ENSMUSP00000082261.6, ENSMUST00000085169.12

Conserved Domains (7) summary

cd05065
Location:585 → 841

PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors

cd09551
Location:867 → 934

SAM_EPH-B1; SAM domain of EPH-B1 subfamily of tyrosine kinase receptors

smart00454
Location:867 → 932

SAM; Sterile alpha motif

cd10476
Location:20 → 195

EphR_LBD_B1; Ligand Binding Domain of Ephrin type-B Receptor 1

cd00063
Location:323 → 429

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:435 → 518

fn3; Fibronectin type III domain

pfam07714
Location:585 → 837

Pkinase_Tyr; Protein tyrosine kinase
NM_173447.3 → NP_775623.3 ephrin type-B receptor 1 isoform 1 precursor

See identical proteins and their annotated locations for NP_775623.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AK036148, AK039530, BC057301

Consensus CDS

CCDS40742.1

UniProtKB/Swiss-Prot

B1B1C2, Q3UY27, Q6PG23, Q8CBE2, Q8CBF3

Related

ENSMUSP00000035129.8, ENSMUST00000035129.14

Conserved Domains (8) summary

cd05065
Location:614 → 882

PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors

cd09551
Location:908 → 975

SAM_EPH-B1; SAM domain of EPH-B1 subfamily of tyrosine kinase receptors

smart00454
Location:908 → 973

SAM; Sterile alpha motif

cd10476
Location:20 → 195

EphR_LBD_B1; Ligand Binding Domain of Ephrin type-B Receptor 1

cd00063
Location:323 → 429

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:435 → 518

fn3; Fibronectin type III domain

pfam07714
Location:619 → 878

Pkinase_Tyr; Protein tyrosine kinase

pfam14575
Location:546 → 614

EphA2_TM; Ephrin type-A receptor 2 transmembrane domain