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Nlrx1 NLR family member X1 [ Mus musculus (house mouse) ]

Gene ID: 270151, updated on 5-Mar-2024

Summary

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Official Symbol
Nlrx1provided by MGI
Official Full Name
NLR family member X1provided by MGI
Primary source
MGI:MGI:2429611
See related
Ensembl:ENSMUSG00000032109 AllianceGenome:MGI:2429611
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NOD9
Summary
Predicted to enable ATP binding activity. Acts upstream of or within negative regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of cytokine production; and negative regulation of defense response. Located in mitochondrion. Orthologous to human NLRX1 (NLR family member X1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in colon adult (RPKM 11.8), adrenal adult (RPKM 10.3) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 A5.2; 9 24.84 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (44164010..44179896, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (44252713..44268599, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 153 Neighboring gene NHERF family PDZ scaffold protein 4 Neighboring gene ATP binding cassette subfamily G member 4 Neighboring gene histone H4 transcription factor Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:44113766-44114058

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mechanism of NLRX1 Mediating JNK Apoptosis Pathway to Participate in Functional Impairment of Cochlear Hair Cells in Mice with Senile Deafness. Yang X, et al. Cell Mol Biol (Noisy-le-grand), 2022 Sep 30. PMID 37114263
  2. NLRX1 knockdown attenuates pro-apoptotic signaling and cell death in pulmonary hyperoxic acute injury. Kim HR, et al. Sci Rep, 2023 Mar 1. PMID 36859435, Free PMC Article
  3. Mitochondrial protein import stress regulates the LC3 lipidation step of mitophagy through NLRX1 and RRBP1. Killackey SA, et al. Mol Cell, 2022 Aug 4. PMID 35752171
  4. Sex-Biased Control of Inflammation and Metabolism by a Mitochondrial Nod-Like Receptor. Snäkä T, et al. Front Immunol, 2022. PMID 35651602, Free PMC Article
  5. Nucleotide-binding domain and leucine-rich-repeat-containing protein X1 deficiency induces nicotinamide adenine dinucleotide decline, mechanistic target of rapamycin activation, and cellular senescence and accelerates aging lung-like changes. Shin HJ, et al. Aging Cell, 2021 Jul. PMID 34087956, Free PMC Article

See all (59) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NLRX1 Prevents M2 Macrophage Polarization and Excessive Renal Fibrosis in Chronic Obstructive Nephropathy.
    Title: NLRX1 Prevents M2 Macrophage Polarization and Excessive Renal Fibrosis in Chronic Obstructive Nephropathy.
  2. Cellular Context Dictates the Suppression or Augmentation of Triple-Negative Mammary Tumor Metastasis by NLRX1.
    Title: Cellular Context Dictates the Suppression or Augmentation of Triple-Negative Mammary Tumor Metastasis by NLRX1.
  3. Mitochondria-ER cooperation: NLRX1 detects mitochondrial protein import stress and promotes mitophagy through the ER protein RRBP1.
    Title: Mitochondria-ER cooperation: NLRX1 detects mitochondrial protein import stress and promotes mitophagy through the ER protein RRBP1.
  4. Mechanism of NLRX1 Mediating JNK Apoptosis Pathway to Participate in Functional Impairment of Cochlear Hair Cells in Mice with Senile Deafness.
    Title: Mechanism of NLRX1 Mediating JNK Apoptosis Pathway to Participate in Functional Impairment of Cochlear Hair Cells in Mice with Senile Deafness.
  5. NLRX1 knockdown attenuates pro-apoptotic signaling and cell death in pulmonary hyperoxic acute injury.
    Title: NLRX1 knockdown attenuates pro-apoptotic signaling and cell death in pulmonary hyperoxic acute injury.
  6. Long noncoding RNA NKILA transferred by astrocyte-derived extracellular vesicles protects against neuronal injury by upregulating NLRX1 through binding to mir-195 in traumatic brain injury.
    Title: Long noncoding RNA NKILA transferred by astrocyte-derived extracellular vesicles protects against neuronal injury by upregulating NLRX1 through binding to mir-195 in traumatic brain injury.
  7. NLRX1 knockout aggravates lipopolysaccharide (LPS)-induced heart injury and attenuates the anti-LPS cardioprotective effect of CYP2J2/11,12-EET by enhancing activation of NF-kappaB and NLRP3 inflammasome.
    Title: NLRX1 knockout aggravates lipopolysaccharide (LPS)-induced heart injury and attenuates the anti-LPS cardioprotective effect of CYP2J2/11,12-EET by enhancing activation of NF-κB and NLRP3 inflammasome.
  8. HPV16 drives cancer immune escape via NLRX1-mediated degradation of STING.
    Title: HPV16 drives cancer immune escape via NLRX1-mediated degradation of STING.
  9. NLRX1 is a key regulator of immune signaling during invasive pulmonary aspergillosis.
    Title: NLRX1 is a key regulator of immune signaling during invasive pulmonary aspergillosis.
  10. important in controlling the early stages of CNS inflammation and preventing the onset of spontaneous autoimmunity
    Title: NLRX1 inhibits the early stages of CNS inflammation and prevents the onset of spontaneous autoimmunity.
Submit: New GeneRIF Correction See all GeneRIFs (39)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (6)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Potential readthrough

Included gene: Nherf4

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of interferon-beta production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of interleukin-6 production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of macrophage cytokine production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of RIG-I signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of canonical NF-kappaB signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of canonical NF-kappaB signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of innate immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of interferon-beta production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of interleukin-6 production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of macrophage cytokine production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
NLR family member X1
Names
nucleotide-binding domain and leucine-rich repeat containing

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163742.1 → NP_001157214.1  NLR family member X1

    See identical proteins and their annotated locations for NP_001157214.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AK166689, BC035045, BY196718
    Consensus CDS
    CCDS23100.1
    UniProtKB/Swiss-Prot
    Q3TL44, Q3UKJ1, Q80W30, Q8C249
    Related
    ENSMUSP00000127531.2, ENSMUST00000168499.9
    Conserved Domains (3) summary
    cd00116
    Location:698 → 903
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:698 → 726
    LRR_RI; leucine-rich repeat [structural motif]
    cl21455
    Location:161 → 320
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. NM_001163743.1 → NP_001157215.1  NLR family member X1

    See identical proteins and their annotated locations for NP_001157215.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC124577, BC035045
    Consensus CDS
    CCDS23100.1
    UniProtKB/Swiss-Prot
    Q3TL44, Q3UKJ1, Q80W30, Q8C249
    Related
    ENSMUSP00000126555.2, ENSMUST00000169651.3
    Conserved Domains (3) summary
    cd00116
    Location:698 → 903
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:698 → 726
    LRR_RI; leucine-rich repeat [structural motif]
    cl21455
    Location:161 → 320
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  3. NM_178420.3 → NP_848507.2  NLR family member X1

    See identical proteins and their annotated locations for NP_848507.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC124577, AK145988, BC035045
    Consensus CDS
    CCDS23100.1
    UniProtKB/Swiss-Prot
    Q3TL44, Q3UKJ1, Q80W30, Q8C249
    Related
    ENSMUSP00000034621.9, ENSMUST00000034621.16
    Conserved Domains (3) summary
    cd00116
    Location:698 → 903
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:698 → 726
    LRR_RI; leucine-rich repeat [structural motif]
    cl21455
    Location:161 → 320
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    44164010..44179896 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3TL44.1 GenPept UniProtKB/Swiss-Prot:Q3TL44

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