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Maml2 mastermind like transcriptional coactivator 2 [ Mus musculus (house mouse) ]

Gene ID: 270118, updated on 11-Apr-2024

Summary

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Official Symbol
Maml2provided by MGI
Official Full Name
mastermind like transcriptional coactivator 2provided by MGI
Primary source
MGI:MGI:2389460
See related
Ensembl:ENSMUSG00000031925 AllianceGenome:MGI:2389460
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
5930431H10
Summary
Predicted to enable transcription coactivator activity. Predicted to be involved in positive regulation of transcription of Notch receptor target. Predicted to be located in nucleus. Predicted to be active in nucleoplasm. Is expressed in neural tube. Orthologous to human MAML2 (mastermind like transcriptional coactivator 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 6.5), bladder adult (RPKM 5.7) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Maml2 in Genome Data Viewer
Location:
9 A1; 9 3.33 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (13296547..13620829)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (13296561..13709533)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 82 Neighboring gene Jrk-like Neighboring gene predicted gene, 26189 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:13269708-13269915 Neighboring gene per-hexamer repeat gene 4 Neighboring gene STARR-seq mESC enhancer starr_23332 Neighboring gene STARR-seq mESC enhancer starr_23333 Neighboring gene STARR-seq mESC enhancer starr_23334 Neighboring gene STARR-seq mESC enhancer starr_23335 Neighboring gene predicted gene, 51666 Neighboring gene VISTA enhancer mm1371 Neighboring gene predicted gene, 39291 Neighboring gene predicted gene, 53498 Neighboring gene myotubularin related protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors. Wu L, et al. Mol Cell Biol, 2002 Nov. PMID 12370315, Free PMC Article
  2. Mastermind-like 1 (MamL1) and mastermind-like 3 (MamL3) are essential for Notch signaling in vivo. Oyama T, et al. Development, 2011 Dec. PMID 22069191
  3. The candidate splicing factor Sfswap regulates growth and patterning of inner ear sensory organs. Moayedi Y, et al. PLoS Genet, 2014 Jan. PMID 24391519, Free PMC Article
  4. Mind bomb 1 is essential for generating functional Notch ligands to activate Notch. Koo BK, et al. Development, 2005 Aug. PMID 16000382
  5. Assembly, verification, and initial annotation of the NIA mouse 7.4K cDNA clone set. VanBuren V, et al. Genome Res, 2002 Dec. PMID 12466305, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC60867

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription coactivator activity ISA
Inferred from Sequence Alignment
more info
 PubMed 
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISA
Inferred from Sequence Alignment
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription of Notch receptor target IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISA
Inferred from Sequence Alignment
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mastermind-like protein 2
Names
mastermind like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013813.5 → NP_001013835.2  mastermind-like protein 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC155923, AC169127, MH423685
    Consensus CDS
    CCDS90496.1
    UniProtKB/TrEMBL
    F6U238
    Related
    ENSMUSP00000124083.3, ENSMUST00000159294.9
    Conserved Domains (1) summary
    pfam09596
    Location:33 → 88
    MamL-1; MamL-1 domain

  2. NM_001410635.1 → NP_001397564.1  mastermind-like protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC155923, AC169127, MH423685

  3. NM_173776.4 → NP_776137.2  mastermind-like protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC155923, AC169127
    Consensus CDS
    CCDS52723.1
    UniProtKB/TrEMBL
    E9Q7L5, Q8BMG4
    Related
    ENSMUSP00000136866.2, ENSMUST00000177755.3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    13296547..13620829
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155025.1 → XP_036010918.1  mastermind-like protein 2 isoform X2

  2. XM_036155024.1 → XP_036010917.1  mastermind-like protein 2 isoform X2

  3. XM_030244398.2 → XP_030100258.1  mastermind-like protein 2 isoform X3

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001013819.1: Suppressed sequence

    Description
    NM_001013819.1: This RefSeq was temporarily suppressed because the CDS was partial.
Nucleotide Protein Strain
Heading Accession and Version

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