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Ogfod1 2-oxoglutarate and iron-dependent oxygenase domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 270086, updated on 11-Apr-2024

Summary

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Official Symbol
Ogfod1provided by MGI
Official Full Name
2-oxoglutarate and iron-dependent oxygenase domain containing 1provided by MGI
Primary source
MGI:MGI:2442978
See related
Ensembl:ENSMUSG00000033009 AllianceGenome:MGI:2442978
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1612; 4930415J21Rik
Summary
Predicted to enable peptidyl-proline 3-dioxygenase activity. Predicted to be involved in several processes, including peptidyl-proline hydroxylation; regulation of translational termination; and stress granule assembly. Predicted to be located in cytoplasmic stress granule; cytosol; and nucleoplasm. Predicted to be active in cytoplasm. Orthologous to human OGFOD1 (2-oxoglutarate and iron dependent oxygenase domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cortex adult (RPKM 13.3), frontal lobe adult (RPKM 11.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ogfod1 in Genome Data Viewer
Location:
8 C5; 8 46.08 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (94763782..94794550)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (94037122..94067922)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene autocrine motility factor receptor Neighboring gene nudix hydrolase 21 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:96561142-96561251 Neighboring gene Bardet-Biedl syndrome 2 Neighboring gene predicted gene, 39226

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Ogfod1 deletion increases cardiac beta-alanine levels and protects mice against ischaemia- reperfusion injury. Harris M, et al. Cardiovasc Res, 2022 Oct 21. PMID 34668514, Free PMC Article
  2. OGFOD1 modulates the transcriptional and proteomic landscapes to alter isoproterenol-induced hypertrophy susceptibility. Rodriguez R, et al. J Mol Cell Cardiol, 2023 Jun. PMID 37084634,
  3. OGFOD1 catalyzes prolyl hydroxylation of RPS23 and is involved in translation control and stress granule formation. Singleton RS, et al. Proc Natl Acad Sci U S A, 2014 Mar 18. PMID 24550447, Free PMC Article
  4. An E3 ubiquitin ligase, Really Interesting New Gene (RING) Finger 41, is a candidate gene for anxiety-like behavior and beta-carboline-induced seizures. Kim S, et al. Biol Psychiatry, 2009 Mar 1. PMID 18986647, Free PMC Article
  5. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. OGFOD1 modulates the transcriptional and proteomic landscapes to alter isoproterenol-induced hypertrophy susceptibility.
    Title: OGFOD1 modulates the transcriptional and proteomic landscapes to alter isoproterenol-induced hypertrophy susceptibility.
  2. Ogfod1 deletion increases cardiac beta-alanine levels and protects mice against ischaemia- reperfusion injury.
    Title: Ogfod1 deletion increases cardiac beta-alanine levels and protects mice against ischaemia- reperfusion injury.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 2-oxoglutarate-dependent dioxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables L-ascorbic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables dioxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
  
enables peptidyl-proline 3-dioxygenase activity ISO
Inferred from Sequence Orthology
more info
  
enables peptidyl-proline dioxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptidyl-proline dioxygenase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-proline hydroxylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-proline hydroxylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein hydroxylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of translational termination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of translational termination ISO
Inferred from Sequence Orthology
more info
  
involved_in stress granule assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic stress granule ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
prolyl 3-hydroxylase OGFOD1
Names
2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1
uS12 prolyl 3-hydroxylase
NP_001087226.1
NP_808435.3
XP_006531116.1
XP_006531117.1
XP_036009973.1
XP_036009974.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001093757.2 → NP_001087226.1  prolyl 3-hydroxylase OGFOD1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC138118
    Consensus CDS
    CCDS52636.1
    UniProtKB/TrEMBL
    D3YTU2
    Related
    ENSMUSP00000090991.3, ENSMUST00000093301.9
    Conserved Domains (1) summary
    cl21496
    Location:221 → 498
    2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily

  2. NM_001428379.1 → NP_001415308.1  prolyl 3-hydroxylase OGFOD1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC138118

  3. NM_001428381.1 → NP_001415310.1  prolyl 3-hydroxylase OGFOD1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC138118

  4. NM_001428382.1 → NP_001415311.1  prolyl 3-hydroxylase OGFOD1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC138118

  5. NM_001428383.1 → NP_001415312.1  prolyl 3-hydroxylase OGFOD1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC138118

  6. NM_001428384.1 → NP_001415313.1  prolyl 3-hydroxylase OGFOD1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC138118

  7. NM_001428385.1 → NP_001415314.1  prolyl 3-hydroxylase OGFOD1 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC138118

  8. NM_001428386.1 → NP_001415315.1  prolyl 3-hydroxylase OGFOD1 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC138118

  9. NM_001428387.1 → NP_001415316.1  prolyl 3-hydroxylase OGFOD1 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC138118

  10. NM_001428388.1 → NP_001415317.1  prolyl 3-hydroxylase OGFOD1 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC138118

  11. NM_001428389.1 → NP_001415318.1  prolyl 3-hydroxylase OGFOD1 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC138118

  12. NM_001428390.1 → NP_001415319.1  prolyl 3-hydroxylase OGFOD1 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AC138118

  13. NM_177767.5 → NP_808435.3  prolyl 3-hydroxylase OGFOD1 isoform 1

    See identical proteins and their annotated locations for NP_808435.3

    Status: VALIDATED

    Source sequence(s)
    AC138118
    Consensus CDS
    CCDS22535.2
    UniProtKB/Swiss-Prot
    Q3TLS5, Q3TPR4, Q3U0K8, Q80TB3, Q8CFR6
    UniProtKB/TrEMBL
    D3YTU2
    Related
    ENSMUSP00000105183.3, ENSMUST00000109556.9
    Conserved Domains (2) summary
    smart00702
    Location:72 → 237
    P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
    cl21496
    Location:262 → 541
    2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily

RNA

  1. NR_190337.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC138118

  2. NR_190338.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC138118

  3. NR_190340.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC138118

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    94763782..94794550
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006531054.5 → XP_006531117.1  prolyl 3-hydroxylase OGFOD1 isoform X3

    Conserved Domains (2) summary
    pfam13661
    Location:42 → 138
    2OG-FeII_Oxy_4; 2OG-Fe(II) oxygenase superfamily
    cl21496
    Location:162 → 446
    2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily

  2. XM_006531053.5 → XP_006531116.1  prolyl 3-hydroxylase OGFOD1 isoform X1

    Conserved Domains (2) summary
    pfam13661
    Location:84 → 180
    2OG-FeII_Oxy_4; 2OG-Fe(II) oxygenase superfamily
    cl21496
    Location:204 → 488
    2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily

  3. XM_036154080.1 → XP_036009973.1  prolyl 3-hydroxylase OGFOD1 isoform X2

    Conserved Domains (2) summary
    pfam13661
    Location:45 → 141
    2OG-FeII_Oxy_4; 2OG-Fe(II) oxygenase superfamily
    cl21496
    Location:165 → 449
    2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily

  4. XM_036154081.1 → XP_036009974.1  prolyl 3-hydroxylase OGFOD1 isoform X2

    UniProtKB/TrEMBL
    D3YTU2
    Conserved Domains (2) summary
    pfam13661
    Location:45 → 141
    2OG-FeII_Oxy_4; 2OG-Fe(II) oxygenase superfamily
    cl21496
    Location:165 → 449
    2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3U0K8.1 GenPept UniProtKB/Swiss-Prot:Q3U0K8

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