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Micall1 microtubule associated monooxygenase, calponin and LIM domain containing -like 1 [ Mus musculus (house mouse) ]

Gene ID: 27008, updated on 5-Mar-2024

Summary

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Official Symbol
Micall1provided by MGI
Official Full Name
microtubule associated monooxygenase, calponin and LIM domain containing -like 1provided by MGI
Primary source
MGI:MGI:105870
See related
Ensembl:ENSMUSG00000033039 AllianceGenome:MGI:105870
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D15N2e; MIRab13; D15Mit260; EST573322; EST820961; mKIAA1668
Summary
Enables small GTPase binding activity. Involved in neuron projection development. Predicted to be located in endosome membrane and late endosome. Predicted to be extrinsic component of membrane. Is expressed in bladder; midgut; and pharyngo-tympanic tube. Orthologous to human MICALL1 (MICAL like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 29.6), testis adult (RPKM 25.5) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Micall1 in Genome Data Viewer
Location:
15 E1; 15 37.7 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (78992750..79021100)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (79108550..79136900)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 54 Neighboring gene STARR-positive B cell enhancer ABC_E1482 Neighboring gene STARR-seq mESC enhancer starr_39166 Neighboring gene eukaryotic translation initiation factor 3, subunit L Neighboring gene RIKEN cDNA 1700088E04 gene Neighboring gene STARR-positive B cell enhancer ABC_E7388 Neighboring gene polymerase (RNA) II (DNA directed) polypeptide F Neighboring gene D6 enhancer downstream of Sox10 Neighboring gene MCS1C/MCS2 enhancer region 5' of Sox10 Neighboring gene SRY (sex determining region Y)-box 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Rab35 establishes the EHD1-association site by coordinating two distinct effectors during neurite outgrowth. Kobayashi H, et al. J Cell Sci, 2013 Jun 1. PMID 23572513
  2. The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions. Yamamura R, et al. Mol Biol Cell, 2008 Mar. PMID 18094055, Free PMC Article
  3. EHBP1L1 coordinates Rab8 and Bin1 to regulate apical-directed transport in polarized epithelial cells. Nakajo A, et al. J Cell Biol, 2016 Feb 1. PMID 26833786, Free PMC Article
  4. The COMPASS Family Protein ASH2L Mediates Corticogenesis via Transcriptional Regulation of Wnt Signaling. Li L, et al. Cell Rep, 2019 Jul 16. PMID 31315048
  5. CIN85 interacting proteins in B cells-specific role for SHIP-1. Büchse T, et al. Mol Cell Proteomics, 2011 Oct. PMID 21725061, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidic acid binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cellular response to nerve growth factor stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in endocytic recycling ISO
Inferred from Sequence Orthology
more info
  
involved_in endocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron projection development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron projection development ISO
Inferred from Sequence Orthology
more info
  
involved_in plasma membrane tubulation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to endosome ISO
Inferred from Sequence Orthology
more info
  
involved_in protein targeting to membrane ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in receptor-mediated endocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in slow endocytic recycling ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasmic side of endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in late endosome ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
MICAL-like protein 1
Names
microtubule associated monoxygenase, calponin and LIM domain containing -like 1
molecule interacting with Rab13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177461.2 → NP_803412.1  MICAL-like protein 1

    See identical proteins and their annotated locations for NP_803412.1

    Status: VALIDATED

    Source sequence(s)
    AL589670
    Consensus CDS
    CCDS49667.1
    UniProtKB/Swiss-Prot
    E9QKJ4, Q8BGT6, Q8BJ60
    Related
    ENSMUSP00000042053.9, ENSMUST00000040320.10
    Conserved Domains (4) summary
    cd09444
    Location:165 → 219
    LIM_Mical_like_1; This domain belongs to the LIM domain family which are found on Mical (molecule interacting with CasL) like proteins
    PHA03247
    Location:268 → 669
    PHA03247; large tegument protein UL36; Provisional
    cd21252
    Location:4 → 110
    CH_MICALL1; calponin homology (CH) domain found in MICAL-like protein 1
    pfam12130
    Location:691 → 815
    DUF3585; Protein of unknown function (DUF3585)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    78992750..79021100
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159443.1 → XP_036015336.1  MICAL-like protein 1 isoform X2

    Conserved Domains (4) summary
    cd09444
    Location:137 → 191
    LIM_Mical_like_1; This domain belongs to the LIM domain family which are found on Mical (molecule interacting with CasL) like proteins
    PHA03247
    Location:259 → 658
    PHA03247; large tegument protein UL36; Provisional
    pfam12130
    Location:680 → 802
    DUF3585; Protein of unknown function (DUF3585)
    cl00030
    Location:22 → 82
    CH_SF; calponin homology (CH) domain superfamily

  2. XM_036159442.1 → XP_036015335.1  MICAL-like protein 1 isoform X1

    Conserved Domains (4) summary
    cd09444
    Location:165 → 219
    LIM_Mical_like_1; This domain belongs to the LIM domain family which are found on Mical (molecule interacting with CasL) like proteins
    PHA03247
    Location:287 → 686
    PHA03247; large tegument protein UL36; Provisional
    pfam12130
    Location:708 → 830
    DUF3585; Protein of unknown function (DUF3585)
    cd21252
    Location:4 → 110
    CH_MICALL1; calponin homology (CH) domain found in MICAL-like protein 1

  3. XM_036159444.1 → XP_036015337.1  MICAL-like protein 1 isoform X3

    Conserved Domains (3) summary
    cd09444
    Location:36 → 90
    LIM_Mical_like_1; This domain belongs to the LIM domain family which are found on Mical (molecule interacting with CasL) like proteins
    PHA03247
    Location:158 → 557
    PHA03247; large tegument protein UL36; Provisional
    pfam12130
    Location:579 → 701
    DUF3585; Protein of unknown function (DUF3585)

  4. XM_006521024.2 → XP_006521087.1  MICAL-like protein 1 isoform X4

    See identical proteins and their annotated locations for XP_006521087.1

    UniProtKB/Swiss-Prot
    Q8BGT6
    Conserved Domains (2) summary
    PHA03247
    Location:108 → 312
    PHA03247; large tegument protein UL36; Provisional
    pfam12130
    Location:334 → 458
    DUF3585; Protein of unknown function (DUF3585)

RNA

  1. XR_004938842.1 RNA Sequence

    Related
    ENSMUST00000229031.2
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BGT6.3 GenPept UniProtKB/Swiss-Prot:Q8BGT6

Gene LinkOut

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