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Nalf1 NALCN channel auxiliary factor 1 [ Mus musculus (house mouse) ]

Gene ID: 270028, updated on 5-Mar-2024

Summary

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Official Symbol
Nalf1provided by MGI
Official Full Name
NALCN channel auxiliary factor 1provided by MGI
Primary source
MGI:MGI:2142765
See related
Ensembl:ENSMUSG00000079157 AllianceGenome:MGI:2142765
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tmem28; Fam155a; 6430500D16
Summary
Predicted to contribute to stretch-activated, cation-selective, calcium channel activity. Predicted to be involved in calcium ion import across plasma membrane. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including central nervous system and retina nuclear layer. Orthologous to human NALF1 (NALCN channel auxiliary factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in frontal lobe adult (RPKM 4.6), cortex adult (RPKM 3.9) and 7 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 A1.1; 8 3.9 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (9256006..9823329, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (9206006..9773329, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930453L07 gene Neighboring gene STARR-seq mESC enhancer starr_20682 Neighboring gene predicted gene, 31726 Neighboring gene predicted gene, 39128 Neighboring gene STARR-seq mESC enhancer starr_20686 Neighboring gene STARR-seq mESC enhancer starr_20687 Neighboring gene STARR-seq mESC enhancer starr_20688 Neighboring gene STARR-seq mESC enhancer starr_20691 Neighboring gene STARR-seq mESC enhancer starr_20692 Neighboring gene STARR-seq mESC enhancer starr_20693 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:9912234-9912417 Neighboring gene STARR-seq mESC enhancer starr_20694 Neighboring gene STARR-positive B cell enhancer ABC_E8225 Neighboring gene STARR-positive B cell enhancer ABC_E10489 Neighboring gene abhydrolase domain containing 13 Neighboring gene ligase IV, DNA, ATP-dependent

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Structure of voltage-modulated sodium-selective NALCN-FAM155A channel complex. Kang Y, et al. Nat Commun, 2020 Dec 3. PMID 33273469, Free PMC Article
  2. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
  3. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structure of voltage-modulated sodium-selective NALCN-FAM155A channel complex.
    Title: Structure of voltage-modulated sodium-selective NALCN-FAM155A channel complex.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to stretch-activated, monoatomic cation-selective, calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in calcium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
NALCN channel auxiliary factor 1
Names
family with sequence similarity 155, member A
transmembrane protein 28
transmembrane protein FAM155A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347127.1 → NP_001334056.1  NALCN channel auxiliary factor 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes an alternate exon which results in a different 3' coding region and UTR, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC099760, AK032202, AW121567, BC117535
    Consensus CDS
    CCDS85497.1
    UniProtKB/Swiss-Prot
    Q8CCS2
    Related
    ENSMUSP00000146609.2, ENSMUST00000208933.2
    Conserved Domains (1) summary
    pfam12929
    Location:278 → 323
    Mid1; Stretch-activated Ca2+-permeable channel component

  2. NM_173446.2 → NP_775622.1  NALCN channel auxiliary factor 1 isoform 1

    See identical proteins and their annotated locations for NP_775622.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC099760, AC107823
    Consensus CDS
    CCDS40216.1
    UniProtKB/Swiss-Prot
    Q149R3, Q8CCS2
    Related
    ENSMUSP00000106596.4, ENSMUST00000110969.5
    Conserved Domains (1) summary
    pfam12929
    Location:278 → 323
    Mid1; Stretch-activated Ca2+-permeable channel component

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    9256006..9823329 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011242064.3 → XP_011240366.1  NALCN channel auxiliary factor 1 isoform X1

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CCS2.1 GenPept UniProtKB/Swiss-Prot:Q8CCS2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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