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Adamtsl3 ADAMTS-like 3 [ Mus musculus (house mouse) ]

Gene ID: 269959, updated on 5-Mar-2024

Summary

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Official Symbol
Adamtsl3provided by MGI
Official Full Name
ADAMTS-like 3provided by MGI
Primary source
MGI:MGI:3028499
See related
Ensembl:ENSMUSG00000070469 AllianceGenome:MGI:3028499
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1233; C130057K09; 9230119C12Rik
Summary
Predicted to be involved in extracellular matrix organization. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be active in extracellular matrix. Orthologous to human ADAMTSL3 (ADAMTS like 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in bladder adult (RPKM 4.3), limb E14.5 (RPKM 2.6) and 13 other tissues See more
Orthologs
human all
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Genomic context

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See Adamtsl3 in Genome Data Viewer
Location:
7 D3; 7 47.18 cM
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (81984612..82263658)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (82335399..82614450)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene SH3-domain GRB2-like 3 Neighboring gene STARR-seq mESC enhancer starr_19382 Neighboring gene STARR-seq mESC enhancer starr_19384 Neighboring gene predicted gene, 32903 Neighboring gene predicted gene, 51492 Neighboring gene stabilizer of axonemal microtubules 2 Neighboring gene VISTA enhancer mm1514 Neighboring gene elongation factor like GTPase 1 Neighboring gene RIKEN cDNA 4933406J10 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ADAMTSL3 knock-out mice develop cardiac dysfunction and dilatation with increased TGFβ signalling after pressure overload. Rypdal KB, et al. Commun Biol, 2022 Dec 20. PMID 36539599, Free PMC Article
  2. ADAMTSL-3/punctin-2, a novel glycoprotein in extracellular matrix related to the ADAMTS family of metalloproteases. Hall NG, et al. Matrix Biol, 2003 Nov. PMID 14667842
  3. O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation. Du J, et al. Dev Biol, 2010 Oct 1. PMID 20637190, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ADAMTSL3 knock-out mice develop cardiac dysfunction and dilatation with increased TGFbeta signalling after pressure overload.
    Title: ADAMTSL3 knock-out mice develop cardiac dysfunction and dilatation with increased TGFβ signalling after pressure overload.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Clone Names

  • KIAA1233

Gene Ontology Provided by MGI

Component Evidence Code Pubs
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ADAMTS-like protein 3
Names
a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif like, 3
punctin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001190374.1 → NP_001177303.1  ADAMTS-like protein 3

    Status: PROVISIONAL

    Source sequence(s)
    AC110192, AC138270
    Consensus CDS
    CCDS57559.1
    UniProtKB/TrEMBL
    G3UXC7
    Related
    ENSMUSP00000133637.2, ENSMUST00000173287.8
    Conserved Domains (6) summary
    smart00408
    Location:1330 → 1388
    IGc2; Immunoglobulin C-2 Type
    smart00209
    Location:90 → 136
    TSP1; Thrombospondin type 1 repeats
    smart00410
    Location:1321 → 1393
    IG_like; Immunoglobulin like
    pfam08686
    Location:1674 → 1704
    PLAC; PLAC (protease and lacunin) domain
    cl11960
    Location:942 → 1006
    Ig; Immunoglobulin domain
    cl15278
    Location:1503 → 1558
    TSP_1; Thrombospondin type 1 domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    81984612..82263658
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006507893.4 → XP_006507956.1  ADAMTS-like protein 3 isoform X2

    Conserved Domains (4) summary
    smart00209
    Location:90 → 136
    TSP1; Thrombospondin type 1 repeats
    cd00096
    Location:1331 → 1393
    Ig; Immunoglobulin domain
    cl11960
    Location:942 → 1006
    Ig; Immunoglobulin domain
    cl15278
    Location:1503 → 1558
    TSP_1; Thrombospondin type 1 domain

  2. XM_036153144.1 → XP_036009037.1  ADAMTS-like protein 3 isoform X1

  3. XM_006507894.4 → XP_006507957.1  ADAMTS-like protein 3 isoform X3

    Conserved Domains (3) summary
    smart00209
    Location:90 → 136
    TSP1; Thrombospondin type 1 repeats
    cd00096
    Location:1224 → 1289
    Ig; Immunoglobulin domain
    cl11960
    Location:942 → 1006
    Ig; Immunoglobulin domain

RNA

  1. XR_378247.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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