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Ttll13 tubulin tyrosine ligase-like family, member 13 [ Mus musculus (house mouse) ]

Gene ID: 269954, updated on 21-Apr-2024

Summary

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Official Symbol
Ttll13provided by MGI
Official Full Name
tubulin tyrosine ligase-like family, member 13provided by MGI
Primary source
MGI:MGI:1920845
See related
Ensembl:ENSMUSG00000045467 AllianceGenome:MGI:1920845
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4921538O11; 1700111A04Rik
Summary
Predicted to enable tubulin binding activity and tubulin-glutamic acid ligase activity. Predicted to be involved in microtubule cytoskeleton organization and protein polyglutamylation. Predicted to be located in microtubule. Predicted to be active in cilium. Orthologous to human TTLL13 (tubulin tyrosine ligase like 13). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 120.2) See more
Orthologs
human all
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Genomic context

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Location:
7 D2; 7 45.57 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (79896101..79910569)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (80246353..80260821)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10446 Neighboring gene calcium and integrin binding 1 Neighboring gene GDP-D-glucose phosphorylase 1 Neighboring gene STARR-positive B cell enhancer ABC_E4940 Neighboring gene neugrin, neurite outgrowth associated Neighboring gene STARR-positive B cell enhancer ABC_E2826 Neighboring gene vacuolar protein sorting 33B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A targeted multienzyme mechanism for selective microtubule polyglutamylation. van Dijk J, et al. Mol Cell, 2007 May 11. PMID 17499049
  2. Klf4 glutamylation is required for cell reprogramming and early embryonic development in mice. Ye B, et al. Nat Commun, 2018 Mar 28. PMID 29593216, Free PMC Article
  3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2) 
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tubulin-glutamic acid ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tubulin-glutamic acid ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein modification process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein polyglutamylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cilium IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
tubulin polyglutamylase TTLL13
Names
tubulin--tyrosine ligase-like protein 13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001396015.1 → NP_001382944.1  tubulin polyglutamylase TTLL13 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC109232
    UniProtKB/TrEMBL
    A6H647
    Related
    ENSMUSP00000145702.2, ENSMUST00000205270.2
    Conserved Domains (1) summary
    pfam03133
    Location:133 → 418
    TTL; Tubulin-tyrosine ligase family

  2. NM_177765.4 → NP_808433.2  tubulin polyglutamylase TTLL13 isoform 2

    See identical proteins and their annotated locations for NP_808433.2

    Status: VALIDATED

    Source sequence(s)
    AC109232
    Consensus CDS
    CCDS39996.1
    UniProtKB/Swiss-Prot
    A4Q9F6, Q8C0W9
    UniProtKB/TrEMBL
    A6H647
    Related
    ENSMUSP00000062795.7, ENSMUST00000058266.9
    Conserved Domains (1) summary
    pfam03133
    Location:133 → 418
    TTL; Tubulin-tyrosine ligase family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    79896101..79910569
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006540925.4 → XP_006540988.2  tubulin polyglutamylase TTLL13 isoform X7

    UniProtKB/TrEMBL
    A6H647
    Conserved Domains (2) summary
    TIGR03185
    Location:383 → 552
    DNA_S_dndD; DNA sulfur modification protein DndD
    pfam03133
    Location:71 → 356
    TTL; Tubulin-tyrosine ligase family

  2. XM_030242619.1 → XP_030098479.1  tubulin polyglutamylase TTLL13 isoform X7

    UniProtKB/TrEMBL
    A6H647
    Conserved Domains (2) summary
    TIGR03185
    Location:383 → 552
    DNA_S_dndD; DNA sulfur modification protein DndD
    pfam03133
    Location:71 → 356
    TTL; Tubulin-tyrosine ligase family

  3. XM_030242621.2 → XP_030098481.1  tubulin polyglutamylase TTLL13 isoform X11

    UniProtKB/TrEMBL
    A6H647
    Conserved Domains (2) summary
    TIGR03185
    Location:340 → 509
    DNA_S_dndD; DNA sulfur modification protein DndD
    pfam03133
    Location:28 → 313
    TTL; Tubulin-tyrosine ligase family

  4. XM_006540914.5 → XP_006540977.1  tubulin polyglutamylase TTLL13 isoform X1

    See identical proteins and their annotated locations for XP_006540977.1

    UniProtKB/TrEMBL
    A6H647
    Conserved Domains (2) summary
    TIGR03185
    Location:466 → 635
    DNA_S_dndD; DNA sulfur modification protein DndD
    pfam03133
    Location:154 → 439
    TTL; Tubulin-tyrosine ligase family

  5. XM_006540915.5 → XP_006540978.1  tubulin polyglutamylase TTLL13 isoform X1

    See identical proteins and their annotated locations for XP_006540978.1

    UniProtKB/TrEMBL
    A6H647
    Conserved Domains (2) summary
    TIGR03185
    Location:466 → 635
    DNA_S_dndD; DNA sulfur modification protein DndD
    pfam03133
    Location:154 → 439
    TTL; Tubulin-tyrosine ligase family

  6. XM_006540913.5 → XP_006540976.1  tubulin polyglutamylase TTLL13 isoform X1

    See identical proteins and their annotated locations for XP_006540976.1

    UniProtKB/TrEMBL
    A6H647
    Conserved Domains (2) summary
    TIGR03185
    Location:466 → 635
    DNA_S_dndD; DNA sulfur modification protein DndD
    pfam03133
    Location:154 → 439
    TTL; Tubulin-tyrosine ligase family

  7. XM_006540918.5 → XP_006540981.1  tubulin polyglutamylase TTLL13 isoform X4

    UniProtKB/TrEMBL
    A6H647
    Conserved Domains (2) summary
    TIGR03185
    Location:466 → 635
    DNA_S_dndD; DNA sulfur modification protein DndD
    pfam03133
    Location:154 → 439
    TTL; Tubulin-tyrosine ligase family

  8. XM_006540920.5 → XP_006540983.1  tubulin polyglutamylase TTLL13 isoform X8

    See identical proteins and their annotated locations for XP_006540983.1

    Conserved Domains (2) summary
    TIGR03185
    Location:466 → 635
    DNA_S_dndD; DNA sulfur modification protein DndD
    pfam03133
    Location:154 → 439
    TTL; Tubulin-tyrosine ligase family

  9. XM_006540921.5 → XP_006540984.1  tubulin polyglutamylase TTLL13 isoform X8

    See identical proteins and their annotated locations for XP_006540984.1

    Conserved Domains (2) summary
    TIGR03185
    Location:466 → 635
    DNA_S_dndD; DNA sulfur modification protein DndD
    pfam03133
    Location:154 → 439
    TTL; Tubulin-tyrosine ligase family

  10. XM_006540916.5 → XP_006540979.1  tubulin polyglutamylase TTLL13 isoform X2

    UniProtKB/TrEMBL
    A6H647
    Conserved Domains (2) summary
    TIGR03185
    Location:466 → 632
    DNA_S_dndD; DNA sulfur modification protein DndD
    pfam03133
    Location:154 → 439
    TTL; Tubulin-tyrosine ligase family

  11. XM_036153142.1 → XP_036009035.1  tubulin polyglutamylase TTLL13 isoform X6

    UniProtKB/TrEMBL
    A6H647
    Conserved Domains (1) summary
    pfam03133
    Location:154 → 439
    TTL; Tubulin-tyrosine ligase family

  12. XM_030242620.2 → XP_030098480.1  tubulin polyglutamylase TTLL13 isoform X9

    Conserved Domains (2) summary
    TIGR03185
    Location:466 → 632
    DNA_S_dndD; DNA sulfur modification protein DndD
    pfam03133
    Location:154 → 439
    TTL; Tubulin-tyrosine ligase family

  13. XM_006540917.5 → XP_006540980.1  tubulin polyglutamylase TTLL13 isoform X3

    UniProtKB/TrEMBL
    A6H647
    Conserved Domains (2) summary
    TIGR03185
    Location:445 → 614
    DNA_S_dndD; DNA sulfur modification protein DndD
    pfam03133
    Location:133 → 418
    TTL; Tubulin-tyrosine ligase family

  14. XM_006540922.5 → XP_006540985.1  tubulin polyglutamylase TTLL13 isoform X10

    UniProtKB/TrEMBL
    A6H647
    Conserved Domains (2) summary
    TIGR03185
    Location:361 → 530
    DNA_S_dndD; DNA sulfur modification protein DndD
    pfam03133
    Location:49 → 334
    TTL; Tubulin-tyrosine ligase family

  15. XM_017322293.3 → XP_017177782.1  tubulin polyglutamylase TTLL13 isoform X11

    UniProtKB/TrEMBL
    A6H647
    Conserved Domains (2) summary
    TIGR03185
    Location:340 → 509
    DNA_S_dndD; DNA sulfur modification protein DndD
    pfam03133
    Location:28 → 313
    TTL; Tubulin-tyrosine ligase family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A4Q9F6.1 GenPept UniProtKB/Swiss-Prot:A4Q9F6

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