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Zfp446 zinc finger protein 446 [ Mus musculus (house mouse) ]

Gene ID: 269870, updated on 3-Apr-2024

Summary

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Official Symbol
Zfp446provided by MGI
Official Full Name
zinc finger protein 446provided by MGI
Primary source
MGI:MGI:2442185
See related
Ensembl:ENSMUSG00000033961 AllianceGenome:MGI:2442185
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A930031C22; A630035I11Rik
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Is expressed in early conceptus; genitourinary system; and limb. Orthologous to human ZNF446 (zinc finger protein 446). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in whole brain E14.5 (RPKM 2.1), CNS E14 (RPKM 2.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 A1; 7 7.71 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (12711726..12718323)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (12976196..12985717)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1810019N24 gene Neighboring gene STARR-seq mESC enhancer starr_18063 Neighboring gene predicted gene 29638 Neighboring gene zinc finger protein 324 Neighboring gene solute carrier family 27 (fatty acid transporter), member 5 Neighboring gene zinc finger and BTB domain containing 45 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:13594963-13595072 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:13595132-13595322 Neighboring gene STARR-positive B cell enhancer ABC_E6511

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
  2. An atlas of combinatorial transcriptional regulation in mouse and man. Ravasi T, et al. Cell, 2010 Mar 5. PMID 20211142, Free PMC Article
  3. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
  4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  5. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 446

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168561.2 → NP_001162033.1  zinc finger protein 446 isoform 2

    See identical proteins and their annotated locations for NP_001162033.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC121301
    Consensus CDS
    CCDS52023.1
    UniProtKB/TrEMBL
    Q149D4
    Related
    ENSMUSP00000104177.2, ENSMUST00000108537.8
    Conserved Domains (4) summary
    smart00431
    Location:22 → 127
    SCAN; leucine rich region
    sd00017
    Location:246 → 266
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:136 → 162
    KRAB; KRAB box
    pfam02023
    Location:22 → 110
    SCAN; SCAN domain

  2. NM_001168562.2 → NP_001162034.1  zinc finger protein 446 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate segment in the 3' portion of the coding sequence compared to variant 1, that causes a frameshift. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC121301
    Consensus CDS
    CCDS52022.1
    UniProtKB/TrEMBL
    E9Q6F9, Q149D5
    Related
    ENSMUSP00000104175.2, ENSMUST00000108535.8
    Conserved Domains (3) summary
    smart00431
    Location:22 → 126
    SCAN; leucine rich region
    pfam01352
    Location:211 → 237
    KRAB; KRAB box
    pfam02023
    Location:22 → 110
    SCAN; SCAN domain

  3. NM_001404125.1 → NP_001391054.1  zinc finger protein 446 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC121301
    UniProtKB/TrEMBL
    G3X9U2
    Related
    ENSMUSP00000104176.2, ENSMUST00000108536.3

  4. NM_001404126.1 → NP_001391055.1  zinc finger protein 446 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC121301

  5. NM_001404127.1 → NP_001391056.1  zinc finger protein 446 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC121301

  6. NM_175558.5 → NP_780767.1  zinc finger protein 446 isoform 1

    See identical proteins and their annotated locations for NP_780767.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC121301
    Consensus CDS
    CCDS20820.1
    UniProtKB/TrEMBL
    Q80Y64, Q8C9M8
    Related
    ENSMUSP00000039073.8, ENSMUST00000045810.15
    Conserved Domains (5) summary
    smart00431
    Location:122 → 226
    SCAN; leucine rich region
    cd07765
    Location:301 → 338
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    smart00355
    Location:468 → 490
    ZnF_C2H2; zinc finger
    sd00017
    Location:421 → 441
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam02023
    Location:122 → 210
    SCAN; SCAN domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    12711726..12718323
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_004934108.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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