Orai2 ORAI calcium release-activated calcium modulator 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Orai2provided by MGI
Official Full Name: ORAI calcium release-activated calcium modulator 2provided by MGI
Primary source: MGI:MGI:2443195
See related: Ensembl:ENSMUSG00000039747 AllianceGenome:MGI:2443195
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tmem142b; A730041O15Rik
Summary: Predicted to enable store-operated calcium channel activity. Predicted to be involved in store-operated calcium entry. Located in membrane. Is expressed in several structures, including foregut; nervous system; nose; skin; and tooth. Orthologous to human ORAI2 (ORAI calcium release-activated calcium modulator 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in thymus adult (RPKM 40.1), spleen adult (RPKM 26.5) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 G2; 5 75.84 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (136176310..136201418, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (136147456..136170697, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Blockade of Platelet Glycoprotein Ibalpha Augments Neuroprotection in Orai2-Deficient Mice during Middle Cerebral Artery Occlusion.
Title: Blockade of Platelet Glycoprotein Ibα Augments Neuroprotection in Orai2-Deficient Mice during Middle Cerebral Artery Occlusion.
Orai2 channel regulates prostaglandin E2 production in TNFalpha/IL1alpha-stimulated astrocytes.
Title: Orai2 channel regulates prostaglandin E(2) production in TNFα/IL1α-stimulated astrocytes.
ORAI1 and ORAI2 modulate murine neutrophil calcium signaling, cellular activation, and host defense.
Title: ORAI1 and ORAI2 modulate murine neutrophil calcium signaling, cellular activation, and host defense.
Calcium signals induced by calcium store depletion or oxygen/glucose deprivation were significantly diminished in Orai2-deficient neurons demonstrating that Orai2 is a central mediator of neuronal capacitative Ca(2+) entry and is involved in calcium overload during ischemia.
Title: Loss of Orai2-Mediated Capacitative Ca(2+) Entry Is Neuroprotective in Acute Ischemic Stroke.
Orai2 proteins contribute to Ca(2+) entry in connective tissue type mast cells in discrete operation modes depending on the availability of calcium ions in the extracellular space.
Title: Deletion of Orai2 augments endogenous CRAC currents and degranulation in mast cells leading to enhanced anaphylaxis.
ORAI1 and ORAI2 form heteromeric Ca(2+) release-activated Ca(2+) channels, in which ORAI2 fine-tunes the magnitude of Store-operated Ca(2+) entry to modulate immune responses.
Title: ORAI2 modulates store-operated calcium entry and T cell-mediated immunity.
This study demonstrated that Transient Receptor Potential Canonical 6 (TRPC6) and Orai2 form stromal interaction molecule 2 (STIM2)-regulated neuronal-store-operated Ca(2+) influx (nSOC) channel complex in hippocampal synapse and the resulting Ca(2+) influx is critical for long-term maintenance of mushroom spines in hippocampal neurons.
Title: Store-Operated Calcium Channel Complex in Postsynaptic Spines: A New Therapeutic Target for Alzheimer's Disease Treatment.
results identified the ORAI-NOX2 feedback loop as a determinant of monocyte immune responses.
Title: A calcium-redox feedback loop controls human monocyte immune responses: The role of ORAI Ca2+ channels.
The data from this study indicate that upregulation of STIM2 and Orai2 is involved in the phenotypic transition of pulmonary arterial smooth muscle cells from a contractile state to a proliferative state.
Title: Upregulated expression of STIM2, TRPC6, and Orai2 contributes to the transition of pulmonary arterial smooth muscle cells from a contractile to proliferative phenotype.
Data indicate that the Ca(2+) release-activated Ca(2+) channels (CRAC) blocker GSK-7975A inhibited store-operated Ca(2+) entry in a concentration-dependent manner.
Title: Ca2+ release-activated Ca2+ channel blockade as a potential tool in antipancreatitis therapy.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (6) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:488557

D5Mit341 (e-PCR), detects polymorphism
- UniSTS:130488

WI-15098 (e-PCR)
- UniSTS:38337

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables store-operated calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables store-operated calcium channel activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in store-operated calcium entry	IBA Inferred from Biological aspect of Ancestor more info
involved_in store-operated calcium entry	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in growth cone	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein orai-2

Names: calcium release-activated calcium channel 2; transmembrane protein 142B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.