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Mphosph9 M-phase phosphoprotein 9 [ Mus musculus (house mouse) ]

Gene ID: 269702, updated on 5-Mar-2024

Summary

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Official Symbol
Mphosph9provided by MGI
Official Full Name
M-phase phosphoprotein 9provided by MGI
Primary source
MGI:MGI:2443138
See related
Ensembl:ENSMUSG00000038126 AllianceGenome:MGI:2443138
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MPP9; MPP-9; 4930548D04Rik; 9630025B04Rik; B930097C17Rik
Summary
Predicted to be located in Golgi apparatus. Predicted to be active in centriole. Is expressed in embryo. Human ortholog(s) of this gene implicated in multiple sclerosis. Orthologous to human MPHOSPH9 (M-phase phosphoprotein 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 4.8), CNS E11.5 (RPKM 4.5) and 24 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 F; 5 63.47 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (124389022..124466001, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (124250959..124329397, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol transfer protein, membrane-associated 2 Neighboring gene phosphatidylinositol transfer protein, membrane-associated 2, opposite strand 2 Neighboring gene STARR-seq mESC enhancer starr_14332 Neighboring gene STARR-positive B cell enhancer ABC_E6381 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:124682259-124682612 Neighboring gene phosphatidylinositol transfer protein, membrane-associated 2, opposite strand 1 Neighboring gene STARR-seq mESC enhancer starr_14333 Neighboring gene mitochondrial translation release factor in rescue Neighboring gene cyclin dependent kinase 2 associated protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. M-Phase Phosphoprotein 9 regulates ciliogenesis by modulating CP110-CEP97 complex localization at the mother centriole. Huang N, et al. Nat Commun, 2018 Oct 30. PMID 30375385, Free PMC Article
  2. A mouse-specific retrotransposon drives a conserved Cdk2ap1 isoform essential for development. Modzelewski AJ, et al. Cell, 2021 Oct 28. PMID 34644528, Free PMC Article
  3. The trafficking protein Tmed2/p24beta(1) is required for morphogenesis of the mouse embryo and placenta. Jerome-Majewska LA, et al. Dev Biol, 2010 May 1. PMID 20178780, Free PMC Article
  4. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001
  5. Exchangeable gene trap using the Cre/mutated lox system. Araki K, et al. Cell Mol Biol (Noisy-le-grand), 1999 Jul. PMID 10512203

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MPP9 acts as a regulator of ciliogenesis by regulating the localization of CP110-CEP97 at the mother centriole.
    Title: M-Phase Phosphoprotein 9 regulates ciliogenesis by modulating CP110-CEP97 complex localization at the mother centriole.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3) 
  • Endonuclease-mediated (1)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in negative regulation of cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cilium assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in centriole IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centriole ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
M-phase phosphoprotein 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081323.3 → NP_001074792.1  M-phase phosphoprotein 9 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a. This variant lacks full-length transcript support; its exon combination is inferred based on aligning partial transcripts.
    Source sequence(s)
    AC127339, AC164421
    Consensus CDS
    CCDS39277.1
    UniProtKB/Swiss-Prot
    A0A8Q0P9S6, A6H5Y1, E9QPF8, Q8BUK7, Q8BV15, V9GX48
    Related
    ENSMUSP00000031344.7, ENSMUST00000031344.13
    Conserved Domains (2) summary
    pfam01442
    Location:521 → 683
    Apolipoprotein; Apolipoprotein A1/A4/E domain
    pfam15035
    Location:550 → 714
    Rootletin; Ciliary rootlet component, centrosome cohesion

  2. NM_001277867.2 → NP_001264796.1  M-phase phosphoprotein 9 isoform a

    See identical proteins and their annotated locations for NP_001264796.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). This variant lacks full-length transcript support; its exon combination is inferred based on aligning partial transcripts and on orthologous alignments.
    Source sequence(s)
    AC127339, AC164421
    Consensus CDS
    CCDS71671.1
    UniProtKB/TrEMBL
    A0A8Q0L6P9
    Related
    ENSMUSP00000138982.2, ENSMUST00000184951.8
    Conserved Domains (1) summary
    COG1196
    Location:556 → 759
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  3. NM_001408187.1 → NP_001395116.1  M-phase phosphoprotein 9 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC127339, AC164421

  4. NM_001408188.1 → NP_001395117.1  M-phase phosphoprotein 9 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC127339, AC164421

RNA

  1. NR_176470.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC127339, AC164421

  2. NR_176471.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC127339, AC164421

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    124389022..124466001 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165156.1 → XP_036021049.1  M-phase phosphoprotein 9 isoform X1

    Conserved Domains (2) summary
    COG1196
    Location:556 → 759
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    PTZ00108
    Location:703 → 976
    PTZ00108; DNA topoisomerase 2-like protein; Provisional

  2. XM_030254544.1 → XP_030110404.1  M-phase phosphoprotein 9 isoform X5

    Conserved Domains (1) summary
    COG1196
    Location:198 → 383
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  3. XM_006530364.2 → XP_006530427.1  M-phase phosphoprotein 9 isoform X3

    See identical proteins and their annotated locations for XP_006530427.1

    Conserved Domains (2) summary
    COG1196
    Location:398 → 601
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15921
    Location:400 → 849
    CCDC158; Coiled-coil domain-containing protein 158

  4. XM_036165157.1 → XP_036021050.1  M-phase phosphoprotein 9 isoform X5

    Conserved Domains (1) summary
    COG1196
    Location:198 → 383
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  5. XM_011248205.1 → XP_011246507.1  M-phase phosphoprotein 9 isoform X3

    See identical proteins and their annotated locations for XP_011246507.1

    Conserved Domains (2) summary
    COG1196
    Location:398 → 601
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15921
    Location:400 → 849
    CCDC158; Coiled-coil domain-containing protein 158

  6. XM_011248206.1 → XP_011246508.1  M-phase phosphoprotein 9 isoform X5

    See identical proteins and their annotated locations for XP_011246508.1

    Conserved Domains (1) summary
    COG1196
    Location:198 → 383
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  7. XM_006530365.3 → XP_006530428.1  M-phase phosphoprotein 9 isoform X4

    Conserved Domains (1) summary
    COG1196
    Location:556 → 759
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

RNA

  1. XR_004942521.1 RNA Sequence

  2. XR_001784704.2 RNA Sequence

  3. XR_004942522.1 RNA Sequence

  4. XR_878687.2 RNA Sequence

  5. XR_003955654.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A6H5Y1.2 GenPept UniProtKB/Swiss-Prot:A6H5Y1

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