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Cfap251 cilia and flagella associated protein 251 [ Mus musculus (house mouse) ]

Gene ID: 269701, updated on 5-Mar-2024

Summary

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Official Symbol
Cfap251provided by MGI
Official Full Name
cilia and flagella associated protein 251provided by MGI
Primary source
MGI:MGI:1918495
See related
Ensembl:ENSMUSG00000029442 AllianceGenome:MGI:1918495
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Wdr66; 5031404N07; 4930415N18Rik; 4933428F06Rik
Summary
Predicted to be involved in flagellated sperm motility. Predicted to be located in cilium; cytoplasm; and cytoskeleton. Predicted to be active in sperm flagellum. Is expressed in brain; nasal cavity respiratory epithelium; neural retina; and respiratory system. Human ortholog(s) of this gene implicated in spermatogenic failure 33. Orthologous to human CFAP251 (cilia and flagella associated protein 251). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 15.4), lung adult (RPKM 2.3) and 5 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 F; 5 62.86 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (123390196..123465547)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (123251725..123327484)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene 4-hydroxyphenylpyruvic acid dioxygenase Neighboring gene STARR-positive B cell enhancer ABC_E9262 Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 9 Neighboring gene ribosomal protein L35A, pseudogene 6 Neighboring gene STARR-positive B cell enhancer ABC_E10350 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:123794689-123794872 Neighboring gene predicted gene 15860 Neighboring gene B cell CLL/lymphoma 7A Neighboring gene predicted gene, 23458

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Tissue expression patterns identify mouse cilia genes. McClintock TS, et al. Physiol Genomics, 2008 Jan 17. PMID 17971504
  2. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
  3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC33630

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in flagellated sperm motility ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cilium IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in motile cilium IEA
Inferred from Electronic Annotation
more info
  
is_active_in sperm flagellum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in sperm flagellum ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cilia- and flagella-associated protein 251
Names
WD repeat domain 66
WD repeat-containing protein 66

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001370840.1 → NP_001357769.1  cilia- and flagella-associated protein 251

    Status: VALIDATED

    Source sequence(s)
    AC113504, AC163337
    Consensus CDS
    CCDS89985.1
    UniProtKB/Swiss-Prot
    E9Q743, Q8BMR0, Q9D3X6
    Related
    ENSMUSP00000113309.2, ENSMUST00000121964.8
    Conserved Domains (4) summary
    PTZ00183
    Location:1136 → 1239
    PTZ00183; centrin; Provisional
    COG2319
    Location:423 → 870
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:658 → 688
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:756 → 1070
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    123390196..123465547
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030254542.2 → XP_030110402.1  cilia- and flagella-associated protein 251 isoform X1

    UniProtKB/Swiss-Prot
    E9Q743, Q8BMR0, Q9D3X6
    Conserved Domains (4) summary
    PTZ00183
    Location:1136 → 1239
    PTZ00183; centrin; Provisional
    COG2319
    Location:423 → 870
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:658 → 688
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:756 → 1070
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_177760.2: Suppressed sequence

    Description
    NM_177760.2: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E9Q743.1 GenPept UniProtKB/Swiss-Prot:E9Q743

Gene LinkOut

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