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Hectd4 HECT domain E3 ubiquitin protein ligase 4 [ Mus musculus (house mouse) ]

Gene ID: 269700, updated on 5-Mar-2024

Summary

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Official Symbol
Hectd4provided by MGI
Official Full Name
HECT domain E3 ubiquitin protein ligase 4provided by MGI
Primary source
MGI:MGI:3647820
See related
Ensembl:ENSMUSG00000042744 AllianceGenome:MGI:3647820
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm15800; EG545802; mKIAA0614; A130010L24
Summary
Predicted to be involved in glucose homeostasis and glucose metabolic process. Is expressed in several structures, including extraembryonic component; nervous system; neural retina; reproductive system; and tongue. Orthologous to human HECTD4 (HECT domain E3 ubiquitin protein ligase 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 19.5), whole brain E14.5 (RPKM 18.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 F; 5 61.72 cM
Exon count:
79
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (121357323..121506633)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (121219513..121368577)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase, non-receptor type 11 Neighboring gene STARR-positive B cell enhancer ABC_E4783 Neighboring gene STARR-positive B cell enhancer ABC_E6372 Neighboring gene STARR-seq mESC enhancer starr_14255 Neighboring gene STARR-positive B cell enhancer ABC_E4784 Neighboring gene predicted gene, 26205 Neighboring gene ribosomal protein L6 Neighboring gene STARR-positive B cell enhancer mm9_chr5:121780251-121780552 Neighboring gene predicted gene, 24671 Neighboring gene STARR-positive B cell enhancer ABC_E1688 Neighboring gene TRAF type zinc finger domain containing 1 Neighboring gene predicted gene, 42020 Neighboring gene N(alpha)-acetyltransferase 25, NatB auxiliary subunit Neighboring gene STARR-seq mESC enhancer starr_14257

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Upregulation of imprinted genes in mice: an insight into the intensity of gene expression and the evolution of genomic imprinting. Zaitoun I, et al. Epigenetics, 2010 Feb 16. PMID 20168089, Free PMC Article
  2. Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling. Angrand PO, et al. Mol Cell Proteomics, 2006 Dec. PMID 16959763
  3. Transcriptome analysis of mouse stem cells and early embryos. Sharov AA, et al. PLoS Biol, 2003 Dec. PMID 14691545, Free PMC Article
  4. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
  5. An Interaction Landscape of Ubiquitin Signaling. Zhang X, et al. Mol Cell, 2017 Mar 2. PMID 28190767

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in glucose homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glucose homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in glucose metabolic process ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
probable E3 ubiquitin-protein ligase HECTD4
NP_852086.3
XP_006530414.1
XP_006530415.1
XP_006530416.1
XP_006530417.1
XP_006530418.1
XP_006530419.1
XP_006530420.1
XP_006530421.3
XP_006530423.1
XP_011246506.1
XP_030110401.1
XP_036021046.1
XP_036021047.1
XP_036021048.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181421.5 → NP_852086.3  probable E3 ubiquitin-protein ligase HECTD4

    Status: VALIDATED

    Source sequence(s)
    AC110037, AC126938
    Consensus CDS
    CCDS57377.1
    UniProtKB/TrEMBL
    E9Q2E4
    Related
    ENSMUSP00000048345.7, ENSMUST00000042614.13
    Conserved Domains (3) summary
    smart00119
    Location:4060 → 4409
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd13735
    Location:2400 → 2555
    SPRY_HECT_like; SPRY domain in HECT E3
    cl00077
    Location:4020 → 4413
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    121357323..121506633
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530351.5 → XP_006530414.1  probable E3 ubiquitin-protein ligase HECTD4 isoform X1

    Conserved Domains (3) summary
    cd13735
    Location:2507 → 2662
    SPRY_HECT_like; SPRY domain in HECT E3
    pfam15450
    Location:149 → 233
    CCDC154; Coiled-coil domain-containing protein 154
    cl27008
    Location:4127 → 4520
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

  2. XM_006530353.5 → XP_006530416.1  probable E3 ubiquitin-protein ligase HECTD4 isoform X3

    Conserved Domains (3) summary
    cd13735
    Location:2507 → 2662
    SPRY_HECT_like; SPRY domain in HECT E3
    pfam15450
    Location:149 → 233
    CCDC154; Coiled-coil domain-containing protein 154
    cl27008
    Location:4126 → 4519
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

  3. XM_006530352.5 → XP_006530415.1  probable E3 ubiquitin-protein ligase HECTD4 isoform X2

    Conserved Domains (3) summary
    cd13735
    Location:2506 → 2661
    SPRY_HECT_like; SPRY domain in HECT E3
    pfam15450
    Location:149 → 233
    CCDC154; Coiled-coil domain-containing protein 154
    cl27008
    Location:4126 → 4519
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

  4. XM_006530355.5 → XP_006530418.1  probable E3 ubiquitin-protein ligase HECTD4 isoform X5

    Conserved Domains (3) summary
    cd13735
    Location:2502 → 2657
    SPRY_HECT_like; SPRY domain in HECT E3
    pfam15450
    Location:149 → 233
    CCDC154; Coiled-coil domain-containing protein 154
    cl27008
    Location:4122 → 4515
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

  5. XM_006530356.5 → XP_006530419.1  probable E3 ubiquitin-protein ligase HECTD4 isoform X6

    Conserved Domains (3) summary
    cd13735
    Location:2498 → 2653
    SPRY_HECT_like; SPRY domain in HECT E3
    pfam15450
    Location:149 → 233
    CCDC154; Coiled-coil domain-containing protein 154
    cl27008
    Location:4118 → 4511
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

  6. XM_006530360.5 → XP_006530423.1  probable E3 ubiquitin-protein ligase HECTD4 isoform X8

    Conserved Domains (3) summary
    cd13735
    Location:2493 → 2648
    SPRY_HECT_like; SPRY domain in HECT E3
    pfam15450
    Location:149 → 233
    CCDC154; Coiled-coil domain-containing protein 154
    cl27008
    Location:4113 → 4506
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

  7. XM_006530354.5 → XP_006530417.1  probable E3 ubiquitin-protein ligase HECTD4 isoform X4

    Conserved Domains (3) summary
    cd13735
    Location:2505 → 2660
    SPRY_HECT_like; SPRY domain in HECT E3
    pfam15450
    Location:149 → 233
    CCDC154; Coiled-coil domain-containing protein 154
    cl27008
    Location:4125 → 4518
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

  8. XM_006530357.5 → XP_006530420.1  probable E3 ubiquitin-protein ligase HECTD4 isoform X7

    Conserved Domains (3) summary
    cd13735
    Location:2496 → 2651
    SPRY_HECT_like; SPRY domain in HECT E3
    pfam15450
    Location:149 → 233
    CCDC154; Coiled-coil domain-containing protein 154
    cl27008
    Location:4116 → 4509
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

  9. XM_036165153.1 → XP_036021046.1  probable E3 ubiquitin-protein ligase HECTD4 isoform X9

    Conserved Domains (2) summary
    cd13735
    Location:2422 → 2577
    SPRY_HECT_like; SPRY domain in HECT E3
    cl27008
    Location:4042 → 4435
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

  10. XM_036165154.1 → XP_036021047.1  probable E3 ubiquitin-protein ligase HECTD4 isoform X10

    Conserved Domains (2) summary
    cd13735
    Location:2420 → 2575
    SPRY_HECT_like; SPRY domain in HECT E3
    cl27008
    Location:4040 → 4433
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

  11. XM_030254541.1 → XP_030110401.1  probable E3 ubiquitin-protein ligase HECTD4 isoform X14

    Conserved Domains (2) summary
    cd13735
    Location:1894 → 2049
    SPRY_HECT_like; SPRY domain in HECT E3
    cl27008
    Location:3514 → 3907
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

  12. XM_006530358.5 → XP_006530421.3  probable E3 ubiquitin-protein ligase HECTD4 isoform X11

    Conserved Domains (2) summary
    cd13735
    Location:2389 → 2544
    SPRY_HECT_like; SPRY domain in HECT E3
    cl27008
    Location:4009 → 4402
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

  13. XM_036165155.1 → XP_036021048.1  probable E3 ubiquitin-protein ligase HECTD4 isoform X13

    Conserved Domains (2) summary
    cd13735
    Location:2124 → 2279
    SPRY_HECT_like; SPRY domain in HECT E3
    cl27008
    Location:3744 → 4137
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

  14. XM_011248204.4 → XP_011246506.1  probable E3 ubiquitin-protein ligase HECTD4 isoform X12

    Conserved Domains (2) summary
    cd13735
    Location:2377 → 2532
    SPRY_HECT_like; SPRY domain in HECT E3
    cl27008
    Location:3997 → 4390
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
Nucleotide Protein Strain
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