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Ccdc60 coiled-coil domain containing 60 [ Mus musculus (house mouse) ]

Gene ID: 269693, updated on 5-Mar-2024

Summary

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Official Symbol
Ccdc60provided by MGI
Official Full Name
coiled-coil domain containing 60provided by MGI
Primary source
MGI:MGI:2141043
See related
Ensembl:ENSMUSG00000043913 AllianceGenome:MGI:2141043
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C130098D09
Summary
Is expressed in central nervous system; craniocervical region bone; dorsal root ganglion; and rib. Orthologous to human CCDC60 (coiled-coil domain containing 60). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 123.1) See more
Orthologs
human all
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Genomic context

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Location:
5 F; 5 56.12 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (116263640..116427059, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (116125581..116289000, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8073 Neighboring gene predicted gene 13842 Neighboring gene transmembrane protein 233 Neighboring gene RIKEN cDNA C330018A13 gene Neighboring gene STARR-seq mESC enhancer starr_14145 Neighboring gene predicted gene, 36552 Neighboring gene predicted gene, 36502 Neighboring gene predicted gene, 52827 Neighboring gene RIKEN cDNA B230112J18 gene Neighboring gene RIKEN cDNA 4933424N20 gene Neighboring gene STARR-seq mESC enhancer starr_14150

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  2. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
coiled-coil domain-containing protein 60

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360004.1 → NP_001346933.1  coiled-coil domain-containing protein 60 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction in the 5' end compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.
    Source sequence(s)
    AC115795, AC119977, AC158756
    UniProtKB/TrEMBL
    B7ZWG5
    Conserved Domains (1) summary
    pfam15769
    Location:59 → 533
    DUF4698; Domain of unknown function (DUF4698)

  2. NM_001360005.1 → NP_001346934.1  coiled-coil domain-containing protein 60 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC158756, BC075662
    Consensus CDS
    CCDS89981.1
    UniProtKB/TrEMBL
    A0A0R4J120
    Related
    ENSMUSP00000083671.4, ENSMUST00000086483.4
    Conserved Domains (1) summary
    pfam15769
    Location:60 → 187
    DUF4698; Domain of unknown function (DUF4698)

  3. NM_177759.3 → NP_808427.1  coiled-coil domain-containing protein 60 isoform 1

    See identical proteins and their annotated locations for NP_808427.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK082047
    Consensus CDS
    CCDS19599.1
    UniProtKB/Swiss-Prot
    B2RX39, Q6DIA4, Q6PAQ3, Q8C4J0
    UniProtKB/TrEMBL
    B7ZWG5
    Related
    ENSMUSP00000049912.7, ENSMUST00000050178.13
    Conserved Domains (1) summary
    pfam15769
    Location:60 → 534
    DUF4698; Domain of unknown function (DUF4698)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    116263640..116427059 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017320898.2 → XP_017176387.1  coiled-coil domain-containing protein 60 isoform X2

    UniProtKB/TrEMBL
    B7ZWG5
    Conserved Domains (1) summary
    pfam15769
    Location:59 → 550
    DUF4698; Domain of unknown function (DUF4698)

  2. XM_030254535.1 → XP_030110395.1  coiled-coil domain-containing protein 60 isoform X4

    UniProtKB/TrEMBL
    B7ZWG5
    Conserved Domains (1) summary
    pfam15769
    Location:60 → 533
    DUF4698; Domain of unknown function (DUF4698)

  3. XM_017320899.2 → XP_017176388.1  coiled-coil domain-containing protein 60 isoform X3

    UniProtKB/TrEMBL
    B7ZWG5
    Conserved Domains (1) summary
    pfam15769
    Location:60 → 550
    DUF4698; Domain of unknown function (DUF4698)

  4. XM_006530340.4 → XP_006530403.1  coiled-coil domain-containing protein 60 isoform X1

    UniProtKB/TrEMBL
    B7ZWG5
    Conserved Domains (1) summary
    pfam15769
    Location:60 → 551
    DUF4698; Domain of unknown function (DUF4698)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C4J0.1 GenPept UniProtKB/Swiss-Prot:Q8C4J0

Gene LinkOut

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