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Islr immunoglobulin superfamily containing leucine-rich repeat [ Mus musculus (house mouse) ]

Gene ID: 26968, updated on 5-Mar-2024

Summary

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Official Symbol
Islrprovided by MGI
Official Full Name
immunoglobulin superfamily containing leucine-rich repeatprovided by MGI
Primary source
MGI:MGI:1349645
See related
Ensembl:ENSMUSG00000037206 AllianceGenome:MGI:1349645
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Meflin
Summary
Located in extracellular space. Is expressed in several structures, including embryo mesenchyme; genitourinary system; meninges; musculature; and retina layer. Orthologous to human ISLR (immunoglobulin superfamily containing leucine rich repeat). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in limb E14.5 (RPKM 168.1), mammary gland adult (RPKM 124.5) and 20 other tissues See more
Orthologs
human all
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Genomic context

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See Islr in Genome Data Viewer
Location:
9 B; 9 31.63 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (58063547..58066563, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (58156246..58159236, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 33 Neighboring gene predicted gene 16130 Neighboring gene stimulated by retinoic acid gene 6 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:57960192-57960379 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:57981876-57982059 Neighboring gene predicted gene, 39344 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E10552 Neighboring gene immunoglobulin superfamily containing leucine-rich repeat 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Pharmacologic conversion of cancer-associated fibroblasts from a protumor phenotype to an antitumor phenotype improves the sensitivity of pancreatic cancer to chemotherapeutics. Iida T, et al. Oncogene, 2022 May. PMID 35414659
  2. Immunoglobulin Superfamily Containing Leucine-Rich Repeat (Islr) Participates in IL-6-Mediated Crosstalk between Muscle and Brown Adipose Tissue to Regulate Energy Homeostasis. Liu C, et al. Int J Mol Sci, 2022 Sep 2. PMID 36077405, Free PMC Article
  3. A novel renal perivascular mesenchymal cell subset gives rise to fibroblasts distinct from classic myofibroblasts. Minatoguchi S, et al. Sci Rep, 2022 Mar 30. PMID 35354870, Free PMC Article
  4. Meflin defines mesenchymal stem cells and/or their early progenitors with multilineage differentiation capacity. Hara A, et al. Genes Cells, 2021 Jul. PMID 33960573, Free PMC Article
  5. Cancer-associated fibroblasts that restrain cancer progression: Hypotheses and perspectives. Miyai Y, et al. Cancer Sci, 2020 Apr. PMID 32060987, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Meflin is a marker of pancreatic stellate cells involved in fibrosis and epithelial regeneration in the pancreas.
    Title: Meflin is a marker of pancreatic stellate cells involved in fibrosis and epithelial regeneration in the pancreas.
  2. Islr regulates insulin sensitivity by interacting with Psma4 to control insulin receptor alpha levels in obese mice.
    Title: Islr regulates insulin sensitivity by interacting with Psma4 to control insulin receptor alpha levels in obese mice.
  3. Meflin defines mesenchymal stem cells and/or their early progenitors with multilineage differentiation capacity.
    Title: Meflin defines mesenchymal stem cells and/or their early progenitors with multilineage differentiation capacity.
  4. Meflin deficiency led to significant tumor progression with poorly differentiated histology in a PDAC mouse model. Meflin deficiency or low expression resulted in straightened stromal collagen fibers, which represent a signature for aggressive tumors, in mousePDAC tissues.
    Title: Meflin-Positive Cancer-Associated Fibroblasts Inhibit Pancreatic Carcinogenesis.
  5. Meflin interacts with bone morphogenetic protein 7. Meflin knockout mice developed marked cardiac interstitial fibrosis with defective compensation mechanisms.
    Title: Roles of the Mesenchymal Stromal/Stem Cell Marker Meflin in Cardiac Tissue Repair and the Development of Diastolic Dysfunction.
  6. Immunoglobulin superfamily containing leucine-rich repeat protein (Islr) interacts with Dishevelled-2 (Dvl2) to activate canonical Wnt signaling.
    Title: Islr regulates canonical Wnt signaling-mediated skeletal muscle regeneration by stabilizing Dishevelled-2 and preventing autophagy.
  7. Those results are consistent with a decrease in the number of clonogenic colony-forming unit-fibroblasts within the BM of Meflin-deficient mice. These preliminary data suggest that Meflin is a potential marker for cultured MSCs and their source cells in vivo.
    Title: Identification of Meflin as a Potential Marker for Mesenchymal Stromal Cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space HDA PubMed 

General protein information

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Preferred Names
immunoglobulin superfamily containing leucine-rich repeat protein
Names
mesenchymal stromal cell- and fibroblast-expressing Linx paralogue

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001195431.1 → NP_001182360.1  immunoglobulin superfamily containing leucine-rich repeat protein precursor

    See identical proteins and their annotated locations for NP_001182360.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a different segment for its 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC158996, AC160976, AI838480
    Consensus CDS
    CCDS23237.1
    UniProtKB/Swiss-Prot
    Q6GU68
    UniProtKB/TrEMBL
    A0A146E664
    Related
    ENSMUSP00000126963.3, ENSMUST00000168864.4
    Conserved Domains (6) summary
    cd00096
    Location:255 → 341
    Ig; Immunoglobulin domain
    smart00082
    Location:180 → 228
    LRRCT; Leucine rich repeat C-terminal domain
    cd00116
    Location:50 → 181
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam07679
    Location:239 → 343
    I-set; Immunoglobulin I-set domain
    sd00033
    Location:32 → 51
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:98 → 158
    LRR_8; Leucine rich repeat

  2. NM_012043.4 → NP_036173.1  immunoglobulin superfamily containing leucine-rich repeat protein precursor

    See identical proteins and their annotated locations for NP_036173.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC158996, AC160976, AI838480
    Consensus CDS
    CCDS23237.1
    UniProtKB/Swiss-Prot
    Q6GU68
    UniProtKB/TrEMBL
    A0A146E664
    Related
    ENSMUSP00000045142.8, ENSMUST00000041477.15
    Conserved Domains (6) summary
    cd00096
    Location:255 → 341
    Ig; Immunoglobulin domain
    smart00082
    Location:180 → 228
    LRRCT; Leucine rich repeat C-terminal domain
    cd00116
    Location:50 → 181
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam07679
    Location:239 → 343
    I-set; Immunoglobulin I-set domain
    sd00033
    Location:32 → 51
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:98 → 158
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    58063547..58066563 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006511204.4 → XP_006511267.1  immunoglobulin superfamily containing leucine-rich repeat protein isoform X1

    See identical proteins and their annotated locations for XP_006511267.1

    Conserved Domains (4) summary
    TIGR00864
    Location:161 → 235
    PCC; polycystin cation channel protein
    sd00033
    Location:40 → 59
    LRR_RI; leucine-rich repeat [structural motif]
    cd00096
    Location:263 → 349
    Ig; Immunoglobulin domain
    pfam13855
    Location:107 → 166
    LRR_8; Leucine rich repeat

  2. XM_011242750.4 → XP_011241052.1  immunoglobulin superfamily containing leucine-rich repeat protein isoform X1

    See identical proteins and their annotated locations for XP_011241052.1

    Conserved Domains (4) summary
    TIGR00864
    Location:161 → 235
    PCC; polycystin cation channel protein
    sd00033
    Location:40 → 59
    LRR_RI; leucine-rich repeat [structural motif]
    cd00096
    Location:263 → 349
    Ig; Immunoglobulin domain
    pfam13855
    Location:107 → 166
    LRR_8; Leucine rich repeat
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6GU68.1 GenPept UniProtKB/Swiss-Prot:Q6GU68

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