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Cul1 cullin 1 [ Mus musculus (house mouse) ]

Gene ID: 26965, updated on 21-Apr-2024

Summary

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Official Symbol
Cul1provided by MGI
Official Full Name
cullin 1provided by MGI
Primary source
MGI:MGI:1349658
See related
Ensembl:ENSMUSG00000029686 AllianceGenome:MGI:1349658
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cul-1
Summary
Predicted to enable ubiquitin protein ligase binding activity and ubiquitin-protein transferase activity. Predicted to contribute to ubiquitin protein ligase activity. Involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Acts upstream of or within several processes, including animal organ morphogenesis; apoptotic process; and protein ubiquitination. Part of SCF ubiquitin ligase complex. Is expressed in several structures, including adrenal gland; genitourinary system; immune system; neural retina; and telencephalon. Orthologous to human CUL1 (cullin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 25.9), bladder adult (RPKM 24.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 B2.3; 6 22.9 cM
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (47430516..47503078)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (47453732..47526144)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene contactin associated protein-like 2 Neighboring gene STARR-seq mESC enhancer starr_15777 Neighboring gene predicted gene, 53327 Neighboring gene STARR-seq mESC enhancer starr_15778 Neighboring gene RIKEN cDNA F830010H11 gene Neighboring gene STARR-positive B cell enhancer mm9_chr6:47544952-47545253 Neighboring gene STARR-seq mESC enhancer starr_15780 Neighboring gene STARR-seq mESC enhancer starr_15781 Neighboring gene STARR-positive B cell enhancer ABC_E4823 Neighboring gene TAR (HIV) RNA binding protein 2 pseudogene Neighboring gene predicted gene, 40371 Neighboring gene enhancer of zeste 2 polycomb repressive complex 2 subunit

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. New insights into the roles of CUL1 in mouse placenta development. Zeng L, et al. Biochem Biophys Res Commun, 2021 Jun 25. PMID 33933992
  2. Knockout Mouse Models Provide Insight into the Biological Functions of CRL1 Components. Nakagawa T, et al. Adv Exp Med Biol, 2020. PMID 31898227
  3. Antiinflammatory adaptation to hypoxia through adenosine-mediated cullin-1 deneddylation. Khoury J, et al. J Clin Invest, 2007 Mar. PMID 17318263, Free PMC Article
  4. Deletion of the Cul1 gene in mice causes arrest in early embryogenesis and accumulation of cyclin E. Wang Y, et al. Curr Biol, 1999 Oct 21. PMID 10531039
  5. Interaction between dual specificity phosphatase-1 and cullin-1 attenuates alcohol-related liver disease by restoring p62-mediated mitophagy. Li R, et al. Int J Biol Sci, 2023. PMID 37063418, Free PMC Article

See all (80) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. New insights into the roles of CUL1 in mouse placenta development.
    Title: New insights into the roles of CUL1 in mouse placenta development.
  2. REVIEW: comprehensive overview of mouse models and discussion of the role of each CRL1 component in mouse physiology and pathology
    Title: Knockout Mouse Models Provide Insight into the Biological Functions of CRL1 Components.
  3. Cul-1 deneddylation led to Deptor accumulation and subsequent mTOR inactivation, which had an inhibitory effect on dendritic cells in mouse model of inflammatory bowel disease.
    Title: Inhibition of neddylation regulates dendritic cell functions via Deptor accumulation driven mTOR inactivation.
  4. Lysine 29-linkage of ASK1 by Skp1-Cullin 1-Fbxo21 ubiquitin ligase complex is required for antiviral innate response.
    Title: Lys29-linkage of ASK1 by Skp1-Cullin 1-Fbxo21 ubiquitin ligase complex is required for antiviral innate response.
  5. Substrate binding promotes formation of the Skp1-Cul1-Fbxl3 (SCF(Fbxl3)) protein complex.
    Title: Substrate binding promotes formation of the Skp1-Cul1-Fbxl3 (SCF(Fbxl3)) protein complex.
  6. Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction.
    Title: Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction.
  7. SCCRO recruits Ubc12 approximately NEDD8 to the CAND1-Cul1-ROC1 complex but that this is not sufficient to dissociate or overcome the inhibitory effects of CAND1 on cullin neddylation
    Title: SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation.
  8. Analysis of cell cycle regulatory genes reveals defective induction of the c-Myc:CUL1 ubiquitin ligase pathway in B cells from CD22-deficient mice in the context of a C57BL/6 genetic background, following IgM ligation compared with wild-type B cells.
    Title: Severely impaired B lymphocyte proliferation, survival, and induction of the c-Myc:Cullin 1 ubiquitin ligase pathway resulting from CD22 deficiency on the C57BL/6 genetic background.
  9. Skp2 and Cul1 expression is repressed by GATA2, thereby inhibiting ubiquitin/proteasome-dependent degradation of p21(WAF1) and p27(Kip1), inducing their accumulation, and suppressing hematopoietic stem cell growth
    Title: GATA-2/estrogen receptor chimera regulates cytokine-dependent growth of hematopoietic cells through accumulation of p21(WAF1) and p27(Kip1) proteins.
  10. Cul7 forms a heterodimeric complex with Cul1 in a manner dependent on Fbxw8.
    Title: Fbxw8 is essential for Cul1-Cul7 complex formation and for placental development.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-macromolecule adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin ligase complex scaffold activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to ubiquitin protein ligase activity IC
Inferred by Curator
more info
 PubMed 
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within animal organ morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein K48-linked ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein K48-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein monoubiquitination IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process IC
Inferred by Curator
more info
 PubMed 
Component Evidence Code Pubs
part_of Parkin-FBXW7-Cul1 ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SCF ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of SCF ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
part_of cullin-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cullin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355550.2 → NP_001342479.1  cullin-1

    Status: VALIDATED

    Source sequence(s)
    AC154014, AC154015
    Consensus CDS
    CCDS20095.1
    UniProtKB/Swiss-Prot
    Q9WTX6, Q9WUI7
    UniProtKB/TrEMBL
    Q3UIA5
    Conserved Domains (2) summary
    pfam00888
    Location:21 → 660
    Cullin; Cullin family
    pfam10557
    Location:706 → 767
    Cullin_Nedd8; Cullin protein neddylation domain

  2. NM_001355551.2 → NP_001342480.1  cullin-1

    Status: VALIDATED

    Source sequence(s)
    AC154014, AC154015
    Consensus CDS
    CCDS20095.1
    UniProtKB/Swiss-Prot
    Q9WTX6, Q9WUI7
    UniProtKB/TrEMBL
    Q3UIA5
    Related
    ENSMUSP00000122702.2, ENSMUST00000146200.8
    Conserved Domains (2) summary
    pfam00888
    Location:21 → 660
    Cullin; Cullin family
    pfam10557
    Location:706 → 767
    Cullin_Nedd8; Cullin protein neddylation domain

  3. NM_001410599.1 → NP_001397528.1  cullin-1

    Status: VALIDATED

    Source sequence(s)
    AC154014, AC154015
    UniProtKB/Swiss-Prot
    Q9WTX6, Q9WUI7

  4. NM_001410600.1 → NP_001397529.1  cullin-1

    Status: VALIDATED

    Source sequence(s)
    AC154014, AC154015
    UniProtKB/Swiss-Prot
    Q9WTX6, Q9WUI7

  5. NM_001410601.1 → NP_001397530.1  cullin-1

    Status: VALIDATED

    Source sequence(s)
    AC154014, AC154015
    UniProtKB/Swiss-Prot
    Q9WTX6, Q9WUI7

  6. NM_001410602.1 → NP_001397531.1  cullin-1

    Status: VALIDATED

    Source sequence(s)
    AC154014, AC154015
    UniProtKB/Swiss-Prot
    Q9WTX6, Q9WUI7

  7. NM_012042.5 → NP_036172.1  cullin-1

    See identical proteins and their annotated locations for NP_036172.1

    Status: VALIDATED

    Source sequence(s)
    AC154014, AC154015
    Consensus CDS
    CCDS20095.1
    UniProtKB/Swiss-Prot
    Q9WTX6, Q9WUI7
    UniProtKB/TrEMBL
    Q3UIA5
    Related
    ENSMUSP00000031697.9, ENSMUST00000031697.9
    Conserved Domains (2) summary
    pfam00888
    Location:21 → 660
    Cullin; Cullin family
    pfam10557
    Location:706 → 767
    Cullin_Nedd8; Cullin protein neddylation domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    47430516..47503078
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WTX6.1 GenPept UniProtKB/Swiss-Prot:Q9WTX6

Gene LinkOut

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