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Fbxl4 F-box and leucine-rich repeat protein 4 [ Mus musculus (house mouse) ]

Gene ID: 269514, updated on 3-Apr-2024

Summary

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Official Symbol
Fbxl4provided by MGI
Official Full Name
F-box and leucine-rich repeat protein 4provided by MGI
Primary source
MGI:MGI:2140367
See related
Ensembl:ENSMUSG00000040410 AllianceGenome:MGI:2140367
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FBL4; FBL5
Summary
Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be located in mitochondrial intermembrane space and nuclear speck. Predicted to be part of SCF ubiquitin ligase complex. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome 13. Orthologous to human FBXL4 (F-box and leucine rich repeat protein 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in subcutaneous fat pad adult (RPKM 7.6), genital fat pad adult (RPKM 6.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 A3; 4 9.69 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (22357526..22434091)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (22357526..22434091)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_09737 Neighboring gene predicted gene, 42260 Neighboring gene STARR-seq mESC enhancer starr_09738 Neighboring gene STARR-seq mESC enhancer starr_09742 Neighboring gene STARR-seq mESC enhancer starr_09743 Neighboring gene STARR-seq mESC enhancer starr_09745 Neighboring gene STARR-seq mESC enhancer starr_09746 Neighboring gene STARR-seq mESC enhancer starr_09747 Neighboring gene STARR-seq mESC enhancer starr_09748 Neighboring gene PEST proteolytic signal-containing nuclear protein pseudogene Neighboring gene STARR-seq mESC enhancer starr_09749 Neighboring gene predicted gene, 24607 Neighboring gene STARR-seq mESC enhancer starr_09750 Neighboring gene STARR-seq mESC enhancer starr_09751 Neighboring gene predicted gene, 30731 Neighboring gene POU domain, class 3, transcription factor 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. FBXL4 deficiency increases mitochondrial removal by autophagy. Alsina D, et al. EMBO Mol Med, 2020 Jul 7. PMID 32525278, Free PMC Article
  2. Systematic analysis and nomenclature of mammalian F-box proteins. Jin J, et al. Genes Dev, 2004 Nov 1. PMID 15520277, Free PMC Article
  3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  4. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FBXL4 protects against HFpEF through Drp1-Mediated regulation of mitochondrial dynamics and the downstream SERCA2a.
    Title: FBXL4 protects against HFpEF through Drp1-Mediated regulation of mitochondrial dynamics and the downstream SERCA2a.
  2. FBXL4 deficiency increases mitochondrial removal by autophagy.
    Title: FBXL4 deficiency increases mitochondrial removal by autophagy.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • 4732456I21

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within autophagy of mitochondrion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within autophagy of mitochondrion ISO
Inferred from Sequence Orthology
more info
 PubMed 
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial intermembrane space ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
F-box/LRR-repeat protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001425044.1 → NP_001411973.1  F-box/LRR-repeat protein 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL683854, AL772230
    UniProtKB/Swiss-Prot
    Q8BH70

  2. NM_001425045.1 → NP_001411974.1  F-box/LRR-repeat protein 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL683854, AL772230
    UniProtKB/Swiss-Prot
    Q8BH70

  3. NM_001425046.1 → NP_001411975.1  F-box/LRR-repeat protein 4 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL683854, AL772230

  4. NM_172988.5 → NP_766576.1  F-box/LRR-repeat protein 4 isoform 1

    See identical proteins and their annotated locations for NP_766576.1

    Status: VALIDATED

    Source sequence(s)
    AL683854, AL772230
    Consensus CDS
    CCDS18004.1
    UniProtKB/Swiss-Prot
    Q8BH70
    UniProtKB/TrEMBL
    Q8CIC4
    Related
    ENSMUSP00000042219.4, ENSMUST00000039234.10
    Conserved Domains (3) summary
    cd09293
    Location:394 → 601
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:347 → 376
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:280 → 318
    F-box-like

RNA

  1. NR_104378.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL683854, AL772230
    Related
    ENSMUST00000185029.8

  2. NR_104379.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL683854, AL772230

  3. NR_104380.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL683854, AL772230
    Related
    ENSMUST00000184455.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    22357526..22434091
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017320233.3 → XP_017175722.1  F-box/LRR-repeat protein 4 isoform X2

    UniProtKB/TrEMBL
    Q8CIC4, V9GXH8
    Related
    ENSMUSP00000139158.2, ENSMUST00000184582.2
    Conserved Domains (3) summary
    cd09293
    Location:394 → 558
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:347 → 376
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:280 → 318
    F-box-like

RNA

  1. XR_004941910.1 RNA Sequence

  2. XR_881066.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BH70.1 GenPept UniProtKB/Swiss-Prot:Q8BH70

Gene LinkOut

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