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Zw10 zw10 kinetochore protein [ Mus musculus (house mouse) ]

Gene ID: 26951, updated on 5-Mar-2024

Summary

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Official Symbol
Zw10provided by MGI
Official Full Name
zw10 kinetochore proteinprovided by MGI
Primary source
MGI:MGI:1349478
See related
Ensembl:ENSMUSG00000032264 AllianceGenome:MGI:1349478
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MmZw10; 6330566F14Rik
Summary
Predicted to be involved in several processes, including establishment of mitotic spindle orientation; mitotic metaphase plate congression; and regulation of mitotic cell cycle phase transition. Predicted to act upstream of or within cell division; protein transport; and vesicle-mediated transport. Predicted to be located in several cellular components, including kinetochore; lipid droplet; and spindle. Predicted to be part of Dsl1/NZR complex and RZZ complex. Orthologous to human ZW10 (zw10 kinetochore protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 15.1), limb E14.5 (RPKM 13.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 A5.3; 9 26.58 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (48966880..48990075)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (49055576..49078775)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 28 Neighboring gene predicted gene, 53522 Neighboring gene STARR-seq mESC enhancer starr_24085 Neighboring gene claudin 25 Neighboring gene STARR-seq mESC enhancer starr_24086 Neighboring gene transmembrane protease, serine 5 (spinesin) Neighboring gene STARR-seq mESC enhancer starr_24087 Neighboring gene STARR-seq mESC enhancer starr_24088 Neighboring gene STARR-seq mESC enhancer starr_24089 Neighboring gene predicted gene 4894

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Zw10 is a spindle assembly checkpoint protein that regulates meiotic maturation in mouse oocytes. Park Y, et al. Histochem Cell Biol, 2019 Sep. PMID 31250100
  2. Conservation of the centromere/kinetochore protein ZW10. Starr DA, et al. J Cell Biol, 1997 Sep 22. PMID 9298984, Free PMC Article
  3. Systematic analysis of human protein complexes identifies chromosome segregation proteins. Hutchins JR, et al. Science, 2010 Apr 30. PMID 20360068, Free PMC Article
  4. The central role of EED in the orchestration of polycomb group complexes. Cao Q, et al. Nat Commun, 2014. PMID 24457600, Free PMC Article
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in Golgi organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
  
involved_in establishment of mitotic spindle orientation ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic metaphase chromosome alignment ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic sister chromatid segregation ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic spindle assembly checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic spindle assembly checkpoint signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to kinetochore ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of exit from mitosis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Dsl1/NZR complex ISO
Inferred from Sequence Orthology
more info
  
part_of RZZ complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RZZ complex ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
  
located_in kinetochore microtubule ISO
Inferred from Sequence Orthology
more info
  
located_in lipid droplet ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in spindle pole ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
centromere/kinetochore protein zw10 homolog
Names
ZW10 homolog, centromere/kinetochore protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012039.2 → NP_036169.1  centromere/kinetochore protein zw10 homolog

    See identical proteins and their annotated locations for NP_036169.1

    Status: VALIDATED

    Source sequence(s)
    AK168479, BC067405, CJ172982
    Consensus CDS
    CCDS23161.1
    UniProtKB/Swiss-Prot
    O54692, Q3TIA5, Q3ULW1, Q921H3
    Related
    ENSMUSP00000034803.9, ENSMUST00000034803.10
    Conserved Domains (2) summary
    pfam06248
    Location:9 → 621
    Zw10; Centromere/kinetochore Zw10
    cl21453
    Location:598 → 768
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    48966880..48990075
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006510371.4 → XP_006510434.1  centromere/kinetochore protein zw10 homolog isoform X1

    Conserved Domains (2) summary
    pfam06248
    Location:5 → 347
    Zw10; Centromere/kinetochore Zw10
    cl21453
    Location:381 → 551
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O54692.3 GenPept UniProtKB/Swiss-Prot:O54692

Gene LinkOut

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