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Lrig2 leucine-rich repeats and immunoglobulin-like domains 2 [ Mus musculus (house mouse) ]

Gene ID: 269473, updated on 5-Mar-2024

Summary

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Official Symbol
Lrig2provided by MGI
Official Full Name
leucine-rich repeats and immunoglobulin-like domains 2provided by MGI
Primary source
MGI:MGI:2443718
See related
Ensembl:ENSMUSG00000032913 AllianceGenome:MGI:2443718
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LIG-2; 4632419I10Rik
Summary
Enables signaling receptor binding activity. Acts upstream of or within several processes, including negative regulation of axon regeneration; negative regulation of membrane protein ectodomain proteolysis; and positive regulation of protein localization to cell surface. Located in several cellular components, including growth cone; intracellular vesicle; and neuronal cell body. Is expressed in several structures, including branchial arch; central nervous system; eye; inner ear; and nasal pit. Human ortholog(s) of this gene implicated in urofacial syndrome. Orthologous to human LRIG2 (leucine rich repeats and immunoglobulin like domains 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 7.1), whole brain E14.5 (RPKM 6.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 F2.2; 3 45.62 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (104361296..104419251, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (104453980..104511918, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene 5546 Neighboring gene STARR-seq mESC enhancer starr_08609 Neighboring gene STARR-seq mESC enhancer starr_08610 Neighboring gene predicted gene, 38412 Neighboring gene STARR-seq mESC enhancer starr_08611 Neighboring gene phosducin-like 3 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E4569 Neighboring gene STARR-seq mESC enhancer starr_08613 Neighboring gene STARR-seq mESC enhancer starr_08614 Neighboring gene STARR-seq mESC enhancer starr_08615 Neighboring gene STARR-seq mESC enhancer starr_08617 Neighboring gene STARR-positive B cell enhancer ABC_E4570 Neighboring gene VISTA enhancer mm1537 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:104369426-104369609 Neighboring gene predicted gene, 34490 Neighboring gene predicted gene, 54213

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. LRIG2 regulates cell proliferation, migration and apoptosis of osteosarcoma. Li ZQ, et al. BMC Cancer, 2022 Oct 1. PMID 36183058, Free PMC Article
  2. Lrig2-deficient mice are protected against PDGFB-induced glioma. Rondahl V, et al. PLoS One, 2013. PMID 24023893, Free PMC Article
  3. Lrig2 and Hpse2, mutated in urofacial syndrome, pattern nerves in the urinary bladder. Roberts NA, et al. Kidney Int, 2019 May. PMID 30885509, Free PMC Article
  4. Urinary tract effects of HPSE2 mutations. Stuart HM, et al. J Am Soc Nephrol, 2015 Apr. PMID 25145936, Free PMC Article
  5. In vivo analysis of Lrig genes reveals redundant and independent functions in the inner ear. Del Rio T, et al. PLoS Genet, 2013. PMID 24086156, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LRIG2 regulates cell proliferation, migration and apoptosis of osteosarcoma.
    Title: LRIG2 regulates cell proliferation, migration and apoptosis of osteosarcoma.
  2. Mice with homozygous mutations in either Lrig2 or Hpse2 had increased nerve density within the urinary bladder body and decreased nerve density around the urinary outflow tract. Observations provide evidence that a peripheral neuropathy is central to the pathobiology of functional bladder outlet obstruction in urofacial syndrome and emphasize the importance of LRIG2 and Hpse2 for nerve patterning in the urinary tract.
    Title: Lrig2 and Hpse2, mutated in urofacial syndrome, pattern nerves in the urinary bladder.
  3. Lrig2 has a role in negative regulation of ectodomain shedding of axon guidance receptors by ADAM17 protease
    Title: Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases.
  4. phenotype of Lrig2E12-/- mice showed that Lrig2 was a promoter of PDGFB-induced glioma
    Title: Lrig2-deficient mice are protected against PDGFB-induced glioma.
  5. At later stages, Lrig1 expression is sustained in non-sensory tissues, whereas Lrig2 levels are enhanced in neurons and sensory epithelia
    Title: In vivo analysis of Lrig genes reveals redundant and independent functions in the inner ear.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within innervation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of membrane protein ectodomain proteolysis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of axon regeneration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of membrane protein ectodomain proteolysis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of neuron projection development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within positive regulation of protein localization to cell surface IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of protein localization to cell surface IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of axon regeneration IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of neuron migration IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of platelet-derived growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in growth cone IDA
Inferred from Direct Assay
more info
 PubMed 
located_in intracellular vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
leucine-rich repeats and immunoglobulin-like domains protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025067.2 → NP_001020238.1  leucine-rich repeats and immunoglobulin-like domains protein 2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001020238.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC094228, BY205369, CN532345
    Consensus CDS
    CCDS17701.1
    UniProtKB/Swiss-Prot
    Q52KR2, Q69ZY8
    Related
    ENSMUSP00000035999.7, ENSMUST00000046316.11
    Conserved Domains (10) summary
    cd05763
    Location:618 → 692
    Ig_1; Subgroup of the immunoglobulin (Ig) superfamily
    smart00082
    Location:444 → 492
    LRRCT; Leucine rich repeat C-terminal domain
    smart00410
    Location:503 → 597
    IG_like; Immunoglobulin like
    cd00116
    Location:16 → 204
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam07679
    Location:601 → 691
    I-set; Immunoglobulin I-set domain
    sd00031
    Location:53 → 75
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:145 → 167
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:385 → 426
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:311 → 370
    LRR_8; Leucine rich repeat
    cl11960
    Location:713 → 782
    Ig; Immunoglobulin domain

  2. NM_001310698.1 → NP_001297627.1  leucine-rich repeats and immunoglobulin-like domains protein 2 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001297627.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in its 3' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AK036116, BC094228, BY205369, CK636907, CN532345
    Consensus CDS
    CCDS79993.1
    UniProtKB/TrEMBL
    B2RRI5
    Related
    ENSMUSP00000142540.2, ENSMUST00000198332.2
    Conserved Domains (10) summary
    cd05763
    Location:618 → 692
    Ig_1; Subgroup of the immunoglobulin (Ig) superfamily
    smart00082
    Location:444 → 492
    LRRCT; Leucine rich repeat C-terminal domain
    smart00410
    Location:503 → 597
    IG_like; Immunoglobulin like
    cd00116
    Location:16 → 204
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam07679
    Location:601 → 691
    I-set; Immunoglobulin I-set domain
    sd00031
    Location:53 → 75
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:145 → 167
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:385 → 426
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:311 → 370
    LRR_8; Leucine rich repeat
    cl11960
    Location:713 → 782
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    104361296..104419251 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017319602.3 → XP_017175091.1  leucine-rich repeats and immunoglobulin-like domains protein 2 isoform X3

    Related
    ENSMUSP00000142373.2, ENSMUST00000199070.5
    Conserved Domains (4) summary
    cd05763
    Location:200 → 274
    Ig_1; Subgroup of the immunoglobulin (Ig) superfamily
    smart00082
    Location:26 → 74
    LRRCT; Leucine rich repeat C-terminal domain
    pfam07679
    Location:277 → 364
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:83 → 179
    Ig; Immunoglobulin domain

  2. XM_036163127.1 → XP_036019020.1  leucine-rich repeats and immunoglobulin-like domains protein 2 isoform X1

    Conserved Domains (10) summary
    TIGR00864
    Location:367 → 444
    PCC; polycystin cation channel protein
    sd00031
    Location:53 → 75
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:145 → 167
    LRR_RI; leucine-rich repeat [structural motif]
    pfam07679
    Location:647 → 734
    I-set; Immunoglobulin I-set domain
    pfam13855
    Location:338 → 389
    LRR_8; Leucine rich repeat
    pfam13927
    Location:448 → 535
    Ig_3; Immunoglobulin domain
    cd00096
    Location:655 → 658
    Ig; Ig strand A' [structural motif]
    cd05763
    Location:554 → 644
    IgI_LRIG1-like; Immunoglobulin (Ig)-like ectodomain of the LRIG1 (Leucine-rich Repeats And Immunoglobulin-like Domains Protein 1) and similar proteins; member of the I-set of IgSF domains
    cd21340
    Location:171 → 349
    PPP1R42; protein phosphatase 1 regulatory subunit 42
    cl39015
    Location:16 → 204
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

  3. XM_006501544.4 → XP_006501607.1  leucine-rich repeats and immunoglobulin-like domains protein 2 isoform X2

    Conserved Domains (4) summary
    cd05763
    Location:200 → 274
    Ig_1; Subgroup of the immunoglobulin (Ig) superfamily
    smart00082
    Location:26 → 74
    LRRCT; Leucine rich repeat C-terminal domain
    pfam07679
    Location:277 → 364
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:83 → 179
    Ig; Immunoglobulin domain

  4. XM_030252634.2 → XP_030108494.1  leucine-rich repeats and immunoglobulin-like domains protein 2 isoform X4

    Conserved Domains (3) summary
    cd05763
    Location:91 → 165
    Ig_1; Subgroup of the immunoglobulin (Ig) superfamily
    pfam07679
    Location:168 → 255
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:5 → 70
    Ig; Immunoglobulin domain

RNA

  1. XR_004941331.1 RNA Sequence

  2. XR_004941330.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q52KR2.1 GenPept UniProtKB/Swiss-Prot:Q52KR2

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