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Serinc3 serine incorporator 3 [ Mus musculus (house mouse) ]

Gene ID: 26943, updated on 11-Apr-2024

Summary

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Official Symbol
Serinc3provided by MGI
Official Full Name
serine incorporator 3provided by MGI
Primary source
MGI:MGI:1349457
See related
Ensembl:ENSMUSG00000017707 AllianceGenome:MGI:1349457
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tde1; AIGP1; TMS-1; DIFF33
Summary
Acts upstream of or within positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway. Located in Golgi apparatus and plasma membrane. Is expressed in several structures, including adrenal medulla; craniocervical region bone; ganglia; liver lobe; and thymus primordium. Orthologous to human SERINC3 (serine incorporator 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in genital fat pad adult (RPKM 233.6), ovary adult (RPKM 192.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 H3; 2 84.38 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (163466577..163487767, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (163623273..163645149, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2652 Neighboring gene STARR-seq mESC enhancer starr_06312 Neighboring gene Crx opposite strand transcript 1 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E9538 Neighboring gene STARR-positive B cell enhancer ABC_E2057 Neighboring gene tocopherol (alpha) transfer protein-like Neighboring gene STARR-positive B cell enhancer ABC_E10159 Neighboring gene RIKEN cDNA 0610039K10 gene Neighboring gene STARR-positive B cell enhancer ABC_E9208 Neighboring gene STARR-positive B cell enhancer ABC_E819 Neighboring gene STARR-seq mESC enhancer starr_06314 Neighboring gene STARR-positive B cell enhancer ABC_E2058 Neighboring gene protein kinase inhibitor, gamma Neighboring gene predicted gene 16316 Neighboring gene adenosine deaminase intronic regulatory elements Neighboring gene adenosine deaminase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Sequence analysis of a novel cDNA which is overexpressed in testicular tumors from polyomavirus large T-antigen transgenic mice. Lebel M, et al. DNA Seq, 1994. PMID 7894057
  2. The human TDE gene homologue: localization to 20q13.1-13.3 and variable expression in human tumor cell lines and tissue. Bossolasco M, et al. Mol Carcinog, 1999 Nov. PMID 10559794
  3. Human TDE1, a TDE1/TMS family member, inhibits apoptosis in vitro and stimulates in vivo tumorigenesis. Bossolasco M, et al. Oncogene, 2006 Aug 3. PMID 16547497
  4. Identification of an axotomy-induced glycosylated protein, AIGP1, possibly involved in cell death triggered by endoplasmic reticulum-Golgi stress. Aoki S, et al. J Neurosci, 2002 Dec 15. PMID 12486168, Free PMC Article
  5. SERINC5 Potently Restricts Retrovirus Infection In Vivo. Timilsina U, et al. mBio, 2020 Jul 14. PMID 32665269, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TDE1 inhibits apoptosis and stimulates tumorigenesis
    Title: Human TDE1, a TDE1/TMS family member, inhibits apoptosis in vitro and stimulates in vivo tumorigenesis.
  2. results suggest that AIGP1 gene activation and protein accumulation in the Golgi complex in response to axotomy-induced ER-Golgi stress may contribute to signaling during programmed cell death in damaged neurons [AIGP1]
    Title: Identification of an axotomy-induced glycosylated protein, AIGP1, possibly involved in cell death triggered by endoplasmic reticulum-Golgi stress.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in defense response to virus ISO
Inferred from Sequence Orthology
more info
  
involved_in detection of virus ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
involved_in innate immune response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
serine incorporator 3
Names
AIGP-1
axotomy-induced glyco/Golgi protein 1
axotomy-induced glycoprotein 1
membrane protein TMS-1
tumor differentially expressed 1
tumor differentially expressed protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001412441.1 → NP_001399370.1  serine incorporator 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL591488, AL591490

  2. NM_001412442.1 → NP_001399371.1  serine incorporator 3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL591488, AL591490

  3. NM_001412443.1 → NP_001399372.1  serine incorporator 3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL591488, AL591490

  4. NM_001412444.1 → NP_001399373.1  serine incorporator 3 isoform 5 precursor

    Status: VALIDATED

    Source sequence(s)
    AL591488, AL591490

  5. NM_001412445.1 → NP_001399374.1  serine incorporator 3 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL591488, AL591490

  6. NM_001412447.1 → NP_001399376.1  serine incorporator 3 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL591488, AL591490

  7. NM_001412448.1 → NP_001399377.1  serine incorporator 3 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL591488, AL591490

  8. NM_001412449.1 → NP_001399378.1  serine incorporator 3 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL591488, AL591490

  9. NM_001412450.1 → NP_001399379.1  serine incorporator 3 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL591488, AL591490

  10. NM_001412451.1 → NP_001399380.1  serine incorporator 3 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL591488, AL591490

  11. NM_001412452.1 → NP_001399381.1  serine incorporator 3 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL591488, AL591490

  12. NM_001412453.1 → NP_001399382.1  serine incorporator 3 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL591488, AL591490

  13. NM_001412454.1 → NP_001399383.1  serine incorporator 3 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AL591488, AL591490

  14. NM_001412455.1 → NP_001399384.1  serine incorporator 3 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AL591488, AL591490

  15. NM_001412456.1 → NP_001399385.1  serine incorporator 3 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AL591488, AL591490

  16. NM_012032.5 → NP_036162.3  serine incorporator 3 isoform 1

    See identical proteins and their annotated locations for NP_036162.3

    Status: VALIDATED

    Source sequence(s)
    AL591488, AL591490
    Consensus CDS
    CCDS17013.1
    UniProtKB/Swiss-Prot
    Q3U7C6, Q62310, Q8BSP9, Q8CFD3, Q91VN9, Q9QZI9
    UniProtKB/TrEMBL
    Q3TWZ3
    Related
    ENSMUSP00000017851.4, ENSMUST00000017851.4
    Conserved Domains (1) summary
    pfam03348
    Location:16 → 470
    Serinc; Serine incorporator (Serinc)

RNA

  1. NR_178197.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL591488, AL591490

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    163466577..163487767 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006499616.4 → XP_006499679.1  serine incorporator 3 isoform X2

    UniProtKB/TrEMBL
    Q3TWZ3
    Conserved Domains (1) summary
    pfam03348
    Location:1 → 415
    Serinc; Serine incorporator (Serinc)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QZI9.2 GenPept UniProtKB/Swiss-Prot:Q9QZI9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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