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Ss18l1 SS18, nBAF chromatin remodeling complex subunit like 1 [ Mus musculus (house mouse) ]

Gene ID: 269397, updated on 11-Apr-2024

Summary

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Official Symbol
Ss18l1provided by MGI
Official Full Name
SS18, nBAF chromatin remodeling complex subunit like 1provided by MGI
Primary source
MGI:MGI:2444061
See related
Ensembl:ENSMUSG00000039086 AllianceGenome:MGI:2444061
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CREST; A230053O16Rik
Summary
Predicted to enable DNA binding activity and DNA-binding transcription factor activity. Acts upstream of or within dendrite development and positive regulation of dendrite morphogenesis. Located in condensed chromosome, centromeric region. Part of nBAF complex. Is expressed in brain; primary oocyte; spermatocyte; and testis. Orthologous to human SS18L1 (SS18L1 subunit of BAF chromatin remodeling complex). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in genital fat pad adult (RPKM 17.2), whole brain E14.5 (RPKM 15.9) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 H4; 2 102.56 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (179684276..179711994)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (180042483..180070201)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene LSM family member 14B Neighboring gene proteasome subunit alpha 7 Neighboring gene STARR-positive B cell enhancer ABC_E7897 Neighboring gene mitochondrial ribosome associated GTPase 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:179830439-179830640 Neighboring gene histamine receptor H3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Loss of CREST leads to neuroinflammatory responses and ALS-like motor defects in mice. Cheng C, et al. Transl Neurodegener, 2019. PMID 30976389, Free PMC Article
  2. CREST in the Nucleus Accumbens Core Regulates Cocaine Conditioned Place Preference, Cocaine-Seeking Behavior, and Synaptic Plasticity. Alaghband Y, et al. J Neurosci, 2018 Oct 31. PMID 30228227, Free PMC Article
  3. Targeted disruption of the synovial sarcoma-associated SS18 gene causes early embryonic lethality and affects PPARBP expression. de Bruijn DR, et al. Hum Mol Genet, 2006 Oct 1. PMID 16926188
  4. Hypoxic adaptation engages the CBP/CREST-induced coactivator complex of Creb-HIF-1α in transactivating murine neuroblastic glucose transporter. Thamotharan S, et al. Am J Physiol Endocrinol Metab, 2013 Mar 15. PMID 23321477, Free PMC Article
  5. A maternal store of macroH2A is removed from pronuclei prior to onset of somatic macroH2A expression in preimplantation embryos. Chang CC, et al. Dev Biol, 2005 Feb 15. PMID 15680357

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CREST in the nucleus accumbens core is required for cocaine-induced conditioned place preference, synaptic plasticity and cocaine-seeking behavior.
    Title: CREST in the Nucleus Accumbens Core Regulates Cocaine Conditioned Place Preference, Cocaine-Seeking Behavior, and Synaptic Plasticity.
  2. Data suggest that co-activation of CREST and CBP (CREB-binding protein) enhances signaling between p-Creb/AP-1 and p-HIF-1/HRE resulting in up-regulation of Glut3 (glucose transporter type 3); here, stimulus was cell hypoxia.
    Title: Hypoxic adaptation engages the CBP/CREST-induced coactivator complex of Creb-HIF-1α in transactivating murine neuroblastic glucose transporter.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within dendrite development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of dendrite morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in regulation of dendrite development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, centromeric region ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in condensed chromosome, centromeric region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
 PubMed 
part_of nBAF complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
calcium-responsive transactivator
Names
SS18-like protein 1
synovial sarcoma translocation gene on chromosome 18-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178750.5 → NP_848865.4  calcium-responsive transactivator

    See identical proteins and their annotated locations for NP_848865.4

    Status: VALIDATED

    Source sequence(s)
    AK133944, BC054730, BY274705
    Consensus CDS
    CCDS17167.1
    UniProtKB/Swiss-Prot
    Q6A014, Q7TQF3, Q8BW22, Q8BYQ7
    Related
    ENSMUSP00000041288.9, ENSMUST00000041126.9
    Conserved Domains (1) summary
    pfam05030
    Location:14 → 73
    SSXT; SSXT protein (N-terminal region)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    179684276..179711994
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006500632.2 → XP_006500695.1  calcium-responsive transactivator isoform X2

  2. XM_006500631.5 → XP_006500694.1  calcium-responsive transactivator isoform X1

    Conserved Domains (1) summary
    pfam05030
    Location:1 → 50
    SSXT; SSXT protein (N-terminal region)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BW22.1 GenPept UniProtKB/Swiss-Prot:Q8BW22

Gene LinkOut

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